Adoptive Cell Therapy for the Treatment of Metastatic Melanoma View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2012

AUTHORS

Jessica Ann Chacon , Patrick Hwu , Laszlo G. Radvanyi

ABSTRACT

Adoptive transfer of autologous tumor-reactive T cells as an immunotherapy for melanoma patients has been evaluated in various forms over the past two decades. Major therapeutic successes have emerged recently as methods to improve T cell culture techniques, optimize host conditioning, and augment persistence of transferred T cells have been pursued. A major leap forward occurred when lymphodepleting regimens were introduced for host conditioning, which liberates availability of homeostatic cytokines and depletes regulatory cell populations. Clinical response rates of over 50% have been observed in patients eligible for this therapy. Newer approaches of transduction of antigen-specific TCR or chimeric receptor constructs, use of better functionally defined T cell clones, and artificial antigen-presenting cells to expand specific T cells from peripheral blood cells are all showing promise. The time may be ripe for organizing a multicenter trial to establish the efficacy of this therapy and hopefully elevate it to a standard of care in specialized centers. More... »

PAGES

233-272

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  • Book

    TITLE

    Targeted Therapeutics in Melanoma

    ISBN

    978-1-61779-406-3
    978-1-61779-407-0

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-61779-407-0_13

    DOI

    http://dx.doi.org/10.1007/978-1-61779-407-0_13

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020300055


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