PEGylation of Antibody Fragments for Half-Life Extension View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2012

AUTHORS

Simona Jevševar , Mateja Kusterle , Maja Kenig

ABSTRACT

Antibody fragments (Fab's) represent important structure for creating new therapeutics. Compared to full antibodies Fab' fragments possess certain advantages, including higher mobility and tissue penetration, ability to bind antigen monovalently and lack of fragment crystallizable (Fc) region-mediated functions such as antibody-dependent cell mediated cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC). The main drawback for the use of Fab's in clinical applications is associated with their short half-life in vivo, which is a consequence of no longer having the Fc region. To exert meaningful clinical effects, the half-life of Fab's need to be extended, which has been achieved by postproduction chemical attachment of polyethylene glycol (PEG) chain to protein using PEGylation technology. The most suitable approach employs PEG-maleimide attachment to cysteines, either to the free hinge cysteine or to C-terminal cysteines involved in interchain disulfide linkage of the heavy and light chain. Hence, protocols for mono-PEGylation of Fab via free cysteine in the hinge region and di-PEGylation of Fab via interchain disulfide bridge are provided in this chapter. More... »

PAGES

233-46

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-61779-931-0_15

DOI

http://dx.doi.org/10.1007/978-1-61779-931-0_15

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029200759

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22723105


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin Fab Fragments", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polyethylene Glycols", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Sandoz Biopharmaceuticals, Menge\u0161, Lek Pharmaceuticals d.d, Menge\u0161, Slovenia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jev\u0161evar", 
        "givenName": "Simona", 
        "id": "sg:person.0626550320.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626550320.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Sandoz Biopharmaceuticals, Menge\u0161, Lek Pharmaceuticals d.d, Menge\u0161, Slovenia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kusterle", 
        "givenName": "Mateja", 
        "id": "sg:person.01241567120.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241567120.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Sandoz Biopharmaceuticals, Menge\u0161, Lek Pharmaceuticals d.d, Menge\u0161, Slovenia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kenig", 
        "givenName": "Maja", 
        "id": "sg:person.01136422100.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136422100.83"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.2165/00063030-200923020-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001338842", 
          "https://doi.org/10.2165/00063030-200923020-00003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00063030-200923020-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001338842", 
          "https://doi.org/10.2165/00063030-200923020-00003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(92)90460-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001595229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0471140864.ps0609s55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003778946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/cyto.2001.0936", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004639488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/17425240802650568", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008037108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc1002746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008425353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc1002746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008425353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc700319r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010614092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc700319r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010614092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc0601471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014928236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc0601471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014928236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coi.2008.05.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018017632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/protein/gzm015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018298363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0471140864.ps0610s55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023573656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jps.21170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036429275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jbiotec.2006.12.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036818509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/17425247.2011.602399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039764451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/biot.200900218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041844792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/biot.200900218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041844792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0169-409x(02)00023-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046537803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/11717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049234928", 
          "https://doi.org/10.1038/11717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/11717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049234928", 
          "https://doi.org/10.1038/11717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pep.2009.04.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050335364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053080459", 
          "https://doi.org/10.1038/nchembio786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053080459", 
          "https://doi.org/10.1038/nchembio786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3000116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062686454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3000116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062686454"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012", 
    "datePublishedReg": "2012-01-01", 
    "description": "Antibody fragments (Fab's) represent important structure for creating new therapeutics. Compared to full antibodies Fab' fragments possess certain advantages, including higher mobility and tissue penetration, ability to bind antigen monovalently and lack of fragment crystallizable (Fc) region-mediated functions such as antibody-dependent cell mediated cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC). The main drawback for the use of Fab's in clinical applications is associated with their short half-life in vivo, which is a consequence of no longer having the Fc region. To exert meaningful clinical effects, the half-life of Fab's need to be extended, which has been achieved by postproduction chemical attachment of polyethylene glycol (PEG) chain to protein using PEGylation technology. The most suitable approach employs PEG-maleimide attachment to cysteines, either to the free hinge cysteine or to C-terminal cysteines involved in interchain disulfide linkage of the heavy and light chain. Hence, protocols for mono-PEGylation of Fab via free cysteine in the hinge region and di-PEGylation of Fab via interchain disulfide bridge are provided in this chapter.", 
    "editor": [
      {
        "familyName": "Proetzel", 
        "givenName": "Gabriele", 
        "type": "Person"
      }, 
      {
        "familyName": "Ebersbach", 
        "givenName": "Hilmar", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-61779-931-0_15", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-61779-930-3", 
        "978-1-61779-931-0"
      ], 
      "name": "Antibody Methods and Protocols", 
      "type": "Book"
    }, 
    "name": "PEGylation of Antibody Fragments for Half-Life Extension", 
    "pagination": "233-46", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-61779-931-0_15"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8b1bdcf92e3d935d5b99d94027c0174808677cee54840f4528dd796e6b1fd8c2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1029200759"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22723105"
        ]
      }
    ], 
    "publisher": {
      "location": "Totowa, NJ", 
      "name": "Humana Press", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-61779-931-0_15", 
      "https://app.dimensions.ai/details/publication/pub.1029200759"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T21:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000261.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-1-61779-931-0_15"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-61779-931-0_15'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-61779-931-0_15'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-61779-931-0_15'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-61779-931-0_15'


 

This table displays all metadata directly associated to this object as RDF triples.

