Fertility Protection in Childhood, Adolescents and Young Adulthood Cancer Patients View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2020-11-06

AUTHORS

Sebastian Findeklee , Michael von Wolff

ABSTRACT

While the prognosis of cancer diseases has improved during the last decades due to improved oncological treatment regimens, it still has a persisting negative impact on future fertility in both girls and boys. The most severe effects do occur with high-dose chemotherapy before autologous bone marrow stem cell transplantation and in the case of total body irradiation. But also radiation of the pelvis and the gonads as well as cytostatic therapy with alkylating agents can lead to premature gonadal insufficiency. To avoid these severe effects in children, adolescents and young adults several fertility preserving techniques have been developed. They are presented and discussed in this chapter of the book. Fertility preserving methods which can be offered to young cancer patients are cryopreservation of ovarian tissue (in prepubescent as well as in postpubescent children), transposition of the ovaries (in the case of a radiotherapy off the pelvis in girls), hormonal gonadotrophin stimulation for retrieval and cryopreservation of oocytes (in postpubescent girls), medical ovarian suppression with GnRH agonists (in postpubescent children) and cryopreservation of semen in postpubescent boys as well as the experimental cryopreservation of testicular tissue in prepubescent boys. More... »

PAGES

97-99

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-030-49140-6_10

DOI

http://dx.doi.org/10.1007/978-3-030-49140-6_10

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1132364295


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Fertility Center Hamburg, Amedes MVZ, Hamburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.490302.c", 
          "name": [
            "Department for Gynaecology, Obstetrics and Reproductive Medicine Saarland University Hospital Homburg, Homburg, Germany", 
            "Fertility Center Hamburg, Amedes MVZ, Hamburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Findeklee", 
        "givenName": "Sebastian", 
        "id": "sg:person.014701702310.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014701702310.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Gynecological Endocrinology and Reproductive Medicine, University Women\u2019s Hospital, Bern, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.411656.1", 
          "name": [
            "Division of Gynecological Endocrinology and Reproductive Medicine, University Women\u2019s Hospital, Bern, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "von Wolff", 
        "givenName": "Michael", 
        "id": "sg:person.0610777233.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610777233.66"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2020-11-06", 
    "datePublishedReg": "2020-11-06", 
    "description": "While the prognosis of cancer diseases has improved during the last decades due to improved oncological treatment regimens, it still has a persisting negative impact on future fertility in both girls and boys. The most severe effects do occur with high-dose chemotherapy before autologous bone marrow stem cell transplantation and in the case of total body irradiation. But also radiation of the pelvis and the gonads as well as cytostatic therapy with alkylating agents can lead to premature gonadal insufficiency. To avoid these severe effects in children, adolescents and young adults several fertility preserving techniques have been developed. They are presented and discussed in this chapter of the book. Fertility preserving methods which can be offered to young cancer patients are cryopreservation of ovarian tissue (in prepubescent as well as in postpubescent children), transposition of the ovaries (in the case of a radiotherapy off the pelvis in girls), hormonal gonadotrophin stimulation for retrieval and cryopreservation of oocytes (in postpubescent girls), medical ovarian suppression with GnRH agonists (in postpubescent children) and cryopreservation of semen in postpubescent boys as well as the experimental cryopreservation of testicular tissue in prepubescent boys.", 
    "editor": [
      {
        "familyName": "Beck", 
        "givenName": "J\u00f6rn D.", 
        "type": "Person"
      }, 
      {
        "familyName": "Bokemeyer", 
        "givenName": "Carsten", 
        "type": "Person"
      }, 
      {
        "familyName": "Langer", 
        "givenName": "Thorsten", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-3-030-49140-6_10", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-3-030-49138-3", 
        "978-3-030-49140-6"
      ], 
      "name": "Late Treatment Effects and Cancer Survivor Care in the Young", 
      "type": "Book"
    }, 
    "keywords": [
      "cancer patients", 
      "autologous bone marrow stem cell transplantation", 
      "bone marrow stem cell transplantation", 
      "marrow stem cell transplantation", 
      "high-dose chemotherapy", 
      "total body irradiation", 
      "stem cell transplantation", 
      "young cancer patients", 
      "medical ovarian suppression", 
      "cryopreservation of oocytes", 
      "ovarian suppression", 
      "GnRH agonist", 
      "cytostatic therapy", 
      "body irradiation", 
      "treatment regimens", 
      "cell transplantation", 
      "gonadotrophin stimulation", 
      "future fertility", 
      "fertility protection", 
      "ovarian tissue", 
      "prepubescent boys", 
      "testicular tissue", 
      "young adults", 
      "cancer disease", 
      "postpubescent boys", 
      "patients", 
      "boys", 
      "adolescents", 
      "severe effects", 
      "tissue", 
      "cryopreservation of semen", 
      "cryopreservation", 
      "regimens", 
      "chemotherapy", 
      "transplantation", 
      "prognosis", 
      "therapy", 
      "agonists", 
      "pelvis", 
      "disease", 
      "gonadal", 
      "fertility", 
      "stimulation", 
      "adults", 
      "ovaries", 
      "childhood", 
      "children", 
      "girls", 
      "oocytes", 
      "effect", 
      "semen", 
      "suppression", 
      "agents", 
      "last decade", 
      "negative impact", 
      "gonads", 
      "transposition", 
      "cases", 
      "protection", 
      "impact", 
      "irradiation", 
      "decades", 
      "radiation", 
      "technique", 
      "method", 
      "chapter", 
      "retrieval", 
      "book"
    ], 
    "name": "Fertility Protection in Childhood, Adolescents and Young Adulthood Cancer Patients", 
    "pagination": "97-99", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1132364295"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-3-030-49140-6_10"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-3-030-49140-6_10", 
      "https://app.dimensions.ai/details/publication/pub.1132364295"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-10-01T06:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/chapter/chapter_33.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-3-030-49140-6_10"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-030-49140-6_10'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-030-49140-6_10'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-030-49140-6_10'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-030-49140-6_10'


