CNS Delivery of Peptides Across the BBB Using the Dual-Artery In Situ Brain Perfusion Model View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2009-11-25

AUTHORS

Ken A. Witt , Patrick T. Ronaldson , Karin E. Sandoval , Thomas P. Davis

ABSTRACT

Peptides have been shown to be potent regulators of central nervous system (CNS) activity. As such, peptide-based drugs can serve as a highly effective means to treat diseases of the CNS. Despite this potential, peptides have limited capacity to permeate across the blood–brain barrier (BBB). Nevertheless, advancing strategies in peptide drug design, delivery systems, and transporter targeting are emerging, with such potential to overcome the restrictive nature of the BBB. This chapter addresses peptide drug delivery into the CNS, and in vivo evaluation of peptide permeability across the BBB using the dual-artery in situ brain perfusion model coupled with the technique of capillary depletion. More... »

PAGES

233-247

References to SciGraph publications

Book

TITLE

Drug Delivery to the Central Nervous System

ISBN

978-1-60761-528-6
978-1-60761-529-3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-60761-529-3_11

DOI

http://dx.doi.org/10.1007/978-1-60761-529-3_11

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018121036


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