Array-Comparative Genomic Hybridization Characterization of Human Pluripotent Stem Cells View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2012

AUTHORS

Aaron M. Elliott , Kristi A. Hohenstein Elliott , Anja Kammesheidt

ABSTRACT

During culture adaptation, human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) tend to acquire chromosomal aberrations. Generally, stem cell lines are screened for large-scale chromosomal changes using low resolution karyotype analysis. Recent studies characterizing human stem cells using array-comparative genomic hybridization (aCGH) suggests most abnormalities acquired during culture are under the resolution of karyotype analysis and therefore are routinely missed. Here, we describe a custom-designed stem cell focused microarray utilizing 44K probes, with increased resolution in relevant stem cell-associated and cancer-related genes. More... »

PAGES

261-7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-61779-794-1_17

DOI

http://dx.doi.org/10.1007/978-1-61779-794-1_17

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005419853

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22528361


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