In Vitro Selection of Allosteric Ribozymes that Sense the Bacterial Second Messenger c-di-GMP View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2014

AUTHORS

Kazuhiro Furukawa , Hongzhou Gu , Ronald R. Breaker

ABSTRACT

Recently, a number of study have shown the ligand-dependent allosteric ribozymes can be harnessed as biosensors, high-throughput screening, and agents for the control of gene expression in vivo, called artificial riboswitches. In this chapter, we describe how in vitro selection can be used to create an allosteric ribozyme that senses bacterial second messenger cyclic-di-GMP (c-di-GMP). A hammerhead ribozyme was joined to a natural c-di-GMP class I riboswitch aptamer via communication modules. Both c-di-GMP-activating and -inhibiting ribozyme can be obtained by this approach. More... »

PAGES

209-20

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-62703-755-6_15

DOI

http://dx.doi.org/10.1007/978-1-62703-755-6_15

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020646066

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24549622


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