The Role of CA 19-9 in Pancreatic Adenocarcinoma View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2021-02-05

AUTHORS

Clémence Guyard , Stylianos Tzedakis , Elisabeth Hain , Justine Guyard , Vincent Mallet , Sébastien Gaujoux

ABSTRACT

Carbohydrate antigen 19.9 (CA 19-9) is a ganglioside synthesized by epithelial cells of different organs and is therefore not organ-specific. It is most commonly found elevated in malignant disease but benign causes like biliary obstruction may increase CA 19-9 values. There are rare cases however, like in patients with a negative Lewis system, that CA19-9 is never elevated. Unsuitable for screening in pancreatic adenocarcinoma, CA19-9 may have a prognostic value in preoperative assessment, high values (>1000 U/mL) often being associated with micro-metastatic disease. Moreover, it is useful in evaluating response to treatment with decreasing values being an indicator of increased survival. Finally, postoperative surveillance can facilitate early detection of recurrence and in cases of unresectable pancreatic adenocarcinoma CA 19-9 appears to be a good indicator of overall survival. More... »

PAGES

455-466

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-030-53786-9_30

DOI

http://dx.doi.org/10.1007/978-3-030-53786-9_30

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1135138456


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