Premature Ovarian Insufficiency: Hormone Replacement Therapy and Follow-Up View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2020-07-01

AUTHORS

Volker Ziller , Petra Stute , Michael von Wolff

ABSTRACT

This chapter describes causes, diagnostic and therapeutic procedures in the event of premature ovarian insufficiency (POI) induced either by gonadotoxic treatments or caused by genetic defects, autoimmunological disease, infection, surgical interventions, etc. POI is defined by oligo-/amenorrhea for at least 4 months and a serum concentration of FSH > 25 IU/I measured twice at least 4 weeks apart in women before the age of 40 years. Women with POI generally show the typical symptoms of menopause such as cycle disorders, hot flushes, vaginal dryness, sleep disorders and psychological changes such as nervousness, irritability, fatigue and others. Fertility of POI patients is severely reduced and total infertility can occur. The lack of estrogen leads to considerable long-term consequences. These are primarily effects on bone metabolism, the cardiovascular system and changes in the nervous system that result in a reduced life expectancy. The misinterpretation of the WHI (Women’s Health Initiative) study has led to an irrational fear of hormone replacement therapy (HRT) for both patients and doctors. However, with the increased risk associated with POI/early menopause HRT is advantageous if the oncological and other contraindications to HRT are followed. The risks of non-HRT must therefore be weighed individually against the risks of HRT. More... »

PAGES

273-282

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-030-47568-0_31

DOI

http://dx.doi.org/10.1007/978-3-030-47568-0_31

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1128877367


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Dep. Gyn. Endocrinology and Reproductive Medicine, Clinic for Gynaecology and Obstetrics, University Hospital Giessen and Marburg (UKGM), Marburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411067.5", 
          "name": [
            "Dep. Gyn. Endocrinology and Reproductive Medicine, Clinic for Gynaecology and Obstetrics, University Hospital Giessen and Marburg (UKGM), Marburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ziller", 
        "givenName": "Volker", 
        "id": "sg:person.01157414011.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157414011.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Gynaecological Endocrinology and Reproductive Medicine, University Women\u2019s Hospital, University of Bern, Bern, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.411656.1", 
          "name": [
            "Division of Gynaecological Endocrinology and Reproductive Medicine, University Women\u2019s Hospital, University of Bern, Bern, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stute", 
        "givenName": "Petra", 
        "id": "sg:person.01266270133.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266270133.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Gynaecological Endocrinology and Reproductive Medicine, University Women\u2019s Hospital, University of Bern, Bern, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.411656.1", 
          "name": [
            "Division of Gynaecological Endocrinology and Reproductive Medicine, University Women\u2019s Hospital, University of Bern, Bern, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "von Wolff", 
        "givenName": "Michael", 
        "id": "sg:person.0610777233.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610777233.66"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2020-07-01", 
    "datePublishedReg": "2020-07-01", 
    "description": "This chapter describes causes, diagnostic and therapeutic procedures in the event of premature ovarian insufficiency (POI) induced either by gonadotoxic treatments or caused by genetic defects, autoimmunological disease, infection, surgical interventions, etc. POI is defined by oligo-/amenorrhea for at least 4\u00a0months and a serum concentration of FSH\u00a0>\u00a025\u00a0IU/I measured twice at least 4\u00a0weeks apart in women before the age of 40\u00a0years. Women with POI generally show the typical symptoms of menopause such as cycle disorders, hot flushes, vaginal dryness, sleep disorders and psychological changes such as nervousness, irritability, fatigue and others. Fertility of POI patients is severely reduced and total infertility can occur. The lack of estrogen leads to considerable long-term consequences. These are primarily effects on bone metabolism, the cardiovascular system and changes in the nervous system that result in a reduced life expectancy. The misinterpretation of the WHI (Women\u2019s Health Initiative) study has led to an irrational fear of hormone replacement therapy (HRT) for both patients and doctors. However, with the increased risk associated with POI/early menopause HRT is advantageous if the oncological and other contraindications to HRT are followed. The risks of non-HRT must therefore be weighed individually against the risks of HRT.", 
    "editor": [
      {
        "familyName": "von Wolff", 
        "givenName": "Michael", 
        "type": "Person"
      }, 
      {
        "familyName": "Nawroth", 
        "givenName": "Frank", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-3-030-47568-0_31", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-3-030-47567-3", 
        "978-3-030-47568-0"
      ], 
      "name": "Fertility Preservation in Oncological and Non-Oncological Diseases", 
      "type": "Book"
    }, 
    "keywords": [
      "hormone replacement therapy", 
      "premature ovarian insufficiency", 
      "replacement therapy", 
      "risks of HRT", 
      "menopause hormone replacement therapy", 
      "lack of estrogen", 
      "reduced life expectancy", 
      "hot flushes", 
      "vaginal dryness", 
      "WHI study", 
      "gonadotoxic treatment", 
      "surgical intervention", 
      "POI patients", 
      "serum concentrations", 
      "bone metabolism", 
      "Follow-up", 
      "autoimmunological diseases", 
      "ovarian insufficiency", 
      "sleep disorders", 
      "long-term consequences", 
      "therapeutic procedures", 
      "nervous system", 
      "cycle disorders", 
      "cardiovascular system", 
      "total infertility", 
      "typical symptoms", 
      "life expectancy", 
      "genetic defects", 
      "patients", 
      "therapy", 
      "risk", 
      "women", 
      "disorders", 
      "psychological changes", 
      "irrational fear", 
      "contraindications", 
      "menopause", 
      "FSH", 
      "infertility", 
      "estrogen", 
      "insufficiency", 
      "symptoms", 
      "infection", 
      "irritability", 
      "disease", 
      "IU", 
      "weeks", 
      "months", 
      "intervention", 
      "age", 
      "treatment", 
      "doctors", 
      "cause", 
      "metabolism", 
      "nervousness", 
      "expectancy", 
      "dryness", 
      "fatigue", 
      "changes", 
      "flushes", 
      "years", 
      "fertility", 
      "study", 
      "fear", 
      "events", 
      "lack", 
      "defects", 
      "procedure", 
      "effect", 
      "concentration", 
      "misinterpretation", 
      "consequences", 
      "system", 
      "chapter"
    ], 
    "name": "Premature Ovarian Insufficiency: Hormone Replacement Therapy and Follow-Up", 
    "pagination": "273-282", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1128877367"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-3-030-47568-0_31"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-3-030-47568-0_31", 
      "https://app.dimensions.ai/details/publication/pub.1128877367"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-06-01T22:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/chapter/chapter_290.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-3-030-47568-0_31"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-030-47568-0_31'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-030-47568-0_31'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-030-47568-0_31'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-030-47568-0_31'


