Meningiomas View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2010-11-20

AUTHORS

Marc C. Chamberlain

ABSTRACT

Meningiomas are extra-axial central nervous system (CNS) tumors most often discovered in middle-to-late adult life and which have a female predominance; 95% of meningiomas are benign, 6–8% atypical, and 1–2% are malignant. The majority of patients diagnosed with a symptomatic meningioma undergo surgical resection to relieve neurological symptoms. Complete surgical resection may be curative. For incompletely resected or recurrent tumors not previously irradiated, radiotherapy is administered. Radiotherapy may be administered as either conventional external beam irradiation or stereotactically by linear accelerator (LINAC), Leksell Gamma Knife™, or Cyberknife™ radiosurgery. Advocates of stereotactic radiotherapy have suggested this therapy in lieu of surgery particularly in poor surgical risk patients, patients with meningiomas in eloquent or surgically inaccessible locations, and in patients of advanced age. In the subpopulation of patients with an unresectable tumor and refractory to radiotherapy, hormonal-chemotherapy-targeted therapy is often prescribed. Notwithstanding limited data, hydroxyurea has been modestly successful in patients with recurrent meningiomas. Emerging targeted therapies may prove useful in refractory meningiomas as recently demonstrated with α-interferon and somatostatin analogs. More... »

PAGES

355-375

Book

TITLE

Primary Central Nervous System Tumors

ISBN

978-1-60761-165-3
978-1-60761-166-0

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-60761-166-0_15

DOI

http://dx.doi.org/10.1007/978-1-60761-166-0_15

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024555183


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