Iron and the Immune System View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2011-11-24

AUTHORS

Hal Drakesmith , Graça Porto , Maria de Sousa

ABSTRACT

Metchnikoff shared the Nobel Prize with Paul Ehrlich ‘in recognition of their work in Immunity’. The concept of immunity had preceded by just over 100 years [1], the dim beginning of the realization that some cells could respond to the challenge by foreign bodies clustering round them and phagocytosing them. Macrophages and Ilya Metchnikoff can thus be viewed as pioneers of what we know today to be the immune system. In general, Nobel Prizes in Physiology and Medicine have distinguished immunologists for ‘the practical value of pure research’, particularly in infection. This chapter will not go against that tradition. Several recent pieces of work, however, point to the fact that the immune system cells are equipped with iron proteins that may have regulatory functions of iron metabolism. The practical value to immunity of such novel functions cannot be disputed. But in a chapter of a book prepared at the beginning of a new century, their possible physiological significance should not be ignored. More... »

PAGES

233-248

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-60327-485-2_12

DOI

http://dx.doi.org/10.1007/978-1-60327-485-2_12

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053449536


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Molecular Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, OX3 9DS, Oxford, UK", 
          "id": "http://www.grid.ac/institutes/grid.8348.7", 
          "name": [
            "Molecular Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, OX3 9DS, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Drakesmith", 
        "givenName": "Hal", 
        "id": "sg:person.01073114534.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073114534.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GABBA Program/ICBAS, IBMC, Molecular and Cellular Biology Institute, University of Porto, 4150-180, Porto, Portugal", 
          "id": "http://www.grid.ac/institutes/grid.5808.5", 
          "name": [
            "GABBA Program/ICBAS, IBMC, Molecular and Cellular Biology Institute, University of Porto, 4150-180, Porto, Portugal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Porto", 
        "givenName": "Gra\u00e7a", 
        "id": "sg:person.01300175764.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300175764.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GABBA Program/ICBAS, IBMC, Molecular and Cellular Biology Institute, University of Porto, 4150-180, Porto, Portugal", 
          "id": "http://www.grid.ac/institutes/grid.5808.5", 
          "name": [
            "GABBA Program/ICBAS, IBMC, Molecular and Cellular Biology Institute, University of Porto, 4150-180, Porto, Portugal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Sousa", 
        "givenName": "Maria", 
        "id": "sg:person.01067012756.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067012756.16"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2011-11-24", 
    "datePublishedReg": "2011-11-24", 
    "description": "Metchnikoff shared the Nobel Prize with Paul Ehrlich \u2018in recognition of their work in Immunity\u2019. The concept of immunity had preceded by just over 100 years [1], the dim beginning of the realization that some cells could respond to the challenge by foreign bodies clustering round them and phagocytosing them. Macrophages and Ilya Metchnikoff can thus be viewed as pioneers of what we know today to be the immune system. In general, Nobel Prizes in Physiology and Medicine have distinguished immunologists for \u2018the practical value of pure research\u2019, particularly in infection. This chapter will not go against that tradition. Several recent pieces of work, however, point to the fact that the immune system cells are equipped with iron proteins that may have regulatory functions of iron metabolism. The practical value to immunity of such novel functions cannot be disputed. But in a chapter of a book prepared at the beginning of a new century, their possible physiological significance should not be ignored.", 
    "editor": [
      {
        "familyName": "Anderson", 
        "givenName": "Gregory J.", 
        "type": "Person"
      }, 
      {
        "familyName": "McLaren", 
        "givenName": "Gordon D.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-60327-485-2_12", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-60327-484-5", 
        "978-1-60327-485-2"
      ], 
      "name": "Iron Physiology and Pathophysiology in Humans", 
      "type": "Book"
    }, 
    "keywords": [
      "immune system", 
      "immune system cells", 
      "foreign body", 
      "system cells", 
      "iron metabolism", 
      "immunity", 
      "Paul Ehrlich", 
      "possible physiological significance", 
      "physiological significance", 
      "cells", 
      "regulatory functions", 
      "Metchnikoff", 
      "infection", 
      "novel function", 
      "macrophages", 
      "concept of immunity", 
      "immunologists", 
      "metabolism", 
      "Ehrlich", 
      "medicine", 
      "years", 
      "physiology", 
      "function", 
      "Ilya Metchnikoff", 
      "significance", 
      "recent piece", 
      "protein", 
      "body", 
      "beginning", 
      "values", 
      "Nobel Prize", 
      "challenges", 
      "recognition", 
      "chapter", 
      "system", 
      "research", 
      "practical value", 
      "iron", 
      "point", 
      "fact", 
      "iron protein", 
      "such novel functions", 
      "pure research", 
      "work", 
      "pieces", 
      "new century", 
      "today", 
      "Prize", 
      "concept", 
      "pioneers", 
      "century", 
      "book", 
      "tradition", 
      "realization", 
      "dim beginning"
    ], 
    "name": "Iron and the Immune System", 
    "pagination": "233-248", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1053449536"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-60327-485-2_12"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-60327-485-2_12", 
      "https://app.dimensions.ai/details/publication/pub.1053449536"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-01-01T19:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/chapter/chapter_218.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-1-60327-485-2_12"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-60327-485-2_12'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-60327-485-2_12'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-60327-485-2_12'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-60327-485-2_12'


