GPCR Signaling: Understanding the Pathway to Successful Drug Discovery View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2009-04-30

AUTHORS

Christine Williams , Stephen J. Hill

ABSTRACT

Modulators of G protein-coupled receptors (GPCRs) form a key area for the pharmaceutical industry, representing ˜27% of all Food and Drug Administration (FDA)-approved drugs. Consequently, there are a wide variety of in vitro plate-based screening technologies that enable the measurement of compound affinity, potency, and efficacy for almost every type of GPCR. However, to maximize success it is prudent to ensure that (i) the most suitable assay formats are identified, (ii) they are configured optimally to detect the desired compound activity, and (iii) that they form a basis for predicting clinical effects. To achieve this, an understanding of the pathways and mechanisms of receptor activation relevant to the disease mechanism, as well as the benefits and/or limitations of the specific techniques, is key. More... »

PAGES

39-50

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-60327-317-6_3

DOI

http://dx.doi.org/10.1007/978-1-60327-317-6_3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051997479

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19513640


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0399", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Other Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combinatorial Chemistry Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Discovery", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, G-Protein-Coupled", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Director HTS CoE, Pfizer Global Research and Development, Sandwich, Kent, UK", 
          "id": "http://www.grid.ac/institutes/grid.418566.8", 
          "name": [
            "Director HTS CoE, Pfizer Global Research and Development, Sandwich, Kent, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Williams", 
        "givenName": "Christine", 
        "id": "sg:person.0755070252.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755070252.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cell Signalling, Queen\u2019s Medical Centre, Nottingham, UK", 
          "id": "http://www.grid.ac/institutes/grid.415598.4", 
          "name": [
            "Institute of Cell Signalling, Queen\u2019s Medical Centre, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hill", 
        "givenName": "Stephen J.", 
        "id": "sg:person.01034573516.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034573516.52"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2009-04-30", 
    "datePublishedReg": "2009-04-30", 
    "description": "Modulators of G protein-coupled receptors (GPCRs) form a key area for the pharmaceutical industry, representing \u02dc27% of all Food and Drug Administration (FDA)-approved drugs. Consequently, there are a wide variety of in vitro plate-based screening technologies that enable the measurement of compound affinