Application of the MIDAS Approach for Analysis of Lysine Acetylation Sites View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2012-12-17

AUTHORS

Caroline A. Evans , John R. Griffiths , Richard D. Unwin , Anthony D. Whetton , Bernard M. Corfe

ABSTRACT

Multiple Reaction Monitoring Initiated Detection and Sequencing (MIDAS™) is a mass spectrometry-based technique for the detection and characterization of specific post-translational modifications (Unwin et al. 4:1134–1144, 2005), for example acetylated lysine residues (Griffiths et al. 18:1423–1428, 2007). The MIDAS™ technique has application for discovery and analysis of acetylation sites. It is a hypothesis-driven approach that requires a priori knowledge of the primary sequence of the target protein and a proteolytic digest of this protein. MIDAS essentially performs a targeted search for the presence of modified, for example acetylated, peptides. The detection is based on the combination of the predicted molecular weight (measured as mass–charge ratio) of the acetylated proteolytic peptide and a diagnostic fragment (product ion of m/z 126.1), which is generated by specific fragmentation of acetylated peptides during collision induced dissociation performed in tandem mass spectrometry (MS) analysis. Sequence information is subsequently obtained which enables acetylation site assignment. The technique of MIDAS was later trademarked by ABSciex for targeted protein analysis where an MRM scan is combined with full MS/MS product ion scan to enable sequence confirmation. More... »

PAGES

25-36

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-62703-305-3_3

DOI

http://dx.doi.org/10.1007/978-1-62703-305-3_3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053116596

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23381851


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215 Paterson Institute for Cancer Research, University of Manchester, Manchester, UK
216 School of Cancer and Enabling Sciences, Wolfson Molecular Imaging Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
217 schema:name Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust and School of Medicine, University of Manchester, Manchester, UK
218 Paterson Institute for Cancer Research, University of Manchester, Manchester, UK
219 School of Cancer and Enabling Sciences, Wolfson Molecular Imaging Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
220 rdf:type schema:Organization
 




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