Exploring Functional In Vivo Consequences of the Selective Genetic Ablation of mTOR Signaling in T Helper Lymphocytes View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2012

AUTHORS

Greg M. Delgoffe , Jonathan D. Powell

ABSTRACT

The mammalian Target of Rapamycin (mTOR) defines a crucial link between nutrient sensing and immune function. In CD4+ T cells, mTOR has been shown to play a critical role in regulating effector and regulatory T cell differentiation as well as the decision between full activation versus the induction of anergy. In this chapter, we describe how our group has employed the Cre-lox technology to genetically delete components of the mTOR signaling complex in T cells. This has enabled us to specifically interrogate mTOR function in T cells both in vitro and in vivo. We also describe techniques used to assay immune function and signaling in mTOR-deficient T cells at the single-cell level. More... »

PAGES

317-27

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-61779-430-8_20

DOI

http://dx.doi.org/10.1007/978-1-61779-430-8_20

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000839200

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22125075


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