Intraductal Tumors of the Biliary Tract: Precursor Lesions and Variants View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2021-05-29

AUTHORS

Yasuni Nakanuma , Katsuhiko Uesaka , Masayuki Ohtsuka , Koushiro Ohtsubo , Dai Inoue , Kazuto Kozaka

ABSTRACT

Among the several known intraductal neoplasms of the bile duct, intraductal papillary neoplasm of the bile duct (IPNB) was recently classified as a distinct pathologic entity, which shows grossly exophytic growth in a dilated bile duct lumen, with histologically villous, papillary, or tubular neoplastic epithelia covering fine fibrovascular stalks. While IPNBs are usually a preinvasive lesion, approximately half show stromal invasion (IPNB associated with invasive carcinoma) at the time of surgical resection. IPNBs are pathologically classified into the intestinal, gastric, pancreatobiliary, and oncocytic subtypes. IPNBs were initially graded into low-grade and high-grade dysplasia: recent subclassification of IPNB grades into types 1 (low-grade and high-grade dysplasia with regular architectures) and 2 (high-grade dysplasia with irregular architectures) shows different clinical courses and genetic alterations. Cross-sectional imaging is valuable for delineation of bile duct dilatation and intraductal masses. Cholangiography and cholangioscopy are used to detect mucin hyperproduction, observe the tumor and biliary mucosa, and obtain tissue and cytology samples. Treatment should be considered for all IPNB patients, with surgical resection being the major and most definitive treatment. More... »

PAGES

27-67

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-030-70936-5_3

DOI

http://dx.doi.org/10.1007/978-3-030-70936-5_3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1138438058