 

This table displays all metadata directly associated to this object as RDF triples.

137 TRIPLES      23 PREDICATES      79 URIs      72 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-60327-485-2_12 schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author N244c10af753f4109bb346751a2e697d3
4 schema:datePublished 2011-11-24
5 schema:datePublishedReg 2011-11-24
6 schema:description Metchnikoff shared the Nobel Prize with Paul Ehrlich ‘in recognition of their work in Immunity’. The concept of immunity had preceded by just over 100 years [1], the dim beginning of the realization that some cells could respond to the challenge by foreign bodies clustering round them and phagocytosing them. Macrophages and Ilya Metchnikoff can thus be viewed as pioneers of what we know today to be the immune system. In general, Nobel Prizes in Physiology and Medicine have distinguished immunologists for ‘the practical value of pure research’, particularly in infection. This chapter will not go against that tradition. Several recent pieces of work, however, point to the fact that the immune system cells are equipped with iron proteins that may have regulatory functions of iron metabolism. The practical value to immunity of such novel functions cannot be disputed. But in a chapter of a book prepared at the beginning of a new century, their possible physiological significance should not be ignored.
7 schema:editor Naa62feafcdb04299966bf35544486c2f
8 schema:genre chapter
9 schema:inLanguage en
10 schema:isAccessibleForFree false
11 schema:isPartOf N6dd1493cefda4c0789618967a1935745
12 schema:keywords Ehrlich
13 Ilya Metchnikoff
14 Metchnikoff
15 Nobel Prize
16 Paul Ehrlich
17 Prize
18 beginning
19 body
20 book
21 cells
22 century
23 challenges
24 chapter
25 concept
26 concept of immunity
27 dim beginning
28 fact
29 foreign body
30 function
31 immune system
32 immune system cells
33 immunity
34 immunologists
35 infection
36 iron
37 iron metabolism
38 iron protein
39 macrophages
40 medicine
41 metabolism
42 new century
43 novel function
44 physiological significance
45 physiology
46 pieces
47 pioneers
48 point
49 possible physiological significance
50 practical value
51 protein
52 pure research
53 realization
54 recent piece
55 recognition
56 regulatory functions
57 research
58 significance
59 such novel functions
60 system
61 system cells
62 today
63 tradition
64 values
65 work
66 years
67 schema:name Iron and the Immune System
68 schema:pagination 233-248
69 schema:productId Nb4cd104b23684c82ab38026a204fc1ab
70 Ncbef8eb6a3664ec3823ef333713766ec
71 schema:publisher N264a830a0f2f439eaf2df1ed5596cc1b
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053449536
73 https://doi.org/10.1007/978-1-60327-485-2_12
74 schema:sdDatePublished 2022-01-01T19:12
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher N03be57337dc84e50827ec1d11e3751de
77 schema:url https://doi.org/10.1007/978-1-60327-485-2_12
78 sgo:license sg:explorer/license/
79 sgo:sdDataset chapters
80 rdf:type schema:Chapter
