Paracrine Communication Between Mechanically Stretched Myocytes and Fibroblasts View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2013

AUTHORS

Hao Feng , Fnu Gerilechaogetu , Honey B. Golden , Damir Nizamutdinov , Donald M. Foster , Shannon Glaser , David E. Dostal

ABSTRACT

Mechanical stretch is a major factor for myocardial hypertrophy and heart failure. Stretch activates mechanical sensors from cardiac myocytes, leading to a series of signal transduction cascades, which can result in cell malfunction and remodeling. It is well known that mechanical stretch also induces the release of paracrine factors from cardiac fibroblasts, as well as myocytes. Due to complicated circumstance of heart tissue, it is difficult to fully investigate the characteristics of these factors in situ. Here we describe static stretch and conditioned medium experiments as methods to examine the function of paracrine factors between primary cultured cardiac myocytes and fibroblasts. More... »

PAGES

57-66

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-62703-604-7_5

DOI

http://dx.doi.org/10.1007/978-1-62703-604-7_5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044201286

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23955733


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