174 TRIPLES      23 PREDICATES      53 URIs      26 LITERALS      14 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-61779-931-0_15 schema:about N5bd77a1d96804221833a553fabb242b0
2 N62093d1eb81c44039ec5307074c15605
3 N6452af52af3847818d5b61481f242134
4 Nb43fc38c987440efb82272303521ca99
5 Neb14b579655d44d5bae95f332d602bf9
6 anzsrc-for:06
7 anzsrc-for:0601
8 schema:author N9d12491f7aaf4081953e25992cc89683
9 schema:citation sg:pub.10.1038/11717
10 sg:pub.10.1038/nchembio786
11 sg:pub.10.2165/00063030-200923020-00003
12 https://doi.org/10.1002/0471140864.ps0609s55
13 https://doi.org/10.1002/0471140864.ps0610s55
14 https://doi.org/10.1002/biot.200900218
15 https://doi.org/10.1002/jps.21170
16 https://doi.org/10.1006/cyto.2001.0936
17 https://doi.org/10.1016/0003-2697(92)90460-o
18 https://doi.org/10.1016/j.coi.2008.05.010
19 https://doi.org/10.1016/j.jbiotec.2006.12.020
20 https://doi.org/10.1016/j.pep.2009.04.012
21 https://doi.org/10.1016/s0169-409x(02)00023-6
22 https://doi.org/10.1021/bc0601471
23 https://doi.org/10.1021/bc1002746
24 https://doi.org/10.1021/bc700319r
25 https://doi.org/10.1093/protein/gzm015
26 https://doi.org/10.1126/scitranslmed.3000116
27 https://doi.org/10.1517/17425240802650568
28 https://doi.org/10.1517/17425247.2011.602399
29 schema:datePublished 2012
30 schema:datePublishedReg 2012-01-01
31 schema:description Antibody fragments (Fab's) represent important structure for creating new therapeutics. Compared to full antibodies Fab' fragments possess certain advantages, including higher mobility and tissue penetration, ability to bind antigen monovalently and lack of fragment crystallizable (Fc) region-mediated functions such as antibody-dependent cell mediated cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC). The main drawback for the use of Fab's in clinical applications is associated with their short half-life in vivo, which is a consequence of no longer having the Fc region. To exert meaningful clinical effects, the half-life of Fab's need to be extended, which has been achieved by postproduction chemical attachment of polyethylene glycol (PEG) chain to protein using PEGylation technology. The most suitable approach employs PEG-maleimide attachment to cysteines, either to the free hinge cysteine or to C-terminal cysteines involved in interchain disulfide linkage of the heavy and light chain. Hence, protocols for mono-PEGylation of Fab via free cysteine in the hinge region and di-PEGylation of Fab via interchain disulfide bridge are provided in this chapter.
32 schema:editor N3842f8943a1b45a4a918dccca09affb0
33 schema:genre chapter
34 schema:inLanguage en
35 schema:isAccessibleForFree false
36 schema:isPartOf N669210696ae543f2b30673c67fdd1283
37 schema:name PEGylation of Antibody Fragments for Half-Life Extension
38 schema:pagination 233-46
39 schema:productId N16309c0d11864b938ce0231b69972a90
40 N9b240c8054214c5ab0704e323c54963f
41 Na1b81c7316d94cfaa7c94baa0a337733
42 Nde31d5acb2c54a75b4c51edaee717d9e
43 schema:publisher N2a5aefbfc7ad44f4af6d1ca7cdd9e872
44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029200759
45 https://doi.org/10.1007/978-1-61779-931-0_15
46 schema:sdDatePublished 2019-04-15T21:02
47 schema:sdLicense https://scigraph.springernature.com/explorer/license/
48 schema:sdPublisher Na2dbf9e2c86141cfb0451f9f23a85b31
49 schema:url http://link.springer.com/10.1007/978-1-61779-931-0_15
50 sgo:license sg:explorer/license/
51 sgo:sdDataset chapters
52 rdf:type schema:Chapter
53 N16309c0d11864b938ce0231b69972a90 schema:name readcube_id
54 schema:value 8b1bdcf92e3d935d5b99d94027c0174808677cee54840f4528dd796e6b1fd8c2
55 rdf:type schema:PropertyValue
56 N1dbe7b3f967f43e480d88a5da4058e9e rdf:first Nd16cf075494c4184a3843e9f8026d010
57 rdf:rest rdf:nil
58 N2a5aefbfc7ad44f4af6d1ca7cdd9e872 schema:location Totowa, NJ
59 schema:name Humana Press
60 rdf:type schema:Organisation
61 N3842f8943a1b45a4a918dccca09affb0 rdf:first Ndfcc9f95d94c434eac7f05b0730cc3a8
62 rdf:rest N1dbe7b3f967f43e480d88a5da4058e9e
63 N4a45568a03194a6fa04e09ab450fe75c schema:name Sandoz Biopharmaceuticals, Mengeš, Lek Pharmaceuticals d.d, Mengeš, Slovenia
64 rdf:type schema:Organization
65 N5bd77a1d96804221833a553fabb242b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Humans
67 rdf:type schema:DefinedTerm
68 N62093d1eb81c44039ec5307074c15605 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Antibodies
70 rdf:type schema:DefinedTerm
71 N6452af52af3847818d5b61481f242134 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Animals
73 rdf:type schema:DefinedTerm
74 N669210696ae543f2b30673c67fdd1283 schema:isbn 978-1-61779-930-3
75 978-1-61779-931-0
76 schema:name Antibody Methods and Protocols
77 rdf:type schema:Book
78 N70653d2c97d341439d9c5e90fe0a6f39 schema:name Sandoz Biopharmaceuticals, Mengeš, Lek Pharmaceuticals d.d, Mengeš, Slovenia
79 rdf:type schema:Organization
80 N927de89ee0e94201af306bf140998d2d rdf:first sg:person.01136422100.83
81 rdf:rest rdf:nil
82 N9b240c8054214c5ab0704e323c54963f schema:name dimensions_id
83 schema:value pub.1029200759
84 rdf:type schema:PropertyValue