81 N03be57337dc84e50827ec1d11e3751de schema:name Springer Nature - SN SciGraph project
82 rdf:type schema:Organization
83 N1f0c568e598745918c412ccf92b0a00f rdf:first sg:person.01067012756.16
84 rdf:rest rdf:nil
85 N244c10af753f4109bb346751a2e697d3 rdf:first sg:person.01073114534.66
86 rdf:rest N6df3424028fa467fa47d5ab2f65daaf2
87 N264a830a0f2f439eaf2df1ed5596cc1b schema:name Springer Nature
88 rdf:type schema:Organisation
89 N6dd1493cefda4c0789618967a1935745 schema:isbn 978-1-60327-484-5
90 978-1-60327-485-2
91 schema:name Iron Physiology and Pathophysiology in Humans
92 rdf:type schema:Book
93 N6df3424028fa467fa47d5ab2f65daaf2 rdf:first sg:person.01300175764.00
94 rdf:rest N1f0c568e598745918c412ccf92b0a00f
95 N771a8a61fb6f48d697245553cef78912 schema:familyName McLaren
96 schema:givenName Gordon D.
97 rdf:type schema:Person
98 N8c7cd6c2636c44a5b47e71cd8d75f60c schema:familyName Anderson
99 schema:givenName Gregory J.
100 rdf:type schema:Person
101 Naa62feafcdb04299966bf35544486c2f rdf:first N8c7cd6c2636c44a5b47e71cd8d75f60c
102 rdf:rest Naa7ab22ddd984d449c204dac079007a0
103 Naa7ab22ddd984d449c204dac079007a0 rdf:first N771a8a61fb6f48d697245553cef78912
104 rdf:rest rdf:nil
105 Nb4cd104b23684c82ab38026a204fc1ab schema:name doi
106 schema:value 10.1007/978-1-60327-485-2_12
107 rdf:type schema:PropertyValue
108 Ncbef8eb6a3664ec3823ef333713766ec schema:name dimensions_id
109 schema:value pub.1053449536
110 rdf:type schema:PropertyValue
111 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
112 schema:name Medical and Health Sciences
113 rdf:type schema:DefinedTerm
114 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
115 schema:name Immunology
116 rdf:type schema:DefinedTerm
117 sg:person.01067012756.16 schema:affiliation grid-institutes:grid.5808.5
118 schema:familyName de Sousa
119 schema:givenName Maria
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067012756.16
121 rdf:type schema:Person
122 sg:person.01073114534.66 schema:affiliation grid-institutes:grid.8348.7
123 schema:familyName Drakesmith
124 schema:givenName Hal
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073114534.66
126 rdf:type schema:Person
127 sg:person.01300175764.00 schema:affiliation grid-institutes:grid.5808.5
128 schema:familyName Porto
129 schema:givenName Graça
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300175764.00
131 rdf:type schema:Person
132 grid-institutes:grid.5808.5 schema:alternateName GABBA Program/ICBAS, IBMC, Molecular and Cellular Biology Institute, University of Porto, 4150-180, Porto, Portugal
133 schema:name GABBA Program/ICBAS, IBMC, Molecular and Cellular Biology Institute, University of Porto, 4150-180, Porto, Portugal
134 rdf:type schema:Organization
135 grid-institutes:grid.8348.7 schema:alternateName Molecular Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, OX3 9DS, Oxford, UK
136 schema:name Molecular Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, OX3 9DS, Oxford, UK
137 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...