Analysis of the Role of RhoGDI1 and Isoprenylation in the Degradation of RhoGTPases View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2012

AUTHORS

Etienne Boulter , Rafael Garcia-Mata

ABSTRACT

RhoGDI1 is one of the three major regulators of the Rho switch along with RhoGEFs and RhoGAPs. RhoGDI1 extracts prenylated Rho proteins from lipid membranes, sequesters them in the cytosol, and prevents nucleotide exchange or hydrolysis. In addition, RhoGDI1 protects prenylated Rho proteins from degradation. Here, we describe techniques to monitor Rho proteins degradation upon depletion of RhoGDI1 and their dependence upon prenylation for degradation. More... »

PAGES

97-105

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-61779-442-1_7

DOI

http://dx.doi.org/10.1007/978-1-61779-442-1_7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052764866

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22144270


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