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Diagnostic Pathology, Fukui Prefecture Saiseikai Hospital, Fukui, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Diagnostic Pathology, Shizuoka Cancer Center, Shizuoka, Japan", 
            "Department of Diagnostic Pathology, Fukui Prefecture Saiseikai Hospital, Fukui, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakanuma", 
        "givenName": "Yasuni", 
        "id": "sg:person.01135741606.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135741606.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hepatobiliary Pancreaetic Surgery, Shizuoka Cancer Center, Shizuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415797.9", 
          "name": [
            "Department of Hepatobiliary Pancreaetic Surgery, Shizuoka Cancer Center, Shizuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uesaka", 
        "givenName": "Katsuhiko", 
        "id": "sg:person.0764275210.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764275210.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hepatobiliary Pancreatic Surgery, Chiba University Hospital, Chiba, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411321.4", 
          "name": [
            "Department of Hepatobiliary Pancreatic Surgery, Chiba University Hospital, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohtsuka", 
        "givenName": "Masayuki", 
        "id": "sg:person.0653527253.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653527253.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Medical Oncology, Cancer Institute, Kanazawa University Hospital, Kanazawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412002.5", 
          "name": [
            "Division of Medical Oncology, Cancer Institute, Kanazawa University Hospital, Kanazawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohtsubo", 
        "givenName": "Koushiro", 
        "id": "sg:person.010643141224.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010643141224.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Kanazawa University Hospital, Kanazawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412002.5", 
          "name": [
            "Department of Radiology, Kanazawa University Hospital, Kanazawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Inoue", 
        "givenName": "Dai", 
        "id": "sg:person.01003417203.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003417203.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Kanazawa University Hospital, Kanazawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412002.5", 
          "name": [
            "Department of Radiology, Kanazawa University Hospital, Kanazawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kozaka", 
        "givenName": "Kazuto", 
        "id": "sg:person.0675354662.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675354662.31"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2021-05-29", 
    "datePublishedReg": "2021-05-29", 
    "description": "Among the several known intraductal neoplasms of the bile duct, intraductal papillary neoplasm of the bile duct (IPNB) was recently classified as a distinct pathologic entity, which shows grossly exophytic growth in a dilated bile duct lumen, with histologically villous, papillary, or tubular neoplastic epithelia covering fine fibrovascular stalks. While IPNBs are usually a preinvasive lesion, approximately half show stromal invasion (IPNB associated with invasive carcinoma) at the time of surgical resection. IPNBs are pathologically classified into the intestinal, gastric, pancreatobiliary, and oncocytic subtypes. IPNBs were initially graded into low-grade and high-grade dysplasia: recent subclassification of IPNB grades into types 1 (low-grade and high-grade dysplasia with regular architectures) and 2 (high-grade dysplasia with irregular architectures) shows different clinical courses and genetic alterations. Cross-sectional imaging is valuable for delineation of bile duct dilatation and intraductal masses. Cholangiography and cholangioscopy are used to detect mucin hyperproduction, observe the tumor and biliary mucosa, and obtain tissue and cytology samples. Treatment should be considered for all IPNB patients, with surgical resection being the major and most definitive treatment.", 
    "editor": [
      {
        "familyName": "Tabibian", 
        "givenName": "James H.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-3-030-70936-5_3", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-3-030-70935-8", 
        "978-3-030-70936-5"
      ], 
      "name": "Diagnosis and Management of Cholangiocarcinoma", 
      "type": "Book"
    }, 
    "keywords": [
      "surgical resection", 
      "bile duct", 
      "fine fibrovascular stalks", 
      "intraductal papillary neoplasm", 
      "bile duct lumen", 
      "bile duct dilatation", 
      "high-grade dysplasia", 
      "different clinical courses", 
      "distinct pathologic entity", 
      "cross-sectional imaging", 
      "oncocytic subtype", 
      "recent subclassification", 
      "mucin hyperproduction", 
      "biliary mucosa", 
      "IPNB patients", 
      "intraductal mass", 
      "clinical course", 
      "duct dilatation", 
      "definitive treatment", 
      "papillary neoplasm", 
      "fibrovascular stalks", 
      "stromal invasion", 
      "biliary tract", 
      "exophytic growth", 
      "intraductal tumors", 
      "neoplastic epithelium", 
      "preinvasive lesions", 
      "pathologic entity", 
      "precursor lesions", 
      "intraductal neoplasms", 
      "cytology samples", 
      "IPNB", 
      "type 1", 
      "duct lumen", 
      "genetic alterations", 
      "resection", 
      "neoplasms", 
      "lesions", 
      "tumors", 
      "treatment", 
      "duct", 
      "cholangiography", 
      "patients", 
      "cholangioscopy", 
      "dysplasia", 
      "mucosa", 
      "dilatation", 
      "subtypes", 
      "subclassification", 
      "tract", 
      "epithelium", 
      "hyperproduction", 
      "lumen", 
      "invasion", 
      "tissue", 
      "alterations", 
      "imaging", 
      "grade", 
      "course", 
      "variants", 
      "entities", 
      "delineation", 
      "mass", 
      "samples", 
      "time", 
      "stalk", 
      "growth"
    ], 
    "name": "Intraductal Tumors of the Biliary Tract: Precursor Lesions and Variants", 
    "pagination": "27-67", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1138438058"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-3-030-70936-5_3"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-3-030-70936-5_3", 
      "https://app.dimensions.ai/details/publication/pub.1138438058"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-09-02T16:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/chapter/chapter_58.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-3-030-70936-5_3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-030-70936-5_3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-030-70936-5_3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-030-70936-5_3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-030-70936-5_3'


 

This table displays all metadata directly associated to this object as RDF triples.

