Depletion of Human Regulatory T Cells View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2011-01-07

AUTHORS

Amy C. Hobeika , Michael A. Morse , Takuya Osada , Sharon Peplinski , H. Kim Lyerly , Timothy M. Clay

ABSTRACT

Regulatory T cells (Treg) have become increasingly relevant in the study of human disease including cancer. Treg cells have been shown to inhibit anti-tumor immune responses, and elevated Treg levels have been associated with certain types of cancer. Similarly, depletion of Tregs by various methods can also enhance anti-tumor immune responses. We have found a prevalence of Treg in cancer patients when compared to normal volunteers. In addition, we have shown that the depletion of Treg using the IL-2 fusion protein denileukin diftitox decreased Treg function and increased antigen-specific T cell response to a cancer vaccine. These results indicate the potential for combining Treg depletion with anti-cancer vaccines to enhance tumor antigen-specific immune responses and the need to explore the dose and schedule of Treg depletion strategies in optimizing vaccine efforts. More... »

PAGES

219-231

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-61737-979-6_14

DOI

http://dx.doi.org/10.1007/978-1-61737-979-6_14

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052326278

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21287338


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