 

This table displays all metadata directly associated to this object as RDF triples.

160 TRIPLES      23 PREDICATES      99 URIs      91 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-3-030-47568-0_31 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 anzsrc-for:1114
4 schema:author N08712dd9844b442c98c0e6d15b3d8dc5
5 schema:datePublished 2020-07-01
6 schema:datePublishedReg 2020-07-01
7 schema:description This chapter describes causes, diagnostic and therapeutic procedures in the event of premature ovarian insufficiency (POI) induced either by gonadotoxic treatments or caused by genetic defects, autoimmunological disease, infection, surgical interventions, etc. POI is defined by oligo-/amenorrhea for at least 4 months and a serum concentration of FSH > 25 IU/I measured twice at least 4 weeks apart in women before the age of 40 years. Women with POI generally show the typical symptoms of menopause such as cycle disorders, hot flushes, vaginal dryness, sleep disorders and psychological changes such as nervousness, irritability, fatigue and others. Fertility of POI patients is severely reduced and total infertility can occur. The lack of estrogen leads to considerable long-term consequences. These are primarily effects on bone metabolism, the cardiovascular system and changes in the nervous system that result in a reduced life expectancy. The misinterpretation of the WHI (Women’s Health Initiative) study has led to an irrational fear of hormone replacement therapy (HRT) for both patients and doctors. However, with the increased risk associated with POI/early menopause HRT is advantageous if the oncological and other contraindications to HRT are followed. The risks of non-HRT must therefore be weighed individually against the risks of HRT.
8 schema:editor Ne2b044c011c44d61a9a7e481aec825f0
9 schema:genre chapter
10 schema:inLanguage en
11 schema:isAccessibleForFree false
12 schema:isPartOf Ndb836c57a4644f2c9e6a72b993dda80a
13 schema:keywords FSH
14 Follow-up
15 IU
16 POI patients
17 WHI study
18 age
19 autoimmunological diseases
20 bone metabolism
21 cardiovascular system
22 cause
23 changes
24 chapter
25 concentration
26 consequences
27 contraindications
28 cycle disorders
29 defects
30 disease
31 disorders
32 doctors
33 dryness
34 effect
35 estrogen
36 events
37 expectancy
38 fatigue
39 fear
40 fertility
41 flushes
42 genetic defects
43 gonadotoxic treatment
44 hormone replacement therapy
45 hot flushes
46 infection
47 infertility
48 insufficiency
49 intervention
50 irrational fear
51 irritability
52 lack
53 lack of estrogen
54 life expectancy
55 long-term consequences
56 menopause
57 menopause hormone replacement therapy
58 metabolism
59 misinterpretation
60 months
61 nervous system
62 nervousness
63 ovarian insufficiency
64 patients
65 premature ovarian insufficiency
66 procedure
67 psychological changes
68 reduced life expectancy
69 replacement therapy
70 risk
71 risks of HRT
72 serum concentrations
73 sleep disorders
74 study
75 surgical intervention
76 symptoms
77 system
78 therapeutic procedures
79 therapy
80 total infertility
81 treatment
82 typical symptoms
83 vaginal dryness
84 weeks
85 women
86 years
87 schema:name Premature Ovarian Insufficiency: Hormone Replacement Therapy and Follow-Up
88 schema:pagination 273-282
89 schema:productId N9ec705d5604e4877970cc4a97eaafbf8
90 Nabfab15b2f1a438291cadde43157dc81
91 schema:publisher N72886ec4b2ce414ca3d6afd79d2c2dbf
92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1128877367
93 https://doi.org/10.1007/978-3-030-47568-0_31
94 schema:sdDatePublished 2022-06-01T22:31
