PEGylation of Antibody Fragments for Half-Life Extension View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2012

AUTHORS

Simona Jevševar , Mateja Kusterle , Maja Kenig

ABSTRACT

Antibody fragments (Fab's) represent important structure for creating new therapeutics. Compared to full antibodies Fab' fragments possess certain advantages, including higher mobility and tissue penetration, ability to bind antigen monovalently and lack of fragment crystallizable (Fc) region-mediated functions such as antibody-dependent cell mediated cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC). The main drawback for the use of Fab's in clinical applications is associated with their short half-life in vivo, which is a consequence of no longer having the Fc region. To exert meaningful clinical effects, the half-life of Fab's need to be extended, which has been achieved by postproduction chemical attachment of polyethylene glycol (PEG) chain to protein using PEGylation technology. The most suitable approach employs PEG-maleimide attachment to cysteines, either to the free hinge cysteine or to C-terminal cysteines involved in interchain disulfide linkage of the heavy and light chain. Hence, protocols for mono-PEGylation of Fab via free cysteine in the hinge region and di-PEGylation of Fab via interchain disulfide bridge are provided in this chapter. More... »

PAGES

233-46

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-61779-931-0_15

DOI

http://dx.doi.org/10.1007/978-1-61779-931-0_15

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029200759

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22723105


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin Fab Fragments", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polyethylene Glycols", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Sandoz Biopharmaceuticals, Menge\u0161, Lek Pharmaceuticals d.d, Menge\u0161, Slovenia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jev\u0161evar", 
        "givenName": "Simona", 
        "id": "sg:person.0626550320.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626550320.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Sandoz Biopharmaceuticals, Menge\u0161, Lek Pharmaceuticals d.d, Menge\u0161, Slovenia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kusterle", 
        "givenName": "Mateja", 
        "id": "sg:person.01241567120.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241567120.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Sandoz Biopharmaceuticals, Menge\u0161, Lek Pharmaceuticals d.d, Menge\u0161, Slovenia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kenig", 
        "givenName": "Maja", 
        "id": "sg:person.01136422100.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136422100.83"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.2165/00063030-200923020-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001338842", 
          "https://doi.org/10.2165/00063030-200923020-00003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00063030-200923020-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001338842", 
          "https://doi.org/10.2165/00063030-200923020-00003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(92)90460-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001595229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0471140864.ps0609s55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003778946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/cyto.2001.0936", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004639488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/17425240802650568", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008037108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc1002746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008425353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc1002746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008425353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc700319r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010614092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc700319r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010614092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc0601471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014928236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc0601471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014928236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coi.2008.05.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018017632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/protein/gzm015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018298363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0471140864.ps0610s55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023573656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jps.21170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036429275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jbiotec.2006.12.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036818509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/17425247.2011.602399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039764451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/biot.200900218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041844792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/biot.200900218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041844792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0169-409x(02)00023-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046537803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/11717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049234928", 
          "https://doi.org/10.1038/11717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/11717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049234928", 
          "https://doi.org/10.1038/11717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pep.2009.04.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050335364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053080459", 
          "https://doi.org/10.1038/nchembio786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053080459", 
          "https://doi.org/10.1038/nchembio786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3000116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062686454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3000116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062686454"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012", 
    "datePublishedReg": "2012-01-01", 
    "description": "Antibody fragments (Fab's) represent important structure for creating new therapeutics. Compared to full antibodies Fab' fragments possess certain advantages, including higher mobility and tissue penetration, ability to bind antigen monovalently and lack of fragment crystallizable (Fc) region-mediated functions such as antibody-dependent cell mediated cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC). The main drawback for the use of Fab's in clinical applications is associated with their short half-life in vivo, which is a consequence of no longer having the Fc region. To exert meaningful clinical effects, the half-life of Fab's need to be extended, which has been achieved by postproduction chemical attachment of polyethylene glycol (PEG) chain to protein using PEGylation technology. The most suitable approach employs PEG-maleimide attachment to cysteines, either to the free hinge cysteine or to C-terminal cysteines involved in interchain disulfide linkage of the heavy and light chain. Hence, protocols for mono-PEGylation of Fab via free cysteine in the hinge region and di-PEGylation of Fab via interchain disulfide bridge are provided in this chapter.", 
    "editor": [
      {
        "familyName": "Proetzel", 
        "givenName": "Gabriele", 
        "type": "Person"
      }, 
      {
        "familyName": "Ebersbach", 
        "givenName": "Hilmar", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-61779-931-0_15", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-61779-930-3", 
        "978-1-61779-931-0"
      ], 
      "name": "Antibody Methods and Protocols", 
      "type": "Book"
    }, 
    "name": "PEGylation of Antibody Fragments for Half-Life Extension", 
    "pagination": "233-46", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-61779-931-0_15"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8b1bdcf92e3d935d5b99d94027c0174808677cee54840f4528dd796e6b1fd8c2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1029200759"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22723105"
        ]
      }
    ], 
    "publisher": {
      "location": "Totowa, NJ", 
      "name": "Humana Press", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-61779-931-0_15", 
      "https://app.dimensions.ai/details/publication/pub.1029200759"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T21:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000261.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-1-61779-931-0_15"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-61779-931-0_15'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-61779-931-0_15'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-61779-931-0_15'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-61779-931-0_15'


