Current Challenges in the Management of Sepsis in ICUs in Resource-Poor Settings and Suggestions for the Future View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2019-02-09

AUTHORS

Marcus J. Schultz , Martin W. Dünser , Arjen M. Dondorp , Neill K. J. Adhikari , Shivakumar Iyer , Arthur Kwizera , Yoel Lubell , Alfred Papali , Luigi Pisani , Elisabeth D. Riviello , Derek C. Angus , Luciano C. Azevedo , Timothy Baker , Janet V. Diaz , Emir Festic , Rashan Haniffa , Randeep Jawa , Shevin T. Jacob , Niranjan Kissoon , Rakesh Lodha , Ignacio Martin-Loeches , Ganbold Lundeg , David Misango , Mervyn Mer , Sanjib Mohanty , Srinivas Murthy , Ndidiamaka Musa , Jane Nakibuuka , Ary Serpa Neto , NT Hoang Mai , Binh Nguyen Thien , Rajyabardhan Pattnaik , Jason Phua , Jacobus Preller , Pedro Povoa , Suchitra Ranjit , Daniel Talmor , Jonarthan Thevanayagam , C. Louise Thwaites

ABSTRACT

Sepsis is a major cause of critical illness worldwide, especially in resource-poor settings. Intensive care units (ICUs) in low- and middle-income countries (LMICs) face many challenges that could affect patient outcome. The aim of this review is to describe differences between resource-poor and resource-rich settings regarding the epidemiology, pathophysiology, economics, and research aspects of sepsis. We restricted this manuscript to the ICU setting although we are aware that many sepsis patients in LMICs are treated outside an ICU. Although many bacterial pathogens causing sepsis in LMICs are similar to those in high-income countries, resistance patterns to antimicrobial drugs can be very different; in addition, causes of sepsis in LMICs often include tropical diseases in which direct damaging effects of pathogens and their products can be more important than the host response. There are differences in ICU capacities around the world; not surprisingly the lowest capacities are found in LMICs with important heterogeneity within individual LMICs. Although many aspects of sepsis management developed in resource-rich countries are applicable in LMICs, implementation requires strong consideration of cost implications and important differences in resources. Addressing both disease-specific and setting-specific factors is important to improve performance of ICUs in LMICs. Although critical care for sepsis is likely cost-effective in LMIC setting, more detailed evaluation at both a macro- and micro-economy level is necessary. Sepsis management in resource-limited settings is a largely unexplored frontier with important opportunities for research, training, and other initiatives for improvement. More... »

PAGES

1-24

Book

TITLE

Sepsis Management in Resource-limited Settings

ISBN

978-3-030-03142-8
978-3-030-03143-5

Author Affiliations

  • Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
  • Kepler University Hospital, Johannes Kepler University, Linz, Austria
  • Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
  • Bharati Vidyapeeth Deemed University Medical College, Pune, India
  • Mulago National Referral Hospital, Kampala, Uganda
  • Division of Pulmonary and Critical Care Medicine, Atrium Health, Charlotte, NC, USA
  • Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
  • University of Pittsburgh, Pittsburgh, PA, USA
  • Hospital Sirio-Libanes, Saõ Paulo, Brazil
  • Karolinska Institute, Stockholm, Sweden
  • California Pacific Medical Center, San Francisco, CA, USA
  • Mayo Clinic, Jacksonville, FL, USA
  • Mahidol University, Bangkok, Thailand
  • Stony Brook University Medical Center, Stony Brook, NY, USA
  • Liverpool School of Tropical Medicine, Liverpool, UK
  • British Columbia Children’s Hospital, Vancouver, BC, Canada
  • All India Institute of Medical Science, Delhi, India
  • St. James’s University Hospital, Dublin, Ireland
  • Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia
  • Aga Khan University Hospital, Nairobi, Kenya
  • Johannesburg Hospital, University of the Witwatersrand, Johannesburg, South Africa
  • Ispat General Hospital, Rourkela, Odisha, India
  • Seattle Children’s Hospital, University of Washington, Washington, WA, USA
  • Medical Intensive Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
  • Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
  • Trung Vuong Hospital, Ho Chi Minh City, Vietnam
  • National University Hospital, Singapore, Singapore
  • Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
  • Hospital de Sao Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal
  • Appolo Hospitals, Chennai, India
  • Mzuzu Central Hospital, Mzuzu, Malawi
  • Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-030-03143-5_1

    DOI

    http://dx.doi.org/10.1007/978-3-030-03143-5_1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112026912


