Therapeutic Potential of HDPs as Immunomodulatory Agents View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2009-09-28

AUTHORS

Håvard Jenssen , Robert E. W. Hancock

ABSTRACT

One of the most significant advances in medical history is the discovery and development of antibiotics, which in the middle of last century was flourishing and appeared to be the ultimate solution to the treatment of life-threatening human bacterial diseases. However, lately there has been a huge decline in the rate of discovery of new antimicrobial intervention strategies in parallel with an increasing incidence of multidrug-resistant pathogens; if these circumstances do not change we will continue to approach the end of the antibiotic era. Facing this dark future, scientists are considering new strategies for intervention tailored around the appropriate (selective) stimulation of the host's immune system, and particularly rapid acting innate immunity, as an alternative to direct targeting of microbial pathogens. One recent player in such an immunomodulatory strategy is the naturally occurring host defence peptides (HDP) and their synthetic innate defence regulator (IDR) analogues. In this chapter, we will discuss the potential therapeutic use of HDPs and IDRs as immunomodulatory agents. More... »

PAGES

329-347

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-60761-594-1_20

    DOI

    http://dx.doi.org/10.1007/978-1-60761-594-1_20

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045147790

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20094873


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