The role of IL-6 and related cytokines in myocardial remodeling and inflammation – implication for cardiac hypertrophy and heart failure View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2003

AUTHORS

Antoine Bril , Giora Z. Feuerstein

ABSTRACT

Cardiac remodeling is a complex dynamic process occurring in reaction to an insult to the myocardium and contributing to the development of congestive heart failure (CHF). Left ventricular remodeling occurs either in response to a loss of cardiac cells as observed after myocardial infarction (MI), or in response to a hemodynamic overload as is the case in patients with chronic hypertension. The remodeling of cardiac tissue is characterized by the presence of hypertrophy, apoptosis and extracellular matrix re-organization and is associated with an inflammatory response [1-3]. Among the different factors involved in the development of cardiac remodeling, recent evidence has suggested a role for various pleiotropic cytokines, including interleukin-6 (IL-6), cardiotrophin-1 (CT-1) and others. Through the stimulation of tyrosine-kinase specific receptors, these cytokines lead to the activation of fetal gene regulatory programs, cardiac cell growth and survival. More... »

PAGES

111-127

Book

TITLE

Inflammation and Cardiac Diseases

ISBN

978-3-0348-9419-7
978-3-0348-8047-3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-0348-8047-3_7

DOI

http://dx.doi.org/10.1007/978-3-0348-8047-3_7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034446077


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