Cultivated Cells in the Treatment of Corneal Diseases View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2019-11-01

AUTHORS

Shigeru Kinoshita , Morio Ueno

ABSTRACT

This chapter mainly describes a cell-based treatment focused on a cultured corneal endothelial cell (CEC)-injection therapy, and it is devided into three parts; i.e., Background, Current State, and Future Directions. The background involves the successful culture of CECs in primates, animal-model experiments in which a cultured CEC sheet is used, and modification of the cultivation protocol and its use for CEC-injection therapy in an animal-model experiment. The current state involves cultured human CECs (HCECs) for clinical use, the clinical trials of cultured HCEC-injection therapy, the evaluation of the antigenecity of allogeneic cells and the fate of escaped cells from the eye post injection. As for the future directions, the ‘seeds and soil’ theory in the clinical setting, the combination therapy ewith ROCK-inhibitor eye drops, and the advancement of cell delivery and cell storage are all discussed. More... »

PAGES

215-224

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-030-25335-6_18

DOI

http://dx.doi.org/10.1007/978-3-030-25335-6_18

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1122229738


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