Ontology type: schema:Chapter
2014
AUTHORSRagini Kudchadkar , Geoffrey Gibney , Vernon K. Sondak
ABSTRACTPersonalized melanoma medicine has progressed from histopathologic features to serum markers to molecular profiles. Since the identification of activating BRAF mutations and subsequent development of drugs targeting the mutant BRAF protein, oncologists now need to incorporate prognostic and predictive biomarkers into treatment decisions for their melanoma patients. Examples include subgrouping patients by genotype profiles for targeted therapy and the development of serologic, immunohistochemical, and genotype profiles for the selection of patients for immunotherapies. In this chapter, we provide an overview of the current status of BRAF mutation testing, as well as promising serologic and molecular profiles that will impact patient care. As further research helps clarify the roles of these factors, the clinical outcomes of melanoma patients promise to be greatly improved. More... »
PAGES27-42
Molecular Diagnostics for Melanoma
ISBN
978-1-62703-726-6
978-1-62703-727-3
http://scigraph.springernature.com/pub.10.1007/978-1-62703-727-3_3
DOIhttp://dx.doi.org/10.1007/978-1-62703-727-3_3
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1046800658
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/24258972
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biomarkers, Tumor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunotherapy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Melanoma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Molecular Targeted Therapy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Metastasis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Skin Neoplasms",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Moffitt Cancer Center",
"id": "https://www.grid.ac/institutes/grid.468198.a",
"name": [
"Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL, USA"
],
"type": "Organization"
},
"familyName": "Kudchadkar",
"givenName": "Ragini",
"id": "sg:person.01001716007.11",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001716007.11"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Moffitt Cancer Center",
"id": "https://www.grid.ac/institutes/grid.468198.a",
"name": [
"Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL, USA"
],
"type": "Organization"
},
"familyName": "Gibney",
"givenName": "Geoffrey",
"id": "sg:person.01065153434.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065153434.51"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Moffitt Cancer Center",
"id": "https://www.grid.ac/institutes/grid.468198.a",
"name": [
"Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL, USA"
],
"type": "Organization"
},
"familyName": "Sondak",
"givenName": "Vernon K.",
"id": "sg:person.0725307737.77",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725307737.77"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1309/wbf7-n8kh-71kt-rvq9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000115620"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/pas.0b013e31826485c0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000883458"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/pas.0b013e31826485c0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000883458"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cll.2011.03.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001133573"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(12)70431-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001236716"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/cmr.0b013e3283550aa5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001379869"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/cmr.0b013e3283550aa5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001379869"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2013.51.4802",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002061814"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa060992",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003015127"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(12)60868-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003772891"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0047054",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003881342"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2133.2010.10185.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004824673"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ajpath.2011.03.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006558935"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ajpath.2011.03.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006558935"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa050092",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007050226"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa050092",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007050226"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.5858/arpa.2011-0673-oa",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007130144"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.11196",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007330825"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/elps.200800456",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007449081"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/s10434-012-2457-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007858751",
"https://doi.org/10.1245/s10434-012-2457-5"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ophtha.2012.02.017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007940456"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.5858/arpa.2011-0505-oa",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010164242"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/jid.2011.464",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010210944",
"https://doi.org/10.1038/jid.2011.464"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/jid.2011.464",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010210944"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-07-4068",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011456748"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/ppo.0b013e31824ba4df",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012437568"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/ppo.0b013e31824ba4df",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012437568"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/cji.0b013e31826e8f5f",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012791581"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/cji.0b013e31826e8f5f",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012791581"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2007.14.0707",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013453815"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejca.2011.09.028",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013661007"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-13-2007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013918808"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0035295",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014478292"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0035295",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014478292"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/pdm.0b013e31823b216f",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014577921"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/pdm.0b013e31823b216f",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014577921"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/pas.0b013e31815b8288",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015189145"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/pas.0b013e31815b8288",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015189145"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature07586",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018711414",
"https://doi.org/10.1038/nature07586"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.humpath.2011.10.022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019342301"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2011.41.3799",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019942987"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejca.2012.09.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020056704"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00401-011-0841-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020149937",
"https://doi.org/10.1007/s00401-011-0841-z"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2004.07.112",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022053177"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/cco.0b013e3283436e79",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022666107"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/cco.0b013e3283436e79",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022666107"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/aso.2004.03.044",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022869109",
"https://doi.org/10.1245/aso.2004.03.044"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/aso.2004.03.044",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022869109",
"https://doi.org/10.1245/aso.2004.03.044"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/srep00765",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023060679",
"https://doi.org/10.1038/srep00765"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/onc.2010.323",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023434167",
"https://doi.org/10.1038/onc.2010.323"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/onc.2010.323",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023434167",
"https://doi.org/10.1038/onc.2010.323"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature00766",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023536940",
"https://doi.org/10.1038/nature00766"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature00766",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023536940",
"https://doi.org/10.1038/nature00766"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6605635",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024092309",