173 TRIPLES      22 PREDICATES      91 URIs      84 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-3-030-70936-5_3 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N4f0303cb01de48fb8be8032ab8b86fbc
4 schema:datePublished 2021-05-29
5 schema:datePublishedReg 2021-05-29
6 schema:description Among the several known intraductal neoplasms of the bile duct, intraductal papillary neoplasm of the bile duct (IPNB) was recently classified as a distinct pathologic entity, which shows grossly exophytic growth in a dilated bile duct lumen, with histologically villous, papillary, or tubular neoplastic epithelia covering fine fibrovascular stalks. While IPNBs are usually a preinvasive lesion, approximately half show stromal invasion (IPNB associated with invasive carcinoma) at the time of surgical resection. IPNBs are pathologically classified into the intestinal, gastric, pancreatobiliary, and oncocytic subtypes. IPNBs were initially graded into low-grade and high-grade dysplasia: recent subclassification of IPNB grades into types 1 (low-grade and high-grade dysplasia with regular architectures) and 2 (high-grade dysplasia with irregular architectures) shows different clinical courses and genetic alterations. Cross-sectional imaging is valuable for delineation of bile duct dilatation and intraductal masses. Cholangiography and cholangioscopy are used to detect mucin hyperproduction, observe the tumor and biliary mucosa, and obtain tissue and cytology samples. Treatment should be considered for all IPNB patients, with surgical resection being the major and most definitive treatment.
7 schema:editor N076d34f7d5164d6d98e8839d121f56cf
8 schema:genre chapter
9 schema:isAccessibleForFree false
10 schema:isPartOf Nb07b3dc689f843a1bbf39e1bb7032320
11 schema:keywords IPNB
12 IPNB patients
13 alterations
14 bile duct
15 bile duct dilatation
16 bile duct lumen
17 biliary mucosa
18 biliary tract
19 cholangiography
20 cholangioscopy
21 clinical course
22 course
23 cross-sectional imaging
24 cytology samples
25 definitive treatment
26 delineation
27 different clinical courses
28 dilatation
29 distinct pathologic entity
30 duct
31 duct dilatation
32 duct lumen
33 dysplasia
34 entities
35 epithelium
36 exophytic growth
37 fibrovascular stalks
38 fine fibrovascular stalks
39 genetic alterations
40 grade
41 growth
42 high-grade dysplasia
43 hyperproduction
44 imaging
45 intraductal mass
46 intraductal neoplasms
47 intraductal papillary neoplasm
48 intraductal tumors
49 invasion
50 lesions
51 lumen
52 mass
53 mucin hyperproduction
54 mucosa
55 neoplasms
56 neoplastic epithelium
57 oncocytic subtype
58 papillary neoplasm
59 pathologic entity
60 patients
61 precursor lesions
62 preinvasive lesions
63 recent subclassification
64 resection
65 samples
66 stalk
67 stromal invasion
68 subclassification
69 subtypes
70 surgical resection
71 time
72 tissue
73 tract
74 treatment
75 tumors
76 type 1
77 variants
78 schema:name Intraductal Tumors of the Biliary Tract: Precursor Lesions and Variants
79 schema:pagination 27-67
80 schema:productId N4945d2d227534e60a90392cc28d22a59
81 N90e1c5045d3c49e794b63081ac288ce3
82 schema:publisher N179a701fe71840ddbe2af0869d085464
83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1138438058
84 https://doi.org/10.1007/978-3-030-70936-5_3
85 schema:sdDatePublished 2022-09-02T16:18
86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
87 schema:sdPublisher Nbab3572372c145e194d95e94848076a3
88 schema:url https://doi.org/10.1007/978-3-030-70936-5_3
89 sgo:license sg:explorer/license/
90 sgo:sdDataset chapters
91 rdf:type schema:Chapter
92 N076d34f7d5164d6d98e8839d121f56cf rdf:first Na63de56517a74f78aba69b3276bd2331
93 rdf:rest rdf:nil
94 N105732743f4b4bd29af34079939a0185 rdf:first sg:person.0764275210.22
95 rdf:rest N4c0793dfa81143d3821e663d273fd384
96 N179a701fe71840ddbe2af0869d085464 schema:name Springer Nature
97 rdf:type schema:Organisation
98 N4945d2d227534e60a90392cc28d22a59 schema:name dimensions_id
99 schema:value pub.1138438058
100 rdf:type schema:PropertyValue
101 N4c0793dfa81143d3821e663d273fd384 rdf:first sg:person.0653527253.30
