Intraductal Tumors of the Biliary Tract: Precursor Lesions and Variants View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2021-05-29

AUTHORS

Yasuni Nakanuma , Katsuhiko Uesaka , Masayuki Ohtsuka , Koushiro Ohtsubo , Dai Inoue , Kazuto Kozaka

ABSTRACT

Among the several known intraductal neoplasms of the bile duct, intraductal papillary neoplasm of the bile duct (IPNB) was recently classified as a distinct pathologic entity, which shows grossly exophytic growth in a dilated bile duct lumen, with histologically villous, papillary, or tubular neoplastic epithelia covering fine fibrovascular stalks. While IPNBs are usually a preinvasive lesion, approximately half show stromal invasion (IPNB associated with invasive carcinoma) at the time of surgical resection. IPNBs are pathologically classified into the intestinal, gastric, pancreatobiliary, and oncocytic subtypes. IPNBs were initially graded into low-grade and high-grade dysplasia: recent subclassification of IPNB grades into types 1 (low-grade and high-grade dysplasia with regular architectures) and 2 (high-grade dysplasia with irregular architectures) shows different clinical courses and genetic alterations. Cross-sectional imaging is valuable for delineation of bile duct dilatation and intraductal masses. Cholangiography and cholangioscopy are used to detect mucin hyperproduction, observe the tumor and biliary mucosa, and obtain tissue and cytology samples. Treatment should be considered for all IPNB patients, with surgical resection being the major and most definitive treatment. More... »

PAGES

27-67

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-030-70936-5_3

DOI

http://dx.doi.org/10.1007/978-3-030-70936-5_3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1138438058


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