Microarray-Based Comparative Genomic Hybridization (Array-CGH) as a Useful Tool for Identifying Genes Involved in Glioblastoma (GB) View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2010-06-15

AUTHORS

Yolanda Ruano , Manuela Mollejo , Angel Rodríguez de Lope , José Luis Hernández-Moneo , Pedro Martínez , Bárbara Meléndez

ABSTRACT

Alterations in the genome that lead to changes in DNA sequence copy number are a characteristic of Glioblastomas (GBs). Microarray-based comparative genomic hybridization (array-CGH) is a high-throughput technology that allows the hybridization of genomic DNA onto conventional cDNA microarrays, normally used in expression profiling, to analyze genomic copy number imbalances. In this way, thousands of genes can be reviewed in a high resolution analysis to define amplicons and to identify? candidate genes showing recurrent genomic copy number changes in GB tumors. More... »

PAGES

35-45

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-60761-759-4_3

DOI

http://dx.doi.org/10.1007/978-1-60761-759-4_3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040891233

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20721736


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