IgE Interacts with Potent Effector Cells Against Tumors: ADCC and ADCP View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2009-10-30

AUTHORS

Sophia N. Karagiannis , Frank O. Nestle , Hannah J. Gould

ABSTRACT

We examine the properties of IgE antibodies which may render them effective against tumors. This may be due to the uniquely high affinity of IgE antibodies for their Fc epsilon (Fcɛ) receptors and the expression of IgE antibodies on potent effector cells. Owing to these properties, IgE antibodies activate effector cell mechanisms that may be different from and stronger than those mediated by antibodies of other classes, thereby inducing superior anti-tumor responses. In examining the potential of IgE–FcɛRI complexes on effector cells to activate effector cells (and describe evidence to-date) we suggest that the interactions of IgE antibodies with tumor-associated antigens on tumor cells and Fc receptors on IgE receptor-bearing cells trigger the association of tumor and effector cells. The outcome of these interactions is effector cell activation and effective tumor cell death by a number of mechanisms including antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). More... »

PAGES

185-213

Book

TITLE

Cancer and IgE

ISBN

978-1-60761-450-0
978-1-60761-451-7

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-60761-451-7_8

DOI

http://dx.doi.org/10.1007/978-1-60761-451-7_8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034137719


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