A Systematic Strategy for the Discovery of Candidate Genes Responsible for Phenotypic Variation View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2009-07-27

AUTHORS

Paul Fisher , Harry Noyes , Stephen Kemp , Robert Stevens , Andrew Brass

ABSTRACT

It is increasingly common to combine genome-wide expression data with quantitative trait mapping data to aid in the search for sequence polymorphisms responsible for phenotypic variation. By joining these complex but different data types at the level of the biological pathway, we can take advantage of existing biological knowledge to systematically identify possible mechanisms of genotype–phenotype interaction. With the development of web services and workflows, this process can be made rapid and systematic. Our methodology was applied to a use case of resistance to African trypanosomiasis in mice. Workflows developed in this investigation, including a guide to loading and executing them with example data, are available at http://www.myexperiment.org/users/43/workflows. More... »

PAGES

329-345

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-60761-247-6_18

DOI

http://dx.doi.org/10.1007/978-1-60761-247-6_18

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045774117

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19763936


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