Systems Toxicology from Genes to Organs View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2013

AUTHORS

John Jack , John Wambaugh , Imran Shah

ABSTRACT

This unique overview of systems toxicology methods and techniques begins with a brief account of systems thinking in biology over the last century. We discuss how systems biology and toxicology continue to leverage advances in computational modeling, informatics, large-scale computing, and biotechnology. Next, we chart the genesis of systems toxicology from previous work in physiologically based models, models of early development, and more recently, molecular systems biology. For readers interested in further details this background provides useful linkages to the relevant literature. It also lays the foundations for new ideas in systems toxicology that could translate laboratory measurements of molecular responses from xenobiotic perturbations to adverse organ level effects in humans. By providing innovative solutions across disciplinary boundaries and highlighting key scientific gaps, we believe this chapter provides useful information about the current state, and valuable insight about future directions in systems toxicity. More... »

PAGES

375-97

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-62703-059-5_17

    DOI

    http://dx.doi.org/10.1007/978-1-62703-059-5_17

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019767293

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23086851


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