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/14", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Economics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1402", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Applied Economics", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.7177.6", 
              "name": [
                "Mahidol University, Bangkok, Thailand", 
                "Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schultz", 
            "givenName": "Marcus J.", 
            "id": "sg:person.01007146366.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007146366.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kepler University Hospital, Johannes Kepler University, Linz, Austria", 
              "id": "http://www.grid.ac/institutes/grid.9970.7", 
              "name": [
                "Kepler University Hospital, Johannes Kepler University, Linz, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "D\u00fcnser", 
            "givenName": "Martin W.", 
            "id": "sg:person.0661420277.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661420277.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.7177.6", 
              "name": [
                "Mahidol University, Bangkok, Thailand", 
                "Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dondorp", 
            "givenName": "Arjen M.", 
            "id": "sg:person.01162317707.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162317707.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada", 
              "id": "http://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Adhikari", 
            "givenName": "Neill K. J.", 
            "id": "sg:person.013160470014.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013160470014.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Bharati Vidyapeeth Deemed University Medical College, Pune, India", 
              "id": "http://www.grid.ac/institutes/grid.411681.b", 
              "name": [
                "Bharati Vidyapeeth Deemed University Medical College, Pune, India"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Iyer", 
            "givenName": "Shivakumar", 
            "id": "sg:person.01362157550.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362157550.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mulago National Referral Hospital, Kampala, Uganda", 
              "id": "http://www.grid.ac/institutes/grid.416252.6", 
              "name": [
                "Mulago National Referral Hospital, Kampala, Uganda"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kwizera", 
            "givenName": "Arthur", 
            "id": "sg:person.01100610423.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100610423.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.7177.6", 
              "name": [
                "Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lubell", 
            "givenName": "Yoel", 
            "id": "sg:person.0772543414.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772543414.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Pulmonary and Critical Care Medicine, Atrium Health, Charlotte, NC, USA", 
              "id": "http://www.grid.ac/institutes/grid.427669.8", 
              "name": [
                "University of Maryland School of Medicine, Baltimore, MD, USA", 
                "Division of Pulmonary and Critical Care Medicine, Atrium Health, Charlotte, NC, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Papali", 
            "givenName": "Alfred", 
            "id": "sg:person.01343754225.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343754225.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.7177.6", 
              "name": [
                "Mahidol University, Bangkok, Thailand", 
                "Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pisani", 
            "givenName": "Luigi", 
            "id": "sg:person.01055636325.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055636325.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Riviello", 
            "givenName": "Elisabeth D.", 
            "id": "sg:person.0750363462.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750363462.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pittsburgh, Pittsburgh, PA, USA", 
              "id": "http://www.grid.ac/institutes/grid.21925.3d", 
              "name": [
                "University of Pittsburgh, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Angus", 
            "givenName": "Derek C.", 
            "id": "sg:person.01013154627.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013154627.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Sirio-Libanes, Sa\u00f5 Paulo, Brazil", 
              "id": "http://www.grid.ac/institutes/grid.413471.4", 
              "name": [
                "Hospital Sirio-Libanes, Sa\u00f5 Paulo, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Azevedo", 
            "givenName": "Luciano C.", 
            "id": "sg:person.013070162407.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013070162407.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Karolinska Institute, Stockholm, Sweden", 
              "id": "http://www.grid.ac/institutes/grid.4714.6", 
              "name": [
                "Karolinska Institute, Stockholm, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Baker", 
            "givenName": "Timothy", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "California Pacific Medical Center, San Francisco, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.17866.3e", 
              "name": [
                "California Pacific Medical Center, San Francisco, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Diaz", 
            "givenName": "Janet V.", 
            "id": "sg:person.010522476441.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010522476441.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mayo Clinic, Jacksonville, FL, USA", 
              "id": "http://www.grid.ac/institutes/grid.417467.7", 
              "name": [
                "Mayo Clinic, Jacksonville, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Festic", 
            "givenName": "Emir", 
            "id": "sg:person.0761337561.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761337561.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mahidol University, Bangkok, Thailand", 
              "id": "http://www.grid.ac/institutes/grid.10223.32", 
              "name": [
                "Mahidol University, Bangkok, Thailand"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Haniffa", 
            "givenName": "Rashan", 
            "id": "sg:person.01146723623.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146723623.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stony Brook University Medical Center, Stony Brook, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.412695.d", 
              "name": [
                "Stony Brook University Medical Center, Stony Brook, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jawa", 
            "givenName": "Randeep", 
            "id": "sg:person.0657017105.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657017105.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Liverpool School of Tropical Medicine, Liverpool, UK", 
              "id": "http://www.grid.ac/institutes/grid.48004.38", 
              "name": [
                "Liverpool School of Tropical Medicine, Liverpool, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jacob", 
            "givenName": "Shevin T.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "British Columbia Children\u2019s Hospital, Vancouver, BC, Canada", 
              "id": "http://www.grid.ac/institutes/grid.414137.4", 
              "name": [
                "British Columbia Children\u2019s Hospital, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kissoon", 
            "givenName": "Niranjan", 
            "id": "sg:person.014150672735.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014150672735.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "All India Institute of Medical Science, Delhi, India", 
              "id": "http://www.grid.ac/institutes/grid.413618.9", 
              "name": [
                "All India Institute of Medical Science, Delhi, India"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lodha", 
            "givenName": "Rakesh", 
            "id": "sg:person.01075705652.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075705652.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "St. James\u2019s University Hospital, Dublin, Ireland", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "St. James\u2019s University Hospital, Dublin, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Martin-Loeches", 
            "givenName": "Ignacio", 
            "id": "sg:person.01366266562.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366266562.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia", 
              "id": "http://www.grid.ac/institutes/grid.444534.6", 
              "name": [
                "Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lundeg", 
            "givenName": "Ganbold", 
            "id": "sg:person.01051057723.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051057723.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Aga Khan University Hospital, Nairobi, Kenya", 
              "id": "http://www.grid.ac/institutes/grid.411192.e", 
              "name": [
                "Aga Khan University Hospital, Nairobi, Kenya"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Misango", 
            "givenName": "David", 
            "id": "sg:person.013052601043.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013052601043.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Johannesburg Hospital, University of the Witwatersrand, Johannesburg, South Africa", 
              "id": "http://www.grid.ac/institutes/grid.414707.1", 
              "name": [
                "Johannesburg Hospital, University of the Witwatersrand, Johannesburg, South Africa"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mer", 
            "givenName": "Mervyn", 
            "id": "sg:person.01104732461.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104732461.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ispat General Hospital, Rourkela, Odisha, India", 
              "id": "http://www.grid.ac/institutes/grid.440315.7", 
              "name": [
                "Ispat General Hospital, Rourkela, Odisha, India"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mohanty", 
            "givenName": "Sanjib", 
            "id": "sg:person.0610604105.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610604105.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "British Columbia Children\u2019s Hospital, Vancouver, BC, Canada", 
              "id": "http://www.grid.ac/institutes/grid.414137.4", 
              "name": [
                "British Columbia Children\u2019s Hospital, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Murthy", 
            "givenName": "Srinivas", 