102 rdf:rest N75dd9efdae8343f8905d2b5ad85ea686
103 N4f0303cb01de48fb8be8032ab8b86fbc rdf:first sg:person.01135741606.70
104 rdf:rest N105732743f4b4bd29af34079939a0185
105 N75dd9efdae8343f8905d2b5ad85ea686 rdf:first sg:person.010643141224.80
106 rdf:rest Nf94b7abc3aa24f1091ccf2a6e25cf32b
107 N7a7c56c14d114bbea2b07a124d84eded rdf:first sg:person.0675354662.31
108 rdf:rest rdf:nil
109 N90e1c5045d3c49e794b63081ac288ce3 schema:name doi
110 schema:value 10.1007/978-3-030-70936-5_3
111 rdf:type schema:PropertyValue
112 Na63de56517a74f78aba69b3276bd2331 schema:familyName Tabibian
113 schema:givenName James H.
114 rdf:type schema:Person
115 Nb07b3dc689f843a1bbf39e1bb7032320 schema:isbn 978-3-030-70935-8
116 978-3-030-70936-5
117 schema:name Diagnosis and Management of Cholangiocarcinoma
118 rdf:type schema:Book
119 Nbab3572372c145e194d95e94848076a3 schema:name Springer Nature - SN SciGraph project
120 rdf:type schema:Organization
121 Nf94b7abc3aa24f1091ccf2a6e25cf32b rdf:first sg:person.01003417203.48
122 rdf:rest N7a7c56c14d114bbea2b07a124d84eded
123 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
124 schema:name Medical and Health Sciences
125 rdf:type schema:DefinedTerm
126 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
127 schema:name Oncology and Carcinogenesis
128 rdf:type schema:DefinedTerm
129 sg:person.01003417203.48 schema:affiliation grid-institutes:grid.412002.5
130 schema:familyName Inoue
131 schema:givenName Dai
132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003417203.48
133 rdf:type schema:Person
134 sg:person.010643141224.80 schema:affiliation grid-institutes:grid.412002.5
135 schema:familyName Ohtsubo
136 schema:givenName Koushiro
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010643141224.80
138 rdf:type schema:Person
139 sg:person.01135741606.70 schema:affiliation grid-institutes:None
140 schema:familyName Nakanuma
141 schema:givenName Yasuni
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135741606.70
143 rdf:type schema:Person
144 sg:person.0653527253.30 schema:affiliation grid-institutes:grid.411321.4
145 schema:familyName Ohtsuka
146 schema:givenName Masayuki
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653527253.30
148 rdf:type schema:Person
149 sg:person.0675354662.31 schema:affiliation grid-institutes:grid.412002.5
150 schema:familyName Kozaka
151 schema:givenName Kazuto
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675354662.31
153 rdf:type schema:Person
154 sg:person.0764275210.22 schema:affiliation grid-institutes:grid.415797.9
155 schema:familyName Uesaka
156 schema:givenName Katsuhiko
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764275210.22
158 rdf:type schema:Person
159 grid-institutes:None schema:alternateName Department of Diagnostic Pathology, Fukui Prefecture Saiseikai Hospital, Fukui, Japan
160 schema:name Department of Diagnostic Pathology, Fukui Prefecture Saiseikai Hospital, Fukui, Japan
161 Department of Diagnostic Pathology, Shizuoka Cancer Center, Shizuoka, Japan
162 rdf:type schema:Organization
163 grid-institutes:grid.411321.4 schema:alternateName Department of Hepatobiliary Pancreatic Surgery, Chiba University Hospital, Chiba, Japan
164 schema:name Department of Hepatobiliary Pancreatic Surgery, Chiba University Hospital, Chiba, Japan
165 rdf:type schema:Organization
166 grid-institutes:grid.412002.5 schema:alternateName Department of Radiology, Kanazawa University Hospital, Kanazawa, Japan
167 Division of Medical Oncology, Cancer Institute, Kanazawa University Hospital, Kanazawa, Japan
168 schema:name Department of Radiology, Kanazawa University Hospital, Kanazawa, Japan
169 Division of Medical Oncology, Cancer Institute, Kanazawa University Hospital, Kanazawa, Japan
170 rdf:type schema:Organization
171 grid-institutes:grid.415797.9 schema:alternateName Department of Hepatobiliary Pancreaetic Surgery, Shizuoka Cancer Center, Shizuoka, Japan
172 schema:name Department of Hepatobiliary Pancreaetic Surgery, Shizuoka Cancer Center, Shizuoka, Japan
173 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...