Cellular Localization of the Endothelin System in the Lung View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1999

AUTHORS

Nicholas W. Morrell , Carlos Orte , John Wharton , Julia M. Polak

ABSTRACT

Although the endothelium is considered the main site of production of the endothelins, many other cell types in the lung are capable of endothelin synthesis, implying numerous potential roles for endothelins in lung biology. The endothelins were characterised originally as powerful vasoconstrictors, however, it is becoming clear that their effects may vary depending on the predominant receptor subtype present and the initial tone of the vascular bed. In addition, endothelins may be mitogenic and chemotactic for lung fibroblasts and smooth muscle cells derived from the airways or pulmonary circulation. Furthermore, their presence during development raises the possibility that these peptides may contribute to growth of the normal lung in addition to pathological remodelling of the airways and lung vasculature. More... »

PAGES

49-62

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-0348-8821-9_3

DOI

http://dx.doi.org/10.1007/978-3-0348-8821-9_3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043569305


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