            "id": "sg:person.0740103341.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740103341.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Seattle Children\u2019s Hospital, University of Washington, Washington, WA, USA", 
              "id": "http://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Seattle Children\u2019s Hospital, University of Washington, Washington, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Musa", 
            "givenName": "Ndidiamaka", 
            "id": "sg:person.0622142430.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622142430.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mulago National Referral Hospital, Kampala, Uganda", 
              "id": "http://www.grid.ac/institutes/grid.416252.6", 
              "name": [
                "Mulago National Referral Hospital, Kampala, Uganda"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakibuuka", 
            "givenName": "Jane", 
            "id": "sg:person.01261070640.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261070640.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical Intensive Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil", 
              "id": "http://www.grid.ac/institutes/grid.413562.7", 
              "name": [
                "Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands", 
                "Medical Intensive Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Neto", 
            "givenName": "Ary Serpa", 
            "id": "sg:person.01322076671.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322076671.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam", 
              "id": "http://www.grid.ac/institutes/grid.412433.3", 
              "name": [
                "Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mai", 
            "givenName": "NT Hoang", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Trung Vuong Hospital, Ho Chi Minh City, Vietnam", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Trung Vuong Hospital, Ho Chi Minh City, Vietnam"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thien", 
            "givenName": "Binh Nguyen", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ispat General Hospital, Rourkela, Odisha, India", 
              "id": "http://www.grid.ac/institutes/grid.440315.7", 
              "name": [
                "Ispat General Hospital, Rourkela, Odisha, India"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pattnaik", 
            "givenName": "Rajyabardhan", 
            "id": "sg:person.01232635004.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232635004.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University Hospital, Singapore, Singapore", 
              "id": "http://www.grid.ac/institutes/grid.412106.0", 
              "name": [
                "National University Hospital, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Phua", 
            "givenName": "Jason", 
            "id": "sg:person.01345512332.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345512332.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Addenbrooke\u2019s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK", 
              "id": "http://www.grid.ac/institutes/grid.120073.7", 
              "name": [
                "Addenbrooke\u2019s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Preller", 
            "givenName": "Jacobus", 
            "id": "sg:person.013716274643.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013716274643.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital de Sao Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Nova Medical School, CEDOC, New University of Lisbon, Lisbon, Portugal", 
                "Hospital de Sao Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Povoa", 
            "givenName": "Pedro", 
            "id": "sg:person.01167550047.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167550047.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Appolo Hospitals, Chennai, India", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Appolo Hospitals, Chennai, India"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ranjit", 
            "givenName": "Suchitra", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Talmor", 
            "givenName": "Daniel", 
            "id": "sg:person.0600270775.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600270775.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mzuzu Central Hospital, Mzuzu, Malawi", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Mzuzu Central Hospital, Mzuzu, Malawi"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thevanayagam", 
            "givenName": "Jonarthan", 
            "id": "sg:person.01105040674.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105040674.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thwaites", 
            "givenName": "C. Louise", 
            "id": "sg:person.0663401704.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663401704.10"
            ], 
            "type": "Person"
          }
        ], 
        "datePublished": "2019-02-09", 
        "datePublishedReg": "2019-02-09", 
        "description": "Sepsis is a major cause of critical illness worldwide, especially in resource-poor settings. Intensive care units (ICUs) in low- and middle-income countries (LMICs) face many challenges that could affect patient outcome. The aim of this review is to describe differences between resource-poor and resource-rich settings regarding the epidemiology, pathophysiology, economics, and research aspects of sepsis. We restricted this manuscript to the ICU setting although we are aware that many sepsis patients in LMICs are treated outside an ICU. Although many bacterial pathogens causing sepsis in LMICs are similar to those in high-income countries, resistance patterns to antimicrobial drugs can be very different; in addition, causes of sepsis in LMICs often include tropical diseases in which direct damaging effects of pathogens and their products can be more important than the host response. There are differences in ICU capacities around the world; not surprisingly the lowest capacities are found in LMICs with important heterogeneity within individual LMICs. Although many aspects of sepsis management developed in resource-rich countries are applicable in LMICs, implementation requires strong consideration of cost implications and important differences in resources. Addressing both disease-specific and setting-specific factors is important to improve performance of ICUs in LMICs. Although critical care for sepsis is likely cost-effective in LMIC setting, more detailed evaluation at both a macro- and micro-economy level is necessary. Sepsis management in resource-limited settings is a largely unexplored frontier with important opportunities for research, training, and other initiatives for improvement.", 
        "editor": [
          {
            "familyName": "Dondorp", 
            "givenName": "Arjen M.", 
            "type": "Person"
          }, 
          {
            "familyName": "D\u00fcnser", 
            "givenName": "Martin W.", 
            "type": "Person"
          }, 
          {
            "familyName": "Schultz", 
            "givenName": "Marcus J.", 
            "type": "Person"
          }
        ], 
        "genre": "chapter", 
        "id": "sg:pub.10.1007/978-3-030-03143-5_1", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": {
          "isbn": [
            "978-3-030-03142-8", 
            "978-3-030-03143-5"
          ], 
          "name": "Sepsis Management in Resource-limited Settings", 
          "type": "Book"
        }, 
        "keywords": [
          "intensive care unit", 
          "resource-poor settings", 
          "sepsis management", 
          "setting-specific factors", 
          "management of sepsis", 
          "cause of sepsis", 
          "resource-rich countries", 
          "resource-rich settings", 
          "resource-limited settings", 
          "high-income countries", 
          "direct damaging effect", 
          "individual LMICs", 
          "critical illness", 
          "middle-income countries", 
          "sepsis patients", 
          "care unit", 
          "patient outcomes", 
          "critical care", 
          "sepsis", 
          "resistance patterns", 
          "host response", 
          "ICU capacity", 
          "LMIC settings", 
          "tropical diseases", 
          "major cause", 
          "important heterogeneity", 
          "LMICs", 
          "antimicrobial drugs", 
          "countries", 
          "strong consideration", 
          "bacterial pathogens", 
          "cost implications", 
          "damaging effects", 
          "cause", 
          "setting", 
          "important differences", 
          "economics", 
          "patients", 
          "pathophysiology", 
          "pathogens", 
          "management", 
          "illness", 
          "epidemiology", 
          "differences", 
          "detailed evaluation", 
          "important opportunity", 
          "disease", 
          "care", 
          "drugs", 
          "outcomes", 
          "low capacity", 
          "frontier", 
          "review", 
          "aim", 
          "response", 
          "factors", 
          "levels", 
          "implications", 
          "heterogeneity", 
          "evaluation", 
          "resources", 
          "training", 
          "current challenges", 
          "opportunities", 
          "effect", 
          "initiatives", 
          "improvement", 
          "future", 
          "challenges", 
          "capacity", 
          "world", 
          "aspects", 
          "patterns", 
          "addition", 
          "suggestions", 
          "unexplored frontier", 
          "units", 
          "macro", 
          "manuscript", 
          "products", 
          "consideration", 
          "research", 
          "research aspects", 
          "implementation", 
          "performance", 
          "performance of ICUs", 
          "micro-economy level"
        ], 
        "name": "Current Challenges in the Management of Sepsis in ICUs in Resource-Poor Settings and Suggestions for the Future", 
        "pagination": "1-24", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1112026912"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/978-3-030-03143-5_1"
            ]
          }
        ], 
        "publisher": {
          "name": "Springer Nature", 
          "type": "Organisation"
        }, 
        "sameAs": [
          "https://doi.org/10.1007/978-3-030-03143-5_1", 
          "https://app.dimensions.ai/details/publication/pub.1112026912"
        ], 
        "sdDataset": "chapters", 
        "sdDatePublished": "2022-01-01T19:08", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/chapter/chapter_14.jsonl", 
        "type": "Chapter", 
        "url": "https://doi.org/10.1007/978-3-030-03143-5_1"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-030-03143-5_1'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-030-03143-5_1'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-030-03143-5_1'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-030-03143-5_1'


