Psoriasis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2008

AUTHORS

Frank O. Nestle

ABSTRACT

Psoriasis is a common, immune-mediated inflammatory papulosquamous skin disease that results in recurring scaly, erythematous plaques, typically in a symmetrical distribution.There is strong evidence that psoriasis is determined by genetic predisposition. It is thought that there is not a single disease gene, but rather a complex set of gene variants that results in an abnormal response to environmental factors.Psoriasis is now considered to be a disease caused by the infiltration of effector immunocytes in the epidermis and dermis.Important effector cells are CD4 and CD8 conventional T-lymphocytes, as well as natural killer (NK) T cells, plasmacytoid dendritic cells (PDCs), TIP-DCs.Other cell types that participate in this pathologic process include keratinocytes, endothelial cells, fibroblasts, monocytes/macrophages, and neutrophils.Pathologic cytokines include inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-α (IFN-α), T-helper-1 (Th1) cytokines such as IFN-γ, Th17 cytokines such as interleukin-17 (IL-17) and IL-22, and antigenpresenting cell (APC)-derived cytokines such as IL-12 and IL-23.Biologic agents have emerged as effective treatments for psoriasis. They include anti-T-cell agents (efalizumab and alefecept), and anti-TNF-α agents (etanercept, infliximab, and adalimumab). Psoriasis is a common, immune-mediated inflammatory papulosquamous skin disease that results in recurring scaly, erythematous plaques, typically in a symmetrical distribution. There is strong evidence that psoriasis is determined by genetic predisposition. It is thought that there is not a single disease gene, but rather a complex set of gene variants that results in an abnormal response to environmental factors. Psoriasis is now considered to be a disease caused by the infiltration of effector immunocytes in the epidermis and dermis. Important effector cells are CD4 and CD8 conventional T-lymphocytes, as well as natural killer (NK) T cells, plasmacytoid dendritic cells (PDCs), TIP-DCs. Other cell types that participate in this pathologic process include keratinocytes, endothelial cells, fibroblasts, monocytes/macrophages, and neutrophils. Pathologic cytokines include inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-α (IFN-α), T-helper-1 (Th1) cytokines such as IFN-γ, Th17 cytokines such as interleukin-17 (IL-17) and IL-22, and antigenpresenting cell (APC)-derived cytokines such as IL-12 and IL-23. Biologic agents have emerged as effective treatments for psoriasis. They include anti-T-cell agents (efalizumab and alefecept), and anti-TNF-α agents (etanercept, infliximab, and adalimumab). More... »

PAGES

207-216

References to SciGraph publications

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  • Book

    TITLE

    Clinical and Basic Immunodermatology

    ISBN

    978-1-84800-164-0
    978-1-84800-165-7

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-84800-165-7_14

    DOI

    http://dx.doi.org/10.1007/978-1-84800-165-7_14

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052457077


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