95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
96 schema:sdPublisher N771a17ede44646b99d560ad2f974dfd4
97 schema:url https://doi.org/10.1007/978-3-030-47568-0_31
98 sgo:license sg:explorer/license/
99 sgo:sdDataset chapters
100 rdf:type schema:Chapter
101 N08712dd9844b442c98c0e6d15b3d8dc5 rdf:first sg:person.01157414011.31
102 rdf:rest N0a2e4e02ad8246d39eacaf2ab39e421d
103 N0a2e4e02ad8246d39eacaf2ab39e421d rdf:first sg:person.01266270133.70
104 rdf:rest N98288a3be3a04e579de6ba212f9912f9
105 N6a27de6e40164e4ca50a398077281e32 rdf:first Ne58f880deeb9414c826bab3a5bbd6aa1
106 rdf:rest rdf:nil
107 N72886ec4b2ce414ca3d6afd79d2c2dbf schema:name Springer Nature
108 rdf:type schema:Organisation
109 N771a17ede44646b99d560ad2f974dfd4 schema:name Springer Nature - SN SciGraph project
110 rdf:type schema:Organization
111 N7f554944d63e4a2496640ab2ab70e195 schema:familyName von Wolff
112 schema:givenName Michael
113 rdf:type schema:Person
114 N98288a3be3a04e579de6ba212f9912f9 rdf:first sg:person.0610777233.66
115 rdf:rest rdf:nil
116 N9ec705d5604e4877970cc4a97eaafbf8 schema:name dimensions_id
117 schema:value pub.1128877367
118 rdf:type schema:PropertyValue
119 Nabfab15b2f1a438291cadde43157dc81 schema:name doi
120 schema:value 10.1007/978-3-030-47568-0_31
121 rdf:type schema:PropertyValue
122 Ndb836c57a4644f2c9e6a72b993dda80a schema:isbn 978-3-030-47567-3
123 978-3-030-47568-0
124 schema:name Fertility Preservation in Oncological and Non-Oncological Diseases
125 rdf:type schema:Book
126 Ne2b044c011c44d61a9a7e481aec825f0 rdf:first N7f554944d63e4a2496640ab2ab70e195
127 rdf:rest N6a27de6e40164e4ca50a398077281e32
128 Ne58f880deeb9414c826bab3a5bbd6aa1 schema:familyName Nawroth
129 schema:givenName Frank
130 rdf:type schema:Person
131 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
132 schema:name Medical and Health Sciences
133 rdf:type schema:DefinedTerm
134 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
135 schema:name Clinical Sciences
136 rdf:type schema:DefinedTerm
137 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
138 schema:name Paediatrics and Reproductive Medicine
139 rdf:type schema:DefinedTerm
140 sg:person.01157414011.31 schema:affiliation grid-institutes:grid.411067.5
141 schema:familyName Ziller
142 schema:givenName Volker
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157414011.31
144 rdf:type schema:Person
145 sg:person.01266270133.70 schema:affiliation grid-institutes:grid.411656.1
146 schema:familyName Stute
147 schema:givenName Petra
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266270133.70
149 rdf:type schema:Person
150 sg:person.0610777233.66 schema:affiliation grid-institutes:grid.411656.1
151 schema:familyName von Wolff
152 schema:givenName Michael
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610777233.66
154 rdf:type schema:Person
155 grid-institutes:grid.411067.5 schema:alternateName Dep. Gyn. Endocrinology and Reproductive Medicine, Clinic for Gynaecology and Obstetrics, University Hospital Giessen and Marburg (UKGM), Marburg, Germany
156 schema:name Dep. Gyn. Endocrinology and Reproductive Medicine, Clinic for Gynaecology and Obstetrics, University Hospital Giessen and Marburg (UKGM), Marburg, Germany
157 rdf:type schema:Organization
158 grid-institutes:grid.411656.1 schema:alternateName Division of Gynaecological Endocrinology and Reproductive Medicine, University Women’s Hospital, University of Bern, Bern, Switzerland
159 schema:name Division of Gynaecological Endocrinology and Reproductive Medicine, University Women’s Hospital, University of Bern, Bern, Switzerland
160 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...