Salivary Bioscience and Periodontal Medicine View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2020-04-08

AUTHORS

Chen Xuan Wei , Yanbao Yu , Gajender Aleti , Manny Torralba , Anna Edlund , Karen E. Nelson , Marcelo Freire

ABSTRACT

Mammalian saliva carries a precise developmental and biological program that defines the function of multiple organs including oral and periodontal tissues (tissues surrounding the tooth). Saliva is at the interface of dynamic interactions between microbial ecosystems and oral immune cells. Dysregulation of saliva physiology has an impact on oral and systemic health. Elevated inflammatory cytokines in saliva, for example, activates dysbiosis (disease) of periodontal tissues, feeding forward tissue inflammation, leading to oral tissue loss. Complex host–microbiome interactions modulate pathological transitions including gingivitis, periodontal diseases, and oral cancer. However, mechanisms involving these interactions are poorly understood at the molecular level. Hence, the overall understanding of salivary biosciences, in the context of periodontal health and disease, is crucial to oral medicine, microbiology, translational sciences, and human health. High-throughput screening techniques, presented here, allow for the identification and quantification of salivary molecular information and its functional kinetics. With current available “multi-omic” tools, we highlight the importance of saliva in precision dental medicine and in influencing dynamic interactions of the periodontium. This chapter reviews fundamental roles of saliva in periodontal health with particular focus given to oral microbiome, tissue inflammation, resolution signals, local-systemic circuitry, and periodontal dysbiosis. More... »

PAGES

419-447

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-030-35784-9_18

DOI

http://dx.doi.org/10.1007/978-3-030-35784-9_18

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1126269186


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