     

    This table displays all metadata directly associated to this object as RDF triples.

    519 TRIPLES      23 PREDICATES      114 URIs      105 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/978-3-030-03143-5_1 schema:about anzsrc-for:11
    2 anzsrc-for:1103
    3 anzsrc-for:14
    4 anzsrc-for:1402
    5 schema:author Ndb6bab0cfb4549d5b859709ea9ee66b8
    6 schema:datePublished 2019-02-09
    7 schema:datePublishedReg 2019-02-09
    8 schema:description Sepsis is a major cause of critical illness worldwide, especially in resource-poor settings. Intensive care units (ICUs) in low- and middle-income countries (LMICs) face many challenges that could affect patient outcome. The aim of this review is to describe differences between resource-poor and resource-rich settings regarding the epidemiology, pathophysiology, economics, and research aspects of sepsis. We restricted this manuscript to the ICU setting although we are aware that many sepsis patients in LMICs are treated outside an ICU. Although many bacterial pathogens causing sepsis in LMICs are similar to those in high-income countries, resistance patterns to antimicrobial drugs can be very different; in addition, causes of sepsis in LMICs often include tropical diseases in which direct damaging effects of pathogens and their products can be more important than the host response. There are differences in ICU capacities around the world; not surprisingly the lowest capacities are found in LMICs with important heterogeneity within individual LMICs. Although many aspects of sepsis management developed in resource-rich countries are applicable in LMICs, implementation requires strong consideration of cost implications and important differences in resources. Addressing both disease-specific and setting-specific factors is important to improve performance of ICUs in LMICs. Although critical care for sepsis is likely cost-effective in LMIC setting, more detailed evaluation at both a macro- and micro-economy level is necessary. Sepsis management in resource-limited settings is a largely unexplored frontier with important opportunities for research, training, and other initiatives for improvement.
    9 schema:editor Nf902624fbaf64b78a4926ffe1bb59437
    10 schema:genre chapter
    11 schema:inLanguage en
    12 schema:isAccessibleForFree true
    13 schema:isPartOf N1fb7d3a63d1748bbaca946b86f68f35d
    14 schema:keywords ICU capacity
    15 LMIC settings
    16 LMICs
    17 addition
    18 aim
    19 antimicrobial drugs
    20 aspects
    21 bacterial pathogens
    22 capacity
    23 care
    24 care unit
    25 cause
    26 cause of sepsis
    27 challenges
    28 consideration
    29 cost implications
    30 countries
    31 critical care
    32 critical illness
    33 current challenges
    34 damaging effects
    35 detailed evaluation
    36 differences
    37 direct damaging effect
    38 disease
    39 drugs
    40 economics
    41 effect
    42 epidemiology
    43 evaluation
    44 factors
    45 frontier
    46 future
    47 heterogeneity
    48 high-income countries
    49 host response
    50 illness
    51 implementation
    52 implications
    53 important differences
    54 important heterogeneity
    55 important opportunity
    56 improvement
    57 individual LMICs
    58 initiatives
    59 intensive care unit
    60 levels
    61 low capacity
    62 macro
    63 major cause
    64 management
    65 management of sepsis
    66 manuscript
    67 micro-economy level
    68 middle-income countries
    69 opportunities
    70 outcomes
    71 pathogens
    72 pathophysiology
    73 patient outcomes
    74 patients
    75 patterns
    76 performance
    77 performance of ICUs
    78 products
    79 research
    80 research aspects
    81 resistance patterns
    82 resource-limited settings
    83 resource-poor settings
    84 resource-rich countries
    85 resource-rich settings
    86 resources
    87 response
    88 review
    89 sepsis
    90 sepsis management
    91 sepsis patients
    92 setting
    93 setting-specific factors
    94 strong consideration
    95 suggestions
    96 training
    97 tropical diseases
    98 unexplored frontier
    99 units
    100 world
    101 schema:name Current Challenges in the Management of Sepsis in ICUs in Resource-Poor Settings and Suggestions for the Future
    102 schema:pagination 1-24
    103 schema:productId N4dddc9e6b577454494773c6467f9b7df
    104 Nffd4ffb4076645079af53dbc4f4d7580
    105 schema:publisher N4092d30295c14e8493fad0995891df8b
    106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112026912
    107 https://doi.org/10.1007/978-3-030-03143-5_1
    108 schema:sdDatePublished 2022-01-01T19:08
    109 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    110 schema:sdPublisher N3845f1f85d7449b1bc8a1e1b24ecc6b7
    111 schema:url https://doi.org/10.1007/978-3-030-03143-5_1
    112 sgo:license sg:explorer/license/
    113 sgo:sdDataset chapters
    114 rdf:type schema:Chapter
    115 N040481cb4dae493dabae84f44206a3ba rdf:first N9babfec902f64cdc974a3c45289b8a98
    116 rdf:rest Nd929de7b7f394f5cb80172b14c88aac9
    117 N07350801643746f1ae1f6886e5610df6 rdf:first sg:person.01013154627.14
    118 rdf:rest Nbc9a7dac558242a9b6a5a6d9ffe8a1b5
    119 N144e85f5ac38406e8129e328d7a43820 rdf:first sg:person.0657017105.10
    120 rdf:rest N1554868eff6d4a39999d1036df7cb35f
    121 N1554868eff6d4a39999d1036df7cb35f rdf:first N26fbc964cf9c44ac8aead71e29c1d732
    122 rdf:rest Nf01c1e64cffc480596539632e5644c7f
    123 N1d9a2fd0c6774fde92c130b9ffbe5a65 rdf:first sg:person.0761337561.31
    124 rdf:rest Ncd4a3735431e43a89a8311769a3086a7
    125 N1fb7d3a63d1748bbaca946b86f68f35d schema:isbn 978-3-030-03142-8
