Primary chemotherapy in malignant fibrous histiocytoma of bone — Updated UTMD Anderson Cancer Center Experience View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1994

AUTHORS

S. R. Patel , T. Armen , C. H. Carrasco , A. K. Raymond , A. G. Ayala , J. A. Murray , S. P. Chawla , R. S. Benjamin

ABSTRACT

Malignant Fibrous Histiocytoma (MFH) of bone is a relatively recently recognized entity. After the initial reports in the early 70 s [1], this entity became well established in the pathology and clinical literature by the late 70 s [2–4]. The age distribution is variable, patients are generally older than those with osteosarcoma, and there seems to be a slight predilection for males [5]. The skeletal distribution is also variable, with a predilection for the metaphyses of long bones [6]. Radiologically, it manifests as an aggressive radiolucent defect with ill-defined margins and often, an associated soft-tissue mass. Histologically, it shows striking resemblance to MFH arising in soft tissues. Not infrequently, it constitutes the high grade component of a de-differentiated chondrosarcoma, which has a relatively poorer prognosis. It often is a component of osteosarcomas, and histologically, the only major difference between a fibroblastic osteosarcoma and an MFH is the presence or absence of osteoid. In our experience at the UT MD Anderson Cancer Center, we have seen 2 patients, 1 of them reported in this series, where the initial biopsy and the final surgical specimen diagnosis was felt to be an MFH, but the metastatic disease that developed at a later date unequivocally demonstrated osteoid, making us hypothesise, that MFH of bone may indeed be a variant of fibroblastic osteosarcoma with no demonstrable osteoid initially, however it can manifest at a later date. More... »

PAGES

577-580

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-2-8178-0765-2_123

DOI

http://dx.doi.org/10.1007/978-2-8178-0765-2_123

DIMENSIONS

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