Potassium channel openers: Airway pharmacology and clinical possibilities in asthma View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1991

AUTHORS

John A. Salmon , Lawrence G. Garland , Brian D. Hoyle , J. William Costerton , Nikolaus Seiler , David Raeburn , Jan-Anders Karlsson , A. Polak , P. G. Hartman , Michel Rohmer , Philippe Bisseret , Bertrand Sutter , Alfred Burger

ABSTRACT

Asthma is a common disease worldwide, generally affecting 5–10% of the population, and its incidence is, unfortunately, still on the increase. This is despite intensive research into its pathophysiology and the development of several new therapeutic agents. The clinical symptoms of asthma are very obvious and distressing yet we still have only a rudimentary picture of the pathophysiological mechanisms involved. Airway inflammation and hyperreactivity are characteristic features and, since they seem to correlate with the severity of the disease, asthma is now widely regarded as an inflammatory disease [1–3]. Consequently, research into the physiology and pharmacology of airway smooth muscle and the role of bronchodilator drugs has attracted comparatively less interest in recent years. However, the importance of controlling airway smooth muscle contractility to improve airflow and so provide immediate, symptomatic relief for the asthmatic patient is still vital and indeed the bronchodilators remain the first line therapy [3]. More... »

PAGES

161-180

References to SciGraph publications

  • 2005-06-21. Peptide toxins and potassium channels in REVIEWS OF PHYSIOLOGY, BIOCHEMISTRY AND PHARMACOLOGY, VOLUME 94
  • 1989-09. Regulation of Ca2+ -dependent K+ -channel activity in tracheal myocytes by phosphorylation in NATURE
  • 1989. Ion Channels in Airway Smooth Muscle in AIRWAY SMOOTH MUSCLE IN HEALTH AND DISEASE
  • Book

    TITLE

    Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques

    ISBN

    978-3-7643-2626-5
    978-3-0348-7139-6

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-0348-7139-6_4

    DOI

    http://dx.doi.org/10.1007/978-3-0348-7139-6_4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008195724


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