Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2019-12-20

AUTHORS

Natalia Nedelsky , Petric Kuballa , Adam B. Castoreno , Ramnik J. Xavier

ABSTRACT

Studies using human genetics have identified more than 160 loci that affect the risk of developing inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC). Several of these genes have been found to play key roles in the process of autophagy, a lysosome-based degradation pathway. Although historically considered to be a relatively nonselective process of degradation of cytosolic contents, autophagy has recently been revealed to have several selective and immune-specific functions that are relevant to the maintenance of intestinal homeostasis, including xenophagy, mitophagy, antigen presentation, secretion, and inflammasome regulation. In this chapter, we review the evidence that links autophagy-related genes, their immune-specific functions, and possible mechanisms of IBD pathogenesis. We summarize the basic molecular events underlying general and selective autophagy, and present evidence suggesting possible pathogenic mechanisms revealed by studies of IBD-associated risk alleles of ATG16L1 and IRGM. Finally, we review chemical biology-based experimental approaches for identifying autophagy regulatory pathways that may have implications for the development of therapeutics. More... »

PAGES

305-328

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-030-28703-0_14

DOI

http://dx.doi.org/10.1007/978-3-030-28703-0_14

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1123538765


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