Ligand Discovery Using Small-Molecule Microarrays View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2012

AUTHORS

Dominick E. Casalena , Dina Wassaf , Angela N. Koehler

ABSTRACT

Genome-wide association studies and genetic linkage studies have created a growing list of proteins related to disease. Small molecules can serve as useful probes of function for these proteins in a cellular setting or may serve as leads for therapeutic development. High-throughput and general binding assays may provide a path for discovering small molecules that target proteins for which little is known about structure or function or for which conventional functional assays have failed. One such binding assay involves small-molecule microarrays (SMMs) containing compounds that have been arrayed and immobilized onto a solid support. The SMMs can be incubated with a protein target of interest and protein-small molecule interactions may be detected using a variety of fluorescent readouts. Several suitable methods for manufacturing SMMs exist and different immobilization methods may be more or less preferable for any given application. Here, we describe protocols for covalent capture of small molecules using an isocyanate-coated glass surface and detection of binding using purified protein. More... »

PAGES

249-63

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-61779-364-6_17

DOI

http://dx.doi.org/10.1007/978-1-61779-364-6_17

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002623666

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22065230


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