Generation of Gene-Specific Mutated Rats Using Zinc-Finger Nucleases View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2009-10-28

AUTHORS

Aron M. Geurts , Gregory J. Cost , Séverine Rémy , Xiaoxia Cui , Laurent Tesson , Claire Usal , Séverine Ménoret , Howard J. Jacob , Ignacio Anegon , Roland Buelow

ABSTRACT

The genetic dissection of physiological and pathological traits in laboratory model organisms is accelerated by the ability to engineer loss-of-function mutations at investigator-specified loci. This chapter describes the use of zinc-finger nucleases (ZFNs) for the targeted disruption of endogenous rat genes directly in the embryo. ZFNs can specifically disrupt target genes in cultured rat cells and in embryos from inbred and outbred strains, leading to permanently genetically modified animals. This technology allows for the rapid, targeted modification of the rat genome. More... »

PAGES

211-225

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-60327-389-3_15

DOI

http://dx.doi.org/10.1007/978-1-60327-389-3_15

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015950599

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20013236


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