    126 978-3-030-03143-5
    127 schema:name Sepsis Management in Resource-limited Settings
    128 rdf:type schema:Book
    129 N218776e11ebb42bcb299dd6d56217b50 rdf:first sg:person.01105040674.05
    130 rdf:rest N7d00766017ca4baa905fbe2ec4b85b14
    131 N26fbc964cf9c44ac8aead71e29c1d732 schema:affiliation grid-institutes:grid.48004.38
    132 schema:familyName Jacob
    133 schema:givenName Shevin T.
    134 rdf:type schema:Person
    135 N3845f1f85d7449b1bc8a1e1b24ecc6b7 schema:name Springer Nature - SN SciGraph project
    136 rdf:type schema:Organization
    137 N3de64fa308d145df95b793272b27bed9 rdf:first sg:person.0661420277.42
    138 rdf:rest Nfe17f09daa954b3aa2d1f09587263706
    139 N403d7f6284a8499eb218805230836a55 rdf:first sg:person.01322076671.14
    140 rdf:rest Neb3fb6f236ed4d058e6f4007c4e314fd
    141 N4092d30295c14e8493fad0995891df8b schema:name Springer Nature
    142 rdf:type schema:Organisation
    143 N4416b1279832483b9639a94b9e03ce6a rdf:first sg:person.0610604105.94
    144 rdf:rest N715a0c856c58480fa0e43948f32f9ec7
    145 N4dddc9e6b577454494773c6467f9b7df schema:name doi
    146 schema:value 10.1007/978-3-030-03143-5_1
    147 rdf:type schema:PropertyValue
    148 N4f27828868fb42f7a7c058a28c4ef687 schema:affiliation grid-institutes:grid.4714.6
    149 schema:familyName Baker
    150 schema:givenName Timothy
    151 rdf:type schema:Person
    152 N58a3e78e158f4a509250e51b8626836c rdf:first sg:person.01261070640.13
    153 rdf:rest N403d7f6284a8499eb218805230836a55
    154 N641c94104db14d209bc906a1fa8543a1 rdf:first sg:person.013716274643.40
    155 rdf:rest Nb600eed231a545518fd5b3a532bd6bc5
    156 N667d9906013f40fc854d389d5bc9d622 rdf:first sg:person.01345512332.33
    157 rdf:rest N641c94104db14d209bc906a1fa8543a1
    158 N6d282aa523cc4277823cc2d1d365233a schema:familyName Schultz
    159 schema:givenName Marcus J.
    160 rdf:type schema:Person
    161 N7068563d5f664c0a8af513fa5de59b40 rdf:first sg:person.013160470014.13
    162 rdf:rest Nfe7136a60efd48e9afd6e99602cdc263
    163 N715a0c856c58480fa0e43948f32f9ec7 rdf:first sg:person.0740103341.37
    164 rdf:rest N8ccb3266ea1c4ce99c81fa3a570cceb1
    165 N7ae652b45d974aaebc98070d35b9ade8 schema:familyName Dondorp
    166 schema:givenName Arjen M.
    167 rdf:type schema:Person
    168 N7d00766017ca4baa905fbe2ec4b85b14 rdf:first sg:person.0663401704.10
    169 rdf:rest rdf:nil
    170 N7d948c7c8af94d119715c74a2196b6ff rdf:first Nf359a003ebdb4b88938d1e318d4b2fd9
    171 rdf:rest Nf42d185c7e204493940cd5b55aa310e8
    172 N7e70fc27b3e745ea96a5fc5f1cb93f17 rdf:first N6d282aa523cc4277823cc2d1d365233a
    173 rdf:rest rdf:nil
    174 N8ccb3266ea1c4ce99c81fa3a570cceb1 rdf:first sg:person.0622142430.21
    175 rdf:rest N58a3e78e158f4a509250e51b8626836c
    176 N9895d9c55b9540f98076a42ddc0fce6e rdf:first sg:person.01055636325.74
    177 rdf:rest Nd0d830ae710d45728314a5f0366e0b77
    178 N9babfec902f64cdc974a3c45289b8a98 schema:affiliation grid-institutes:None
    179 schema:familyName Thien
    180 schema:givenName Binh Nguyen
    181 rdf:type schema:Person
    182 N9c205942fd4e44878a6dea2b991d033e rdf:first sg:person.010522476441.05
    183 rdf:rest N1d9a2fd0c6774fde92c130b9ffbe5a65
    184 Na31744fb3b0745a89e3461c7d7b54067 schema:familyName Dünser
    185 schema:givenName Martin W.
    186 rdf:type schema:Person
    187 Naeddc76a5b664fe8a350fcfbc7bc0928 rdf:first sg:person.01100610423.42
    188 rdf:rest Nc406c68173414f08874c896758ac8107
    189 Nb0053f19381143cfb0d2eb3e7b180f65 rdf:first Na31744fb3b0745a89e3461c7d7b54067
    190 rdf:rest N7e70fc27b3e745ea96a5fc5f1cb93f17
    191 Nb52c4e36ef0945519e62623f595e03f8 rdf:first sg:person.013052601043.07
    192 rdf:rest Ncea8e80842e64978a428e02303d19bdb
    193 Nb600eed231a545518fd5b3a532bd6bc5 rdf:first sg:person.01167550047.55
    194 rdf:rest N7d948c7c8af94d119715c74a2196b6ff
    195 Nbc9a7dac558242a9b6a5a6d9ffe8a1b5 rdf:first sg:person.013070162407.02
    196 rdf:rest Nd288e54e7d0c4f97a5c00a504154064d
    197 Nc19b0070f2a64ec99e82f561386de4a7 schema:affiliation grid-institutes:grid.412433.3
    198 schema:familyName Mai
    199 schema:givenName NT Hoang
    200 rdf:type schema:Person
    201 Nc406c68173414f08874c896758ac8107 rdf:first sg:person.0772543414.88
    202 rdf:rest Nc45096e024314701a7ecdfb4136e9a67
    203 Nc45096e024314701a7ecdfb4136e9a67 rdf:first sg:person.01343754225.51
    204 rdf:rest N9895d9c55b9540f98076a42ddc0fce6e
    205 Ncd4a3735431e43a89a8311769a3086a7 rdf:first sg:person.01146723623.29
    206 rdf:rest N144e85f5ac38406e8129e328d7a43820
    207 Ncea8e80842e64978a428e02303d19bdb rdf:first sg:person.01104732461.20
    208 rdf:rest N4416b1279832483b9639a94b9e03ce6a
    209 Nd0d830ae710d45728314a5f0366e0b77 rdf:first sg:person.0750363462.93
    210 rdf:rest N07350801643746f1ae1f6886e5610df6
    211 Nd288e54e7d0c4f97a5c00a504154064d rdf:first N4f27828868fb42f7a7c058a28c4ef687
    212 rdf:rest N9c205942fd4e44878a6dea2b991d033e
    213 Nd4b5c781c8744c989d9296c8d1a181a5 rdf:first sg:person.01075705652.42
    214 rdf:rest Nfa2e6584375942b098c47123eb59e66a
    215 Nd929de7b7f394f5cb80172b14c88aac9 rdf:first sg:person.01232635004.96
    216 rdf:rest N667d9906013f40fc854d389d5bc9d622
    217 Ndb6bab0cfb4549d5b859709ea9ee66b8 rdf:first sg:person.01007146366.19
    218 rdf:rest N3de64fa308d145df95b793272b27bed9
    219 Ne2ea654476f64dffbb692245f552f9da rdf:first sg:person.01051057723.31
    220 rdf:rest Nb52c4e36ef0945519e62623f595e03f8
    221 Neb3fb6f236ed4d058e6f4007c4e314fd rdf:first Nc19b0070f2a64ec99e82f561386de4a7
    222 rdf:rest N040481cb4dae493dabae84f44206a3ba
    223 Nf01c1e64cffc480596539632e5644c7f rdf:first sg:person.014150672735.74