 

This table displays all metadata directly associated to this object as RDF triples.

174 TRIPLES      23 PREDICATES      53 URIs      26 LITERALS      14 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-61779-931-0_15 schema:about N0a17ae8d9f274ce9a1408fb25e2c4ba7
2 N18405827e1c144989023a881c095c899
3 Nc09fb302d46141ef84abcc35c59a63ca
4 Ne28c8b36278f47b894bc1f0c5dfcc880
5 Nec0b4d4b3d224f67ba2a480e87d229ef
6 anzsrc-for:06
7 anzsrc-for:0601
8 schema:author Nd305ef04566c48ef845a3a7528137db3
9 schema:citation sg:pub.10.1038/11717
10 sg:pub.10.1038/nchembio786
11 sg:pub.10.2165/00063030-200923020-00003
12 https://doi.org/10.1002/0471140864.ps0609s55
13 https://doi.org/10.1002/0471140864.ps0610s55
14 https://doi.org/10.1002/biot.200900218
15 https://doi.org/10.1002/jps.21170
16 https://doi.org/10.1006/cyto.2001.0936
17 https://doi.org/10.1016/0003-2697(92)90460-o
18 https://doi.org/10.1016/j.coi.2008.05.010
19 https://doi.org/10.1016/j.jbiotec.2006.12.020
20 https://doi.org/10.1016/j.pep.2009.04.012
21 https://doi.org/10.1016/s0169-409x(02)00023-6
22 https://doi.org/10.1021/bc0601471
23 https://doi.org/10.1021/bc1002746
24 https://doi.org/10.1021/bc700319r
25 https://doi.org/10.1093/protein/gzm015
26 https://doi.org/10.1126/scitranslmed.3000116
27 https://doi.org/10.1517/17425240802650568
28 https://doi.org/10.1517/17425247.2011.602399
29 schema:datePublished 2012
30 schema:datePublishedReg 2012-01-01
31 schema:description Antibody fragments (Fab's) represent important structure for creating new therapeutics. Compared to full antibodies Fab' fragments possess certain advantages, including higher mobility and tissue penetration, ability to bind antigen monovalently and lack of fragment crystallizable (Fc) region-mediated functions such as antibody-dependent cell mediated cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC). The main drawback for the use of Fab's in clinical applications is associated with their short half-life in vivo, which is a consequence of no longer having the Fc region. To exert meaningful clinical effects, the half-life of Fab's need to be extended, which has been achieved by postproduction chemical attachment of polyethylene glycol (PEG) chain to protein using PEGylation technology. The most suitable approach employs PEG-maleimide attachment to cysteines, either to the free hinge cysteine or to C-terminal cysteines involved in interchain disulfide linkage of the heavy and light chain. Hence, protocols for mono-PEGylation of Fab via free cysteine in the hinge region and di-PEGylation of Fab via interchain disulfide bridge are provided in this chapter.
32 schema:editor N918e56b890a549bab28e7642ac1fea6e
33 schema:genre chapter
34 schema:inLanguage en
35 schema:isAccessibleForFree false
36 schema:isPartOf Nd4bd8a3f8402415da285440c5795ce90
37 schema:name PEGylation of Antibody Fragments for Half-Life Extension
38 schema:pagination 233-46
39 schema:productId N03f7ff9a8c1e4419a945ee1145162644
40 N2a9ea66748914dfbb2057307785db205
41 N525f084eee5c4d0a9dc1163e74ea0ff2
42 Nd6b2c86f8d38465a836258555555bfd9
43 schema:publisher N962d459abf214954aeeb9407676fc7d3
44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029200759
45 https://doi.org/10.1007/978-1-61779-931-0_15
46 schema:sdDatePublished 2019-04-15T21:02
47 schema:sdLicense https://scigraph.springernature.com/explorer/license/
48 schema:sdPublisher Ne9cd14bbe2cd4dda9405deb7b1bc0bb5