"https://doi.org/10.1038/sj.bjc.6605635"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000658-197011000-00017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024444875"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000658-197011000-00017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024444875"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-12-0052",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025268968"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.74.12.5463",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025360556"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2010.32.4327",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027360666"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archsurg.1992.01420040034005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027788056"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/jama.2011.746",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028680620"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1000584",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028808360"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/dad.0b013e3181cf7cc1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030654869"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/dad.0b013e3181cf7cc1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030654869"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/dad.0b013e3181cf7cc1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030654869"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-10-3169",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031380951"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2353/jmoldx.2007.060191",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031783067"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2012.47.7836",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031794892"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.26724",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031953930"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2008.21.1540",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032602654"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2217/1750743x.1.1.19",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033418604"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000658-197812000-00004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033822542"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000658-197812000-00004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033822542"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(08)61033-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034187112"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/pcmr.12153",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034457567"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-11-0116",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034962577"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1097-0142(19960401)77:7<1303::aid-cncr12>3.0.co;2-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036127185"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.28306",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037251786"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/cmr.0b013e32833d8d48",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037408950"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/cmr.0b013e32833d8d48",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037408950"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2010.33.9275",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038427267"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm0902-1039c",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038547603",
"https://doi.org/10.1038/nm0902-1039c"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm0902-1039c",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038547603",
"https://doi.org/10.1038/nm0902-1039c"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00262-012-1227-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039718387",
"https://doi.org/10.1007/s00262-012-1227-3"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.25747",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039878710"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.192461099",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039946320"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2013.50.3144",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040788147"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1103782",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041864150"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11894-010-0161-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042166448",
"https://doi.org/10.1007/s11894-010-0161-9"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2011.41.2452",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042272002"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1305133",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042841008"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1200690",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042896583"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.910",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043671664",
"https://doi.org/10.1038/ng.910"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.910",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043671664",
"https://doi.org/10.1038/ng.910"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1200694",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047413837"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/cji.0b013e3182372636",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048247637"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/cji.0b013e3182372636",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048247637"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/dad.0b013e31823135a3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049859076"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/dad.0b013e31823135a3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049859076"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/jmedgenet-2011-100156",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051723503"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/jmedgenet-2011-100156",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051723503"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2013.50.4662",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051759381"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1203421",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051983710"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1003466",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052212829"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2010.31.5812",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053274058"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/pas.0b013e318246b527",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060343604"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/pas.0b013e318246b527",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060343604"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/pas.0b013e318246b527",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060343604"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/pas.0b013e318246b527",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060343604"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/pas.0b013e318246b527",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060343604"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.14670/hh-25.1139",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1078184970"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078192830",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1043/2009-0612-rar.1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1078310820"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081334499",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.1998.16.9.2921",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083316810"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2013.31.18_suppl.cra9003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083394087"
],
"type": "CreativeWork"
}
],
"datePublished": "2014",
"datePublishedReg": "2014-01-01",
"description": "Personalized melanoma medicine has progressed from histopathologic features to serum markers to molecular profiles. Since the identification of activating BRAF mutations and subsequent development of drugs targeting the mutant BRAF protein, oncologists now need to incorporate prognostic and predictive biomarkers into treatment decisions for their melanoma patients. Examples include subgrouping patients by genotype profiles for targeted therapy and the development of serologic, immunohistochemical, and genotype profiles for the selection of patients for immunotherapies. In this chapter, we provide an overview of the current status of BRAF mutation testing, as well as promising serologic and molecular profiles that will impact patient care. As further research helps clarify the roles of these factors, the clinical outcomes of melanoma patients promise to be greatly improved.",
"editor": [
{
"familyName": "Thurin",
"givenName": "Magdalena",
"type": "Person"
},
{
"familyName": "Marincola",
"givenName": "Francesco M.",
"type": "Person"
}
],
"genre": "chapter",
"id": "sg:pub.10.1007/978-1-62703-727-3_3",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": {
"isbn": [
"978-1-62703-726-6",
"978-1-62703-727-3"
],
"name": "Molecular Diagnostics for Melanoma",
"type": "Book"
},
"name": "Integrating Molecular Biomarkers into Current Clinical Management in Melanoma",
"pagination": "27-42",
"productId": [
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/978-1-62703-727-3_3"
]
},
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"def0aada6903f9d0fb9bdaffdf81bfb329b2e42b625e69c11e900aac56bd69f0"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1046800658"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"24258972"
]
}
],
"publisher": {
"location": "Totowa, NJ",
"name": "Humana Press",
"type": "Organisation"
},
"sameAs": [
"https://doi.org/10.1007/978-1-62703-727-3_3",
"https://app.dimensions.ai/details/publication/pub.1046800658"
],
"sdDataset": "chapters",
"sdDatePublished": "2019-04-15T17:16",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000272.jsonl",
"type": "Chapter",
"url": "http://link.springer.com/10.1007/978-1-62703-727-3_3"
}
]Download the RDF metadata as:Â json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-62703-727-3_3'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-62703-727-3_3'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-62703-727-3_3'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-62703-727-3_3'
This table displays all metadata directly associated to this object as RDF triples.
394 TRIPLES
23 PREDICATES
124 URIs
28 LITERALS
16 BLANK NODES