 

This table displays all metadata directly associated to this object as RDF triples.

152 TRIPLES      22 PREDICATES      92 URIs      84 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-3-030-49140-6_10 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 anzsrc-for:1114
4 schema:author Nd1aa4de2a192426387fb82a255a981c1
5 schema:datePublished 2020-11-06
6 schema:datePublishedReg 2020-11-06
7 schema:description While the prognosis of cancer diseases has improved during the last decades due to improved oncological treatment regimens, it still has a persisting negative impact on future fertility in both girls and boys. The most severe effects do occur with high-dose chemotherapy before autologous bone marrow stem cell transplantation and in the case of total body irradiation. But also radiation of the pelvis and the gonads as well as cytostatic therapy with alkylating agents can lead to premature gonadal insufficiency. To avoid these severe effects in children, adolescents and young adults several fertility preserving techniques have been developed. They are presented and discussed in this chapter of the book. Fertility preserving methods which can be offered to young cancer patients are cryopreservation of ovarian tissue (in prepubescent as well as in postpubescent children), transposition of the ovaries (in the case of a radiotherapy off the pelvis in girls), hormonal gonadotrophin stimulation for retrieval and cryopreservation of oocytes (in postpubescent girls), medical ovarian suppression with GnRH agonists (in postpubescent children) and cryopreservation of semen in postpubescent boys as well as the experimental cryopreservation of testicular tissue in prepubescent boys.
8 schema:editor N504e7ebfabc741cb9a6c5aee7b5c3801
9 schema:genre chapter
10 schema:isAccessibleForFree false
11 schema:isPartOf N6e14b4863cb946cd9ce2c1e7383ce96d
12 schema:keywords GnRH agonist
13 adolescents
14 adults
15 agents
16 agonists
17 autologous bone marrow stem cell transplantation
18 body irradiation
19 bone marrow stem cell transplantation
20 book
21 boys
22 cancer disease
23 cancer patients
24 cases
25 cell transplantation
26 chapter
27 chemotherapy
28 childhood
29 children
30 cryopreservation
31 cryopreservation of oocytes
32 cryopreservation of semen
33 cytostatic therapy
34 decades
35 disease
36 effect
37 fertility
38 fertility protection
39 future fertility
40 girls
41 gonadal
42 gonadotrophin stimulation
43 gonads
44 high-dose chemotherapy
45 impact
46 irradiation
47 last decade
48 marrow stem cell transplantation
49 medical ovarian suppression
50 method
51 negative impact
52 oocytes
53 ovarian suppression
54 ovarian tissue
55 ovaries
56 patients
57 pelvis
58 postpubescent boys
59 prepubescent boys
60 prognosis
61 protection
62 radiation
63 regimens
64 retrieval
65 semen
66 severe effects
67 stem cell transplantation
68 stimulation
69 suppression
70 technique
71 testicular tissue
72 therapy
73 tissue
74 total body irradiation
75 transplantation
76 transposition
77 treatment regimens
78 young adults
79 young cancer patients
80 schema:name Fertility Protection in Childhood, Adolescents and Young Adulthood Cancer Patients
81 schema:pagination 97-99
82 schema:productId N1ea60ddb645c4df1bc64346e3d10cbab
83 Nb7ce61e538b94c76a52e6c5a2c0c4539
84 schema:publisher Nc9be76d0f89f4c5791429e4a1a04c7f7
85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1132364295
86 https://doi.org/10.1007/978-3-030-49140-6_10
