Kidney in Acute Heart Failure View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2008

AUTHORS

Guido Boerrigter , Fernando L. Martin , John C. Burnett

ABSTRACT

The hallmark of symptomatic heart failure (HF) is sodium and water retention, leading to congestion and symptoms of edema. Indeed, Starling in the 19th century asked provocatively, “What, if anything, does the heart have to do with heart failure?” He also advanced the theory that “humors” must be released in HF that lead to leakiness of capillaries and edema formation, a concept that is not opposed to our current understanding of the complex activation of diverse neurohumoral systems that characterize symptomatic HF and contribute to renal dysfunction. Key epidemiologic studies have refocused our attention on the role of the kidney in this syndrome, as they have established that renal dysfunction is one of the most robust predictors of mortality and morbidity in the setting of ventricular dysfunction and HF. Specifically, in two retrospective analyses, impaired renal function was identified as a major predictor of mortality in human HF, more powerful even than New York Heart Association (NYHA) class or left ventricular ejection fraction.1,2 More... »

PAGES

751-762

Book

TITLE

Acute Heart Failure

ISBN

978-1-84628-781-7
978-1-84628-782-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-84628-782-4_68

DOI

http://dx.doi.org/10.1007/978-1-84628-782-4_68

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014058159


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