Sphingosine-1-Phosphate in Hypoxic Signaling View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2014

AUTHORS

Olivier Cuvillier

ABSTRACT

Hypoxia is a characteristic of solid tumors, and the adaptation of cancer cells to hypoxia is instrumental in the development of aggressive phenotype. In most clinical studies, endogenous markers of hypoxia show prognostic significance for patient outcome. At the cellular level, the adaptation to hypoxia is predominantly mediated by the hypoxia-inducible factors (HIFs) that regulate the expression of a broad range of target genes promoting angiogenesis, glycolysis, metastasis, increased tumor growth, and resistance to treatments. Sphingosine 1-phosphate is a lipid mediator regulating numerous cellular activities including proliferation, survival, migration, inflammation, or angiogenesis. Recent studies have highlighted the potential role of sphingosine 1-phosphate in hypoxia. In this review, we will discuss the role of sphingosine 1-phosphate metabolism with regard to hypoxia signaling and the potential use of sphingosine 1-phosphate-based therapeutic strategies in cancer therapy. More... »

PAGES

199-217

References to SciGraph publications

  • 2010-11. Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2007-06. Hypoxia in cancer: significance and impact on clinical outcome in CANCER AND METASTASIS REVIEWS
  • 2006-09. Role of tumor-associated macrophages in tumor progression and invasion in CANCER AND METASTASIS REVIEWS
  • 2012-07. Overcoming disappointing results with antiangiogenic therapy by targeting hypoxia in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2007-06. Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment in CANCER AND METASTASIS REVIEWS
  • 2006. Mitochondrial Reactive Oxygen Species are Required for Hypoxic HIFα Stabilization in HYPOXIA AND EXERCISE
  • 2006-01. Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting shingosine kinase-1 in LEUKEMIA
  • 2010-08. Role of hypoxia-inducible transcription factor 1α for progression and chemosensitivity of murine hepatocellular carcinoma in JOURNAL OF MOLECULAR MEDICINE
  • 2011-12. Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2007-06. Hypoxia: A key regulator of angiogenesis in cancer in CANCER AND METASTASIS REVIEWS
  • 2011-01. G protein-coupled receptors: novel targets for drug discovery in cancer in NATURE REVIEWS DRUG DISCOVERY
  • 2011-06. Targeting hypoxia in cancer therapy in NATURE REVIEWS CANCER
  • 1996-06. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate in NATURE
  • 2010-06. Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2 in NATURE
  • 2010-02. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics in ONCOGENE
  • 2000-07. Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein in NATURE CELL BIOLOGY
  • 2012-02. Modulation of hypoxia-inducible factors (HIF) from an integrative pharmacological perspective in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2007-06. Hypoxia-driven selection of the metastatic phenotype in CANCER AND METASTASIS REVIEWS
  • 2013. Tumor Oxygenation: An Appraisal of Past and Present Concepts and a Look into the Future in OXYGEN TRANSPORT TO TISSUE XXXV
  • 2007-12. Sphingosine kinase-1 mediates BCR/ABL-induced upregulation of Mcl-1 in chronic myeloid leukemia cells in ONCOGENE
  • 2002-01. Hypoxia — a key regulatory factor in tumour growth in NATURE REVIEWS CANCER
  • 2002-01. Multidrug resistance in cancer: role of ATP–dependent transporters in NATURE REVIEWS CANCER
  • 2008-05. Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells in LEUKEMIA
  • 2011-12. Extracellular and intracellular sphingosine-1-phosphate in cancer in CANCER AND METASTASIS REVIEWS
  • 2010-08-03. Hypoxic Tumors and Their Effect on Immune Cells and Cancer Therapy in IMMUNOTHERAPY OF CANCER
  • 2010-07. Sphingosine 1-phosphate and cancer in NATURE REVIEWS CANCER
  • 2008-03. Hypoxia and metabolism: Hypoxia, DNA repair and genetic instability in NATURE REVIEWS CANCER
  • 2008-04. Mitochondrial complex III regulates hypoxic activation of HIF in CELL DEATH & DIFFERENTIATION
  • 2010. Extracellular and Intracellular Actions of Sphingosine-1-Phosphate in SPHINGOLIPIDS AS SIGNALING AND REGULATORY MOLECULES
  • 2009-05. Effect of Hypoxia-inducible Factor-1α Silencing on the Sensitivity of Human Brain Glioma Cells to Doxorubicin and Etoposide in NEUROCHEMICAL RESEARCH
  • Book

    TITLE

    Molecular Mechanisms of Angiogenesis

    ISBN

    978-2-8178-0465-1
    978-2-8178-0466-8

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-2-8178-0466-8_9

    DOI

    http://dx.doi.org/10.1007/978-2-8178-0466-8_9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036593351


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