49 schema:url http://link.springer.com/10.1007/978-1-61779-931-0_15
50 sgo:license sg:explorer/license/
51 sgo:sdDataset chapters
52 rdf:type schema:Chapter
53 N03f7ff9a8c1e4419a945ee1145162644 schema:name doi
54 schema:value 10.1007/978-1-61779-931-0_15
55 rdf:type schema:PropertyValue
56 N0a17ae8d9f274ce9a1408fb25e2c4ba7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
57 schema:name Animals
58 rdf:type schema:DefinedTerm
59 N0ccaf172ec5e4dd18707dab3aa9ee394 rdf:first sg:person.01136422100.83
60 rdf:rest rdf:nil
61 N18405827e1c144989023a881c095c899 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
62 schema:name Polyethylene Glycols
63 rdf:type schema:DefinedTerm
64 N2a9ea66748914dfbb2057307785db205 schema:name readcube_id
65 schema:value 8b1bdcf92e3d935d5b99d94027c0174808677cee54840f4528dd796e6b1fd8c2
66 rdf:type schema:PropertyValue
67 N525f084eee5c4d0a9dc1163e74ea0ff2 schema:name pubmed_id
68 schema:value 22723105
69 rdf:type schema:PropertyValue
70 N55a0df5a894c4e66be34e11b810cd744 rdf:first Nf2aff329483040fc89e1a8f3c2e39787
71 rdf:rest rdf:nil
72 N741805ae82c14c91a20158b440f01bda rdf:first sg:person.01241567120.18
73 rdf:rest N0ccaf172ec5e4dd18707dab3aa9ee394
74 N89fdb1f5a3ef48bcacfba7006d78aa66 schema:name Sandoz Biopharmaceuticals, Mengeš, Lek Pharmaceuticals d.d, Mengeš, Slovenia
75 rdf:type schema:Organization
76 N918e56b890a549bab28e7642ac1fea6e rdf:first Nfc3a915fcbab4266a9f9c42c0254423a
77 rdf:rest N55a0df5a894c4e66be34e11b810cd744
78 N954c87dbe6fa4742b31549deac8a3720 schema:name Sandoz Biopharmaceuticals, Mengeš, Lek Pharmaceuticals d.d, Mengeš, Slovenia
79 rdf:type schema:Organization
80 N962d459abf214954aeeb9407676fc7d3 schema:location Totowa, NJ
81 schema:name Humana Press
82 rdf:type schema:Organisation
83 Nc09fb302d46141ef84abcc35c59a63ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Antibodies
85 rdf:type schema:DefinedTerm
86 Nc84ab5b22fd7443d9df16d70a8506550 schema:name Sandoz Biopharmaceuticals, Mengeš, Lek Pharmaceuticals d.d, Mengeš, Slovenia
87 rdf:type schema:Organization
88 Nd305ef04566c48ef845a3a7528137db3 rdf:first sg:person.0626550320.50
89 rdf:rest N741805ae82c14c91a20158b440f01bda
90 Nd4bd8a3f8402415da285440c5795ce90 schema:isbn 978-1-61779-930-3
91 978-1-61779-931-0
92 schema:name Antibody Methods and Protocols
93 rdf:type schema:Book
94 Nd6b2c86f8d38465a836258555555bfd9 schema:name dimensions_id
95 schema:value pub.1029200759
96 rdf:type schema:PropertyValue
97 Ne28c8b36278f47b894bc1f0c5dfcc880 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Immunoglobulin Fab Fragments
99 rdf:type schema:DefinedTerm
100 Ne9cd14bbe2cd4dda9405deb7b1bc0bb5 schema:name Springer Nature - SN SciGraph project
101 rdf:type schema:Organization
102 Nec0b4d4b3d224f67ba2a480e87d229ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Humans
104 rdf:type schema:DefinedTerm
105 Nf2aff329483040fc89e1a8f3c2e39787 schema:familyName Ebersbach
106 schema:givenName Hilmar
107 rdf:type schema:Person
108 Nfc3a915fcbab4266a9f9c42c0254423a schema:familyName Proetzel
109 schema:givenName Gabriele
110 rdf:type schema:Person
111 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
112 schema:name Biological Sciences
113 rdf:type schema:DefinedTerm
114 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
115 schema:name Biochemistry and Cell Biology
116 rdf:type schema:DefinedTerm
117 sg:person.01136422100.83 schema:affiliation N89fdb1f5a3ef48bcacfba7006d78aa66
118 schema:familyName Kenig
