Synthesis, Characterization, and Evaluation of Radiometal-Containing Peptide Nucleic Acids View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2014

AUTHORS

Holger Stephan , Christian Foerster , Gilles Gasser

ABSTRACT

Peptide nucleic acids (PNAs) have very attractive properties for applications in nuclear medicine. Because PNAs have high selectivity for DNA/RNA recognition, resistance to nuclease/protease degradation, and high thermal and radiolytic stabilities, PNA bioconjugates could transform the areas of diagnostic and therapeutic nuclear medicine. In this book chapter, we report on the current developments towards the preparation of radiometal-containing PNA constructs and summarize the protocols for labeling these probes with (99m)Tc, (111)In, (64)Cu, (90)Y, and (177)Lu. More... »

PAGES

37-54

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-62703-553-8_4

DOI

http://dx.doi.org/10.1007/978-1-62703-553-8_4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031391806

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24297349


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