Role of Endothelial Cells in Tumor Escape from Immunity View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2014

AUTHORS

Fabrice Soncin

ABSTRACT

Blood vessel endothelial cells directly participate in the development of solid tumors. Endothelial cells are the main actors of sprouting angiogenesis, the process by which the host organism provides blood vessels to the tumors. Once the vessels are in place, they form a physical barrier which protects tumor cells from the host immune cells and from treatments. There are several ways by which tumors tune their endothelial cells to mediate such escape: expression of leukocyte adhesion receptors by tumor endothelial cells is reduced, preventing the capture of immune cells from the blood circulation. Endothelial cell anergy represses the responses of tumor blood vessels to inflammatory cytokines. Furthermore, endothelial cells naturally produce endogenous repressors of their activation which, in a tumor context, help escaping immune destruction. Several strategies aimed at targeting tumor blood vessels actually promote endothelial cell activation and look promising for treating cancers. More... »

PAGES

325-337

Book

TITLE

Molecular Mechanisms of Angiogenesis

ISBN

978-2-8178-0465-1
978-2-8178-0466-8

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-2-8178-0466-8_15

DOI

http://dx.doi.org/10.1007/978-2-8178-0466-8_15

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018855157


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