Chemical Screening with Zebrafish Embryos View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2011-01-14

AUTHORS

Hanbing Zhong , Shuo Lin

ABSTRACT

Functional chemicals are very useful tools for molecular biology studies. Due to its small size, large progeny clutch, and embryonic transparency, zebrafish serves as a superb in vivo animal model for chemical compound screens and characterization. During zebrafish embryogenesis, multiple developmental phenotypes can be easily examined under the microscope, therefore allowing a more comprehensive evaluation for identifying novel functional chemicals than cell-based assays. Ever since the first zebrafish-based chemical screen was conducted in the year 2000, many functional chemicals have been discovered using this strategy. In this chapter, we describe how to perform a typical zebrafish-based chemical screen and discuss the details of the protocol by using the example of the identification and characterization of two new Smo inhibitors with a Gli:GFP transgenic line. More... »

PAGES

193-205

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-61779-012-6_12

DOI

http://dx.doi.org/10.1007/978-1-61779-012-6_12

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007120606

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21318908


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