87 schema:sdDatePublished 2022-10-01T06:57
88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
89 schema:sdPublisher Nb9345f4e5e214de8a69b528d9d0143b6
90 schema:url https://doi.org/10.1007/978-3-030-49140-6_10
91 sgo:license sg:explorer/license/
92 sgo:sdDataset chapters
93 rdf:type schema:Chapter
94 N1ea60ddb645c4df1bc64346e3d10cbab schema:name dimensions_id
95 schema:value pub.1132364295
96 rdf:type schema:PropertyValue
97 N2b2863ece82149ba86417cf33e6cc392 schema:familyName Beck
98 schema:givenName Jörn D.
99 rdf:type schema:Person
100 N504e7ebfabc741cb9a6c5aee7b5c3801 rdf:first N2b2863ece82149ba86417cf33e6cc392
101 rdf:rest Nbada21754e294d3e8f5815ee7009c49f
102 N61616ab387ef482b8d488e0712644aae rdf:first sg:person.0610777233.66
103 rdf:rest rdf:nil
104 N6e14b4863cb946cd9ce2c1e7383ce96d schema:isbn 978-3-030-49138-3
105 978-3-030-49140-6
106 schema:name Late Treatment Effects and Cancer Survivor Care in the Young
107 rdf:type schema:Book
108 N813bc0dceb874ba5aa9296d3d8638b27 schema:familyName Bokemeyer
109 schema:givenName Carsten
110 rdf:type schema:Person
111 Naab7b43382ba49e3a7788b74f232b5ad schema:familyName Langer
112 schema:givenName Thorsten
113 rdf:type schema:Person
114 Nb7ce61e538b94c76a52e6c5a2c0c4539 schema:name doi
115 schema:value 10.1007/978-3-030-49140-6_10
116 rdf:type schema:PropertyValue
117 Nb9345f4e5e214de8a69b528d9d0143b6 schema:name Springer Nature - SN SciGraph project
118 rdf:type schema:Organization
119 Nbada21754e294d3e8f5815ee7009c49f rdf:first N813bc0dceb874ba5aa9296d3d8638b27
120 rdf:rest Nc4a1a922aae0451e9203cb1c6c0ad317
121 Nc4a1a922aae0451e9203cb1c6c0ad317 rdf:first Naab7b43382ba49e3a7788b74f232b5ad
122 rdf:rest rdf:nil
123 Nc9be76d0f89f4c5791429e4a1a04c7f7 schema:name Springer Nature
124 rdf:type schema:Organisation
125 Nd1aa4de2a192426387fb82a255a981c1 rdf:first sg:person.014701702310.07
126 rdf:rest N61616ab387ef482b8d488e0712644aae
127 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
128 schema:name Medical and Health Sciences
129 rdf:type schema:DefinedTerm
130 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
131 schema:name Oncology and Carcinogenesis
132 rdf:type schema:DefinedTerm
133 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
134 schema:name Paediatrics and Reproductive Medicine
135 rdf:type schema:DefinedTerm
136 sg:person.014701702310.07 schema:affiliation grid-institutes:grid.490302.c
137 schema:familyName Findeklee
138 schema:givenName Sebastian
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014701702310.07
140 rdf:type schema:Person
141 sg:person.0610777233.66 schema:affiliation grid-institutes:grid.411656.1
142 schema:familyName von Wolff
143 schema:givenName Michael
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610777233.66
145 rdf:type schema:Person
146 grid-institutes:grid.411656.1 schema:alternateName Division of Gynecological Endocrinology and Reproductive Medicine, University Women’s Hospital, Bern, Switzerland
147 schema:name Division of Gynecological Endocrinology and Reproductive Medicine, University Women’s Hospital, Bern, Switzerland
148 rdf:type schema:Organization
149 grid-institutes:grid.490302.c schema:alternateName Fertility Center Hamburg, Amedes MVZ, Hamburg, Germany
150 schema:name Department for Gynaecology, Obstetrics and Reproductive Medicine Saarland University Hospital Homburg, Homburg, Germany
151 Fertility Center Hamburg, Amedes MVZ, Hamburg, Germany
152 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...