Bonediol Production in Bonellia macrocarpa Hairy Root Culture View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2020-12-04

AUTHORS

Peggy Elizabeth Alvarez-Gutiérrez , Luis Alberto Ruiz-Ramirez , Gregorio del Carmen Godoy-Hernández , Federico Antonio Gutiérrez-Miceli

ABSTRACT

The genus Bonellia belongs to the family Theophrastaceae, which consists of 22 species distributed in Mesoamerica, in the north and in the west of South America and the Greater Antilles. Bonellia macrocarpa (Cavanilles) Ståhl and Källersjö has generated a great interest derived from the biological activities that present the secondary metabolites of this species. Bonediol is an alkyl catechol produced by Bonellia macrocarpa with antiproliferative activity against cell lines of nasopharynx carcinoma. Hairy root culture is an alternative for study and production of bonediol. The aim of this work is to present a revision on the induction of Bonellia macrocarpa hairy root culture as an alternative strategy for bonediol production. For the production of hairy roots of B. macrocarpa, some factors have an effect on the production, such as the explant type and chemical additives on the percent of explants forming roots. The rhizogenic response of cotyledon, hypocotyl, and roots was different. For cotyledon explants, the rhizogenic response was observed from the 4th to the 6th week; however, for hypocotyl explants, the rhizogenic response was observed from the 5th to the 6th week, and finally for the root explants, the rhizogenic response was observed from the 3rd to the 4th week. Two chemical auxiliaries, glutamine and acetosyringone, had a statistically significant effect on percent of explants forming roots. The addition of 100 mg/L glutamine or 100 μM acetosyringone to the culture media generated the highest percent of explants forming roots in cotyledon; in contrast, other factors such as cysteine, dithiothreitol, and A. rhizogenes density did not have a statistically significant effect on the response. Bonediol can be produced via hairy root culture. Methanol extracts of hairy roots can produce 2.78 mg bonediol/g dried weight of transformed root, and therefore Bonellia macrocarpa hairy root culture is an alternative for bonediol production; however, it is necessary to carry out more studies that allow the scaling of the process in order to have biomass in large quantities. More... »

PAGES

585-605

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-030-30185-9_24

DOI

http://dx.doi.org/10.1007/978-3-030-30185-9_24

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1133092679


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