Determination of the Kinetic On- and Off-Rate of Single Virus–Cell Interactions View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2011-04-15

AUTHORS

Christian Rankl , Linda Wildling , Isabel Neundlinger , Ferry Kienberger , Hermann Gruber , Dieter Blaas , Peter Hinterdorfer

ABSTRACT

Human rhinoviruses are the causative agents of the common cold. The serotypes belonging to the minor receptor group attach to members of the low-density lipoprotein receptor family and enter the host cell via receptor-mediated endocytosis. Receptor binding, the very first step in infection, was characterized by force spectroscopy measurements at the single molecule level. We demonstrate how kinetic on- and off-rate constants can be derived from such experiments carried out with the atomic force microscope. More... »

PAGES

197-210

References to SciGraph publications

  • 2004-05. X-ray structure of a minor group human rhinovirus bound to a fragment of its cellular receptor protein in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2008-07. Viral membrane fusion in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-61779-105-5_13

    DOI

    http://dx.doi.org/10.1007/978-1-61779-105-5_13

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21660729


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