Epidemiology of Pancreatic Neuroendocrine Tumours View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2004

AUTHORS

Helen Doran , John P. Neoptolemos , Evelyn M. I. Williams , Robert Sutton

ABSTRACT

Pancreatic neuroendocrine tumours are rare neoplastic growths of endocrine pancreatic tissue with both neural and endocrine features, frequently causing clinical syndromes from uncontrolled hormone secretion.1,2 Those tumours that cause such syndromes have been classified as‘functional’ whilst those without obvious hypersecretion have been classified as‘non-gunctional’.1–3 However,‘nonfunctional’ tumours secrete various peptides and proteins, including chromogranins, plasma levels of which can be used as tumour markers.1,3,4 There are a number of well recognised syndromic tumours, the commonest being insulinoma and gastrinoma, although many gastrinomas arise in the duodenum (see Table 1.1). A minority of patients presenting with pancreatic neuroendocrine tumours have one of four inherited disorders producing tumours at many sites: multiple endocrine neoplasia type 1 (MEN-1)5, von Hippel-Lindau disease6 (see Ch. 12), neurofibromatosis7 and tuberous sclerosis.8 More... »

PAGES

5-17

Book

TITLE

Pancreatic Disease

ISBN

978-1-4471-3491-6
978-1-85233-904-3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-85233-904-3_1

DOI

http://dx.doi.org/10.1007/978-1-85233-904-3_1

DIMENSIONS

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