Growth Characteristics of Organisms View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2007

AUTHORS

Robert A. Gatenby , B. Roy Frieden

ABSTRACT

In this chapter a systems viewpoint is taken of the growth characteristics of normal and malignant tissue. We find that such growth is well analyzed by the concepts of Shannon and Fisher information. In Section 3.1 conventional mechanisms of information transmission via DNA, RNA, and proteins are identified, as well as unconventional structures such as lipids and ion gradients. Information storage, flow, and utilization are analyzed, both within cells and over a system of cells. In Section 3.2, malignant tissue growth is found to be accurately described by the use of Fisher information in particular. Cancer growth is seen to occur as a disease of information, in fact an information catastrophe due to the regression of cells to a minimally ordered state consistent with life. The analysis yields many predictions about the growth of healthy tissue and cancerous tissue, some of which are nonintuitive and have a strong bearing on cancer diagnosis and treatment. More... »

PAGES

74-118

References to SciGraph publications

Book

TITLE

Exploratory Data Analysis Using Fisher Information

ISBN

978-1-84628-506-6
978-1-84628-777-0

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-84628-777-0_3

DOI

http://dx.doi.org/10.1007/978-1-84628-777-0_3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018726977


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