    224 rdf:rest Nd4b5c781c8744c989d9296c8d1a181a5
    225 Nf359a003ebdb4b88938d1e318d4b2fd9 schema:affiliation grid-institutes:None
    226 schema:familyName Ranjit
    227 schema:givenName Suchitra
    228 rdf:type schema:Person
    229 Nf42d185c7e204493940cd5b55aa310e8 rdf:first sg:person.0600270775.23
    230 rdf:rest N218776e11ebb42bcb299dd6d56217b50
    231 Nf902624fbaf64b78a4926ffe1bb59437 rdf:first N7ae652b45d974aaebc98070d35b9ade8
    232 rdf:rest Nb0053f19381143cfb0d2eb3e7b180f65
    233 Nfa2e6584375942b098c47123eb59e66a rdf:first sg:person.01366266562.86
    234 rdf:rest Ne2ea654476f64dffbb692245f552f9da
    235 Nfe17f09daa954b3aa2d1f09587263706 rdf:first sg:person.01162317707.88
    236 rdf:rest N7068563d5f664c0a8af513fa5de59b40
    237 Nfe7136a60efd48e9afd6e99602cdc263 rdf:first sg:person.01362157550.77
    238 rdf:rest Naeddc76a5b664fe8a350fcfbc7bc0928
    239 Nffd4ffb4076645079af53dbc4f4d7580 schema:name dimensions_id
    240 schema:value pub.1112026912
    241 rdf:type schema:PropertyValue
    242 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    243 schema:name Medical and Health Sciences
    244 rdf:type schema:DefinedTerm
    245 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    246 schema:name Clinical Sciences
    247 rdf:type schema:DefinedTerm
    248 anzsrc-for:14 schema:inDefinedTermSet anzsrc-for:
    249 schema:name Economics
    250 rdf:type schema:DefinedTerm
    251 anzsrc-for:1402 schema:inDefinedTermSet anzsrc-for:
    252 schema:name Applied Economics
    253 rdf:type schema:DefinedTerm
    254 sg:person.01007146366.19 schema:affiliation grid-institutes:grid.7177.6
    255 schema:familyName Schultz
    256 schema:givenName Marcus J.
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007146366.19
    258 rdf:type schema:Person
    259 sg:person.01013154627.14 schema:affiliation grid-institutes:grid.21925.3d
    260 schema:familyName Angus
    261 schema:givenName Derek C.
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013154627.14
    263 rdf:type schema:Person
    264 sg:person.01051057723.31 schema:affiliation grid-institutes:grid.444534.6
    265 schema:familyName Lundeg
    266 schema:givenName Ganbold
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051057723.31
    268 rdf:type schema:Person
    269 sg:person.010522476441.05 schema:affiliation grid-institutes:grid.17866.3e
    270 schema:familyName Diaz
    271 schema:givenName Janet V.
    272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010522476441.05
    273 rdf:type schema:Person
    274 sg:person.01055636325.74 schema:affiliation grid-institutes:grid.7177.6
    275 schema:familyName Pisani
    276 schema:givenName Luigi
    277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055636325.74
    278 rdf:type schema:Person
    279 sg:person.01075705652.42 schema:affiliation grid-institutes:grid.413618.9
    280 schema:familyName Lodha
    281 schema:givenName Rakesh
    282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075705652.42
    283 rdf:type schema:Person
    284 sg:person.01100610423.42 schema:affiliation grid-institutes:grid.416252.6
    285 schema:familyName Kwizera
    286 schema:givenName Arthur
    287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100610423.42
    288 rdf:type schema:Person
    289 sg:person.01104732461.20 schema:affiliation grid-institutes:grid.414707.1
    290 schema:familyName Mer
    291 schema:givenName Mervyn
    292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104732461.20
    293 rdf:type schema:Person
    294 sg:person.01105040674.05 schema:affiliation grid-institutes:None
    295 schema:familyName Thevanayagam
    296 schema:givenName Jonarthan
    297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105040674.05
    298 rdf:type schema:Person
    299 sg:person.01146723623.29 schema:affiliation grid-institutes:grid.10223.32
    300 schema:familyName Haniffa
    301 schema:givenName Rashan
    302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146723623.29
    303 rdf:type schema:Person
    304 sg:person.01162317707.88 schema:affiliation grid-institutes:grid.7177.6
    305 schema:familyName Dondorp
    306 schema:givenName Arjen M.
    307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162317707.88
    308 rdf:type schema:Person
    309 sg:person.01167550047.55 schema:affiliation grid-institutes:None
    310 schema:familyName Povoa
    311 schema:givenName Pedro
    312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167550047.55
    313 rdf:type schema:Person
    314 sg:person.01232635004.96 schema:affiliation grid-institutes:grid.440315.7
    315 schema:familyName Pattnaik
    316 schema:givenName Rajyabardhan
    317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232635004.96
    318 rdf:type schema:Person
    319 sg:person.01261070640.13 schema:affiliation grid-institutes:grid.416252.6
    320 schema:familyName Nakibuuka
    321 schema:givenName Jane
    322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261070640.13
    323 rdf:type schema:Person
    324 sg:person.013052601043.07 schema:affiliation grid-institutes:grid.411192.e
    325 schema:familyName Misango
    326 schema:givenName David
    327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013052601043.07
    328 rdf:type schema:Person
    329 sg:person.013070162407.02 schema:affiliation grid-institutes:grid.413471.4
    330 schema:familyName Azevedo
    331 schema:givenName Luciano C.
    332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013070162407.02
    333 rdf:type schema:Person
    334 sg:person.013160470014.13 schema:affiliation grid-institutes:grid.17063.33
    335 schema:familyName Adhikari
    336 schema:givenName Neill K. J.
