Renoprotective Effects of C-Peptide on Type 1 Diabetes View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2012

AUTHORS

Lina Nordquist , Åsa Kallas , Sara Stridh , Fredrik Palm , John Wahren

ABSTRACT

Approximately 30% of type 1 diabetes patients develop nephropathy within 10–20 years of the onset of diabetes. Initial glomerular hyperfiltration and early microalbuminuria are commonly followed by progressive deterioration of the glomerular filtration rate (GFR), pronounced albuminuria and eventually the development of end stage renal disease (ESRD), a condition accompanied by 18-fold increased mortality [1]. In addition, retinopathy, hypertension, and cardiovascular disease are frequent co-morbidities attesting to the severity and complexity of the diabetic nephropathy. The first reports of beneficial effects of C-peptide on the diabetic kidney were published by Johansson et al. [2]. In this chapter, we summarize the last 20 years of research on the effects of C-peptide on diabetic nephropathy with regard to both basic science and clinical findings. More... »

PAGES

67-77

References to SciGraph publications

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  • Book

    TITLE

    Diabetes & C-Peptide

    ISBN

    978-1-61779-390-5
    978-1-61779-391-2

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-61779-391-2_7

    DOI

    http://dx.doi.org/10.1007/978-1-61779-391-2_7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1039410316


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