2020-09-30
AUTHORSBieneke Janssen , Danielle J. Vugts , Albert D. Windhorst
ABSTRACTOver the recent years, interest in the purinergic signaling system has sparked in the field of positron emission tomography (PET). Purinergic receptors play key roles in physiological and pathological processes, although the exact role in these processes is not always fully understood. PET provides an excellent imaging technique to study (patho)physiological processes in the living brain, and therefore radiopharmaceuticals (or tracers) targeting different purinergic receptors have been developed recently. This chapter will discuss the state of the art of PET tracer development for the P2 family of purinergic receptors, which is especially of interest for visualization of neuroinflammation, more specifically microglial activation. More... »
PAGES879-889
PET and SPECT of Neurobiological Systems
ISBN
978-3-030-53175-1
978-3-030-53176-8
http://scigraph.springernature.com/pub.10.1007/978-3-030-53176-8_24
DOIhttp://dx.doi.org/10.1007/978-3-030-53176-8_24
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1131288948
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Neurosciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA",
"id": "http://www.grid.ac/institutes/grid.25879.31",
"name": [
"Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"
],
"type": "Organization"
},
"familyName": "Janssen",
"givenName": "Bieneke",
"id": "sg:person.0714506234.04",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714506234.04"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands",
"id": "http://www.grid.ac/institutes/grid.12380.38",
"name": [
"Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Vugts",
"givenName": "Danielle J.",
"id": "sg:person.0665425270.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665425270.49"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands",
"id": "http://www.grid.ac/institutes/grid.12380.38",
"name": [
"Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Windhorst",
"givenName": "Albert D.",
"id": "sg:person.0713207641.74",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713207641.74"
],
"type": "Person"
}
],
"datePublished": "2020-09-30",
"datePublishedReg": "2020-09-30",
"description": "Over the recent years, interest in the purinergic signaling system has sparked in the field of positron emission tomography (PET). Purinergic receptors play key roles in physiological and pathological processes, although the exact role in these processes is not always fully understood. PET provides an excellent imaging technique to study (patho)physiological processes in the living brain, and therefore radiopharmaceuticals (or tracers) targeting different purinergic receptors have been developed recently. This chapter will discuss the state of the art of PET tracer development for the P2 family of purinergic receptors, which is especially of interest for visualization of neuroinflammation, more specifically microglial activation.",
"editor": [
{
"familyName": "Dierckx",
"givenName": "Rudi A.J.O.",
"type": "Person"
},
{
"familyName": "Otte",
"givenName": "Andreas",
"type": "Person"
},
{
"familyName": "de Vries",
"givenName": "Erik F.J.",
"type": "Person"
},
{
"familyName": "van Waarde",
"givenName": "Aren",
"type": "Person"
},
{
"familyName": "Lammertsma",
"givenName": "Adriaan A.",
"type": "Person"
}
],
"genre": "chapter",
"id": "sg:pub.10.1007/978-3-030-53176-8_24",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": {
"isbn": [
"978-3-030-53175-1",
"978-3-030-53176-8"
],
"name": "PET and SPECT of Neurobiological Systems",
"type": "Book"
},
"keywords": [
"positron emission tomography",
"purinergic receptors",
"different purinergic receptors",
"excellent imaging technique",
"visualization of neuroinflammation",
"microglial activation",
"purinergic signaling system",
"emission tomography",
"living brain",
"PET imaging",
"pathological processes",
"receptors",
"exact role",
"PET tracer development",
"imaging techniques",
"tracer development",
"P2 family",
"neuroinflammation",
"brain",
"key role",
"tomography",
"signaling system",
"role",
"radiopharmaceuticals",
"activation",
"imaging",
"years",
"recent years",
"family",
"development",
"visualization",
"interest",
"technique",
"process",
"chapter",
"state",
"system",
"art",
"field"
],
"name": "PET Imaging of Purinergic Receptors",
"pagination": "879-889",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1131288948"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/978-3-030-53176-8_24"
]
}
],
"publisher": {
"name": "Springer Nature",
"type": "Organisation"
},
"sameAs": [
"https://doi.org/10.1007/978-3-030-53176-8_24",
"https://app.dimensions.ai/details/publication/pub.1131288948"
],
"sdDataset": "chapters",
"sdDatePublished": "2022-05-20T07:41",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/chapter/chapter_111.jsonl",
"type": "Chapter",
"url": "https://doi.org/10.1007/978-3-030-53176-8_24"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-030-53176-8_24'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-030-53176-8_24'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-030-53176-8_24'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-030-53176-8_24'
This table displays all metadata directly associated to this object as RDF triples.
136 TRIPLES
23 PREDICATES
63 URIs
56 LITERALS
7 BLANK NODES