    337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013160470014.13
    338 rdf:type schema:Person
    339 sg:person.01322076671.14 schema:affiliation grid-institutes:grid.413562.7
    340 schema:familyName Neto
    341 schema:givenName Ary Serpa
    342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322076671.14
    343 rdf:type schema:Person
    344 sg:person.01343754225.51 schema:affiliation grid-institutes:grid.427669.8
    345 schema:familyName Papali
    346 schema:givenName Alfred
    347 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343754225.51
    348 rdf:type schema:Person
    349 sg:person.01345512332.33 schema:affiliation grid-institutes:grid.412106.0
    350 schema:familyName Phua
    351 schema:givenName Jason
    352 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345512332.33
    353 rdf:type schema:Person
    354 sg:person.01362157550.77 schema:affiliation grid-institutes:grid.411681.b
    355 schema:familyName Iyer
    356 schema:givenName Shivakumar
    357 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362157550.77
    358 rdf:type schema:Person
    359 sg:person.01366266562.86 schema:affiliation grid-institutes:None
    360 schema:familyName Martin-Loeches
    361 schema:givenName Ignacio
    362 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366266562.86
    363 rdf:type schema:Person
    364 sg:person.013716274643.40 schema:affiliation grid-institutes:grid.120073.7
    365 schema:familyName Preller
    366 schema:givenName Jacobus
    367 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013716274643.40
    368 rdf:type schema:Person
    369 sg:person.014150672735.74 schema:affiliation grid-institutes:grid.414137.4
    370 schema:familyName Kissoon
    371 schema:givenName Niranjan
    372 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014150672735.74
    373 rdf:type schema:Person
    374 sg:person.0600270775.23 schema:affiliation grid-institutes:grid.38142.3c
    375 schema:familyName Talmor
    376 schema:givenName Daniel
    377 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600270775.23
    378 rdf:type schema:Person
    379 sg:person.0610604105.94 schema:affiliation grid-institutes:grid.440315.7
    380 schema:familyName Mohanty
    381 schema:givenName Sanjib
    382 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610604105.94
    383 rdf:type schema:Person
    384 sg:person.0622142430.21 schema:affiliation grid-institutes:grid.34477.33
    385 schema:familyName Musa
    386 schema:givenName Ndidiamaka
    387 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622142430.21
    388 rdf:type schema:Person
    389 sg:person.0657017105.10 schema:affiliation grid-institutes:grid.412695.d
    390 schema:familyName Jawa
    391 schema:givenName Randeep
    392 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657017105.10
    393 rdf:type schema:Person
    394 sg:person.0661420277.42 schema:affiliation grid-institutes:grid.9970.7
    395 schema:familyName Dünser
    396 schema:givenName Martin W.
    397 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661420277.42
    398 rdf:type schema:Person
    399 sg:person.0663401704.10 schema:affiliation grid-institutes:grid.4991.5
    400 schema:familyName Thwaites
    401 schema:givenName C. Louise
    402 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663401704.10
    403 rdf:type schema:Person
    404 sg:person.0740103341.37 schema:affiliation grid-institutes:grid.414137.4
    405 schema:familyName Murthy
    406 schema:givenName Srinivas
    407 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740103341.37
    408 rdf:type schema:Person
    409 sg:person.0750363462.93 schema:affiliation grid-institutes:grid.38142.3c
    410 schema:familyName Riviello
    411 schema:givenName Elisabeth D.
    412 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750363462.93
    413 rdf:type schema:Person
    414 sg:person.0761337561.31 schema:affiliation grid-institutes:grid.417467.7
    415 schema:familyName Festic
    416 schema:givenName Emir
    417 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761337561.31
    418 rdf:type schema:Person
    419 sg:person.0772543414.88 schema:affiliation grid-institutes:grid.7177.6
    420 schema:familyName Lubell
    421 schema:givenName Yoel
    422 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772543414.88
    423 rdf:type schema:Person
    424 grid-institutes:None schema:alternateName Appolo Hospitals, Chennai, India
    425 Hospital de Sao Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal
    426 Mzuzu Central Hospital, Mzuzu, Malawi
    427 St. James’s University Hospital, Dublin, Ireland
    428 Trung Vuong Hospital, Ho Chi Minh City, Vietnam
    429 schema:name Appolo Hospitals, Chennai, India
    430 Hospital de Sao Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal
    431 Mzuzu Central Hospital, Mzuzu, Malawi
    432 Nova Medical School, CEDOC, New University of Lisbon, Lisbon, Portugal
    433 St. James’s University Hospital, Dublin, Ireland
    434 Trung Vuong Hospital, Ho Chi Minh City, Vietnam
    435 rdf:type schema:Organization
    436 grid-institutes:grid.10223.32 schema:alternateName Mahidol University, Bangkok, Thailand
    437 schema:name Mahidol University, Bangkok, Thailand
    438 rdf:type schema:Organization
    439 grid-institutes:grid.120073.7 schema:alternateName Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    440 schema:name Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    441 rdf:type schema:Organization
    442 grid-institutes:grid.17063.33 schema:alternateName Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
    443 schema:name Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
