Radiation Therapy: Adjuvant vs. Neoadjuvant Therapy View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2010-06-29

AUTHORS

Rolf Sauer , Claus Rödel

ABSTRACT

Historically, combined chemoradiotherapy has been shown to improve local control and overall survival rates compared to surgery alone in the adjuvant setting. The primary advantage of an adjuvant approach is improved patient selection based on operative and pathologic staging. Comparatively, a neoadjuvant approach decreases rates of acute and chronic toxicity, facilitates tumor downing staging in patients who might otherwise require abdominoperineal resection, and improves local control rates. This has been confirmed by recent randomized studies which demonstrated improved disease- and treatment-related outcomes using a neoadjuvant vs. adjuvant approach. Presently, ongoing studies are evaluating the integration of novel systemic agents in combination with radiation therapy in the neoadjuvant setting. More... »

PAGES

223-234

Book

TITLE

Rectal Cancer

ISBN

978-1-60761-566-8
978-1-60761-567-5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-60761-567-5_13

DOI

http://dx.doi.org/10.1007/978-1-60761-567-5_13

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017199404


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