85 N9d12491f7aaf4081953e25992cc89683 rdf:first sg:person.0626550320.50
86 rdf:rest Nc93a5bca628b4807899e2f4dd5306831
87 Na1b81c7316d94cfaa7c94baa0a337733 schema:name pubmed_id
88 schema:value 22723105
89 rdf:type schema:PropertyValue
90 Na2dbf9e2c86141cfb0451f9f23a85b31 schema:name Springer Nature - SN SciGraph project
91 rdf:type schema:Organization
92 Nb43fc38c987440efb82272303521ca99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Polyethylene Glycols
94 rdf:type schema:DefinedTerm
95 Nc93a5bca628b4807899e2f4dd5306831 rdf:first sg:person.01241567120.18
96 rdf:rest N927de89ee0e94201af306bf140998d2d
97 Nd16cf075494c4184a3843e9f8026d010 schema:familyName Ebersbach
98 schema:givenName Hilmar
99 rdf:type schema:Person
100 Nde31d5acb2c54a75b4c51edaee717d9e schema:name doi
101 schema:value 10.1007/978-1-61779-931-0_15
102 rdf:type schema:PropertyValue
103 Ndfcc9f95d94c434eac7f05b0730cc3a8 schema:familyName Proetzel
104 schema:givenName Gabriele
105 rdf:type schema:Person
106 Neb14b579655d44d5bae95f332d602bf9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Immunoglobulin Fab Fragments
108 rdf:type schema:DefinedTerm
109 Nfc0f883fa9894100b28ea471a6234600 schema:name Sandoz Biopharmaceuticals, Mengeš, Lek Pharmaceuticals d.d, Mengeš, Slovenia
110 rdf:type schema:Organization
111 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
112 schema:name Biological Sciences
113 rdf:type schema:DefinedTerm
114 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
115 schema:name Biochemistry and Cell Biology
116 rdf:type schema:DefinedTerm
117 sg:person.01136422100.83 schema:affiliation N70653d2c97d341439d9c5e90fe0a6f39
118 schema:familyName Kenig
119 schema:givenName Maja
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136422100.83
121 rdf:type schema:Person
122 sg:person.01241567120.18 schema:affiliation N4a45568a03194a6fa04e09ab450fe75c
123 schema:familyName Kusterle
124 schema:givenName Mateja
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241567120.18
126 rdf:type schema:Person
127 sg:person.0626550320.50 schema:affiliation Nfc0f883fa9894100b28ea471a6234600
128 schema:familyName Jevševar
129 schema:givenName Simona
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626550320.50
131 rdf:type schema:Person
132 sg:pub.10.1038/11717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049234928
133 https://doi.org/10.1038/11717
134 rdf:type schema:CreativeWork
135 sg:pub.10.1038/nchembio786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053080459
136 https://doi.org/10.1038/nchembio786
137 rdf:type schema:CreativeWork
138 sg:pub.10.2165/00063030-200923020-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001338842
139 https://doi.org/10.2165/00063030-200923020-00003
140 rdf:type schema:CreativeWork
141 https://doi.org/10.1002/0471140864.ps0609s55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003778946
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1002/0471140864.ps0610s55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023573656
144 rdf:type schema:CreativeWork
145 https://doi.org/10.1002/biot.200900218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041844792
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1002/jps.21170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036429275
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1006/cyto.2001.0936 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004639488
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1016/0003-2697(92)90460-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1001595229
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1016/j.coi.2008.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018017632
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1016/j.jbiotec.2006.12.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036818509
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1016/j.pep.2009.04.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050335364
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1016/s0169-409x(02)00023-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046537803
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1021/bc0601471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014928236
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1021/bc1002746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008425353
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1021/bc700319r schema:sameAs https://app.dimensions.ai/details/publication/pub.1010614092
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1093/protein/gzm015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018298363
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1126/scitranslmed.3000116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062686454
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1517/17425240802650568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008037108
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1517/17425247.2011.602399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039764451
174 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...