    444 rdf:type schema:Organization
    445 grid-institutes:grid.17866.3e schema:alternateName California Pacific Medical Center, San Francisco, CA, USA
    446 schema:name California Pacific Medical Center, San Francisco, CA, USA
    447 rdf:type schema:Organization
    448 grid-institutes:grid.21925.3d schema:alternateName University of Pittsburgh, Pittsburgh, PA, USA
    449 schema:name University of Pittsburgh, Pittsburgh, PA, USA
    450 rdf:type schema:Organization
    451 grid-institutes:grid.34477.33 schema:alternateName Seattle Children’s Hospital, University of Washington, Washington, WA, USA
    452 schema:name Seattle Children’s Hospital, University of Washington, Washington, WA, USA
    453 rdf:type schema:Organization
    454 grid-institutes:grid.38142.3c schema:alternateName Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    455 schema:name Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    456 rdf:type schema:Organization
    457 grid-institutes:grid.411192.e schema:alternateName Aga Khan University Hospital, Nairobi, Kenya
    458 schema:name Aga Khan University Hospital, Nairobi, Kenya
    459 rdf:type schema:Organization
    460 grid-institutes:grid.411681.b schema:alternateName Bharati Vidyapeeth Deemed University Medical College, Pune, India
    461 schema:name Bharati Vidyapeeth Deemed University Medical College, Pune, India
    462 rdf:type schema:Organization
    463 grid-institutes:grid.412106.0 schema:alternateName National University Hospital, Singapore, Singapore
    464 schema:name National University Hospital, Singapore, Singapore
    465 rdf:type schema:Organization
    466 grid-institutes:grid.412433.3 schema:alternateName Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    467 schema:name Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    468 rdf:type schema:Organization
    469 grid-institutes:grid.412695.d schema:alternateName Stony Brook University Medical Center, Stony Brook, NY, USA
    470 schema:name Stony Brook University Medical Center, Stony Brook, NY, USA
    471 rdf:type schema:Organization
    472 grid-institutes:grid.413471.4 schema:alternateName Hospital Sirio-Libanes, Saõ Paulo, Brazil
    473 schema:name Hospital Sirio-Libanes, Saõ Paulo, Brazil
    474 rdf:type schema:Organization
    475 grid-institutes:grid.413562.7 schema:alternateName Medical Intensive Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
    476 schema:name Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    477 Medical Intensive Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
    478 rdf:type schema:Organization
    479 grid-institutes:grid.413618.9 schema:alternateName All India Institute of Medical Science, Delhi, India
    480 schema:name All India Institute of Medical Science, Delhi, India
    481 rdf:type schema:Organization
    482 grid-institutes:grid.414137.4 schema:alternateName British Columbia Children’s Hospital, Vancouver, BC, Canada
    483 schema:name British Columbia Children’s Hospital, Vancouver, BC, Canada
    484 rdf:type schema:Organization
    485 grid-institutes:grid.414707.1 schema:alternateName Johannesburg Hospital, University of the Witwatersrand, Johannesburg, South Africa
    486 schema:name Johannesburg Hospital, University of the Witwatersrand, Johannesburg, South Africa
    487 rdf:type schema:Organization
    488 grid-institutes:grid.416252.6 schema:alternateName Mulago National Referral Hospital, Kampala, Uganda
    489 schema:name Mulago National Referral Hospital, Kampala, Uganda
    490 rdf:type schema:Organization
    491 grid-institutes:grid.417467.7 schema:alternateName Mayo Clinic, Jacksonville, FL, USA
    492 schema:name Mayo Clinic, Jacksonville, FL, USA
    493 rdf:type schema:Organization
    494 grid-institutes:grid.427669.8 schema:alternateName Division of Pulmonary and Critical Care Medicine, Atrium Health, Charlotte, NC, USA
    495 schema:name Division of Pulmonary and Critical Care Medicine, Atrium Health, Charlotte, NC, USA
    496 University of Maryland School of Medicine, Baltimore, MD, USA
    497 rdf:type schema:Organization
    498 grid-institutes:grid.440315.7 schema:alternateName Ispat General Hospital, Rourkela, Odisha, India
    499 schema:name Ispat General Hospital, Rourkela, Odisha, India
    500 rdf:type schema:Organization
    501 grid-institutes:grid.444534.6 schema:alternateName Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia
    502 schema:name Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia
    503 rdf:type schema:Organization
    504 grid-institutes:grid.4714.6 schema:alternateName Karolinska Institute, Stockholm, Sweden
    505 schema:name Karolinska Institute, Stockholm, Sweden
    506 rdf:type schema:Organization
    507 grid-institutes:grid.48004.38 schema:alternateName Liverpool School of Tropical Medicine, Liverpool, UK
    508 schema:name Liverpool School of Tropical Medicine, Liverpool, UK
    509 rdf:type schema:Organization
    510 grid-institutes:grid.4991.5 schema:alternateName Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK
    511 schema:name Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK
    512 rdf:type schema:Organization
    513 grid-institutes:grid.7177.6 schema:alternateName Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    514 schema:name Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    515 Mahidol University, Bangkok, Thailand
    516 rdf:type schema:Organization
    517 grid-institutes:grid.9970.7 schema:alternateName Kepler University Hospital, Johannes Kepler University, Linz, Austria
    518 schema:name Kepler University Hospital, Johannes Kepler University, Linz, Austria
    519 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...