119 schema:givenName Maja
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136422100.83
121 rdf:type schema:Person
122 sg:person.01241567120.18 schema:affiliation N954c87dbe6fa4742b31549deac8a3720
123 schema:familyName Kusterle
124 schema:givenName Mateja
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241567120.18
126 rdf:type schema:Person
127 sg:person.0626550320.50 schema:affiliation Nc84ab5b22fd7443d9df16d70a8506550
128 schema:familyName Jevševar
129 schema:givenName Simona
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626550320.50
131 rdf:type schema:Person
132 sg:pub.10.1038/11717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049234928
133 https://doi.org/10.1038/11717
134 rdf:type schema:CreativeWork
135 sg:pub.10.1038/nchembio786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053080459
136 https://doi.org/10.1038/nchembio786
137 rdf:type schema:CreativeWork
138 sg:pub.10.2165/00063030-200923020-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001338842
139 https://doi.org/10.2165/00063030-200923020-00003
140 rdf:type schema:CreativeWork
141 https://doi.org/10.1002/0471140864.ps0609s55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003778946
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1002/0471140864.ps0610s55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023573656
144 rdf:type schema:CreativeWork
145 https://doi.org/10.1002/biot.200900218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041844792
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1002/jps.21170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036429275
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1006/cyto.2001.0936 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004639488
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1016/0003-2697(92)90460-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1001595229
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1016/j.coi.2008.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018017632
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1016/j.jbiotec.2006.12.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036818509
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1016/j.pep.2009.04.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050335364
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1016/s0169-409x(02)00023-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046537803
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1021/bc0601471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014928236
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1021/bc1002746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008425353
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1021/bc700319r schema:sameAs https://app.dimensions.ai/details/publication/pub.1010614092
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1093/protein/gzm015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018298363
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1126/scitranslmed.3000116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062686454
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1517/17425240802650568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008037108
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1517/17425247.2011.602399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039764451
174 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...