Thioredoxin in the Cardiovascular System—Towards a Thioredoxin-Based Antioxidative Therapy View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2010-08-20

AUTHORS

Cameron World , Bradford C. Berk

ABSTRACT

Oxidative stress results from an imbalance between the production of reactive oxygen species (ROS) and the endogenous antioxidant systems, which detoxify the reactive intermediates. Diseases of the cardiovascular system, including atherosclerosis, diabetes, cardiac hypertrophy, and congestive heart disease are characterized by enhanced production of ROS. In these conditions ROS promote cardiovascular pathology in part by activating inflammatory signaling pathways. One of the principal antioxidant defense mechanisms is the small 12 kDa oxidoreductase, thioredoxin (TRX), that catalyzes the conversion of disulfide oxidized proteins to their thiol-reduced forms. TRX via this catalytic activity confers a protective effect by the ability to regulate pathological signal transduction, inhibit apoptosis, and reduce inflammation. Recent studies using transgenic mice have shown that overexpression of TRX within vascular tissue exerts a protective effect, while injection of recombinant TRX has similarly been demonstrated to possess therapeutic value for the treatment of various vascular diseases. More... »

PAGES

499-516

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-60761-600-9_26

DOI

http://dx.doi.org/10.1007/978-1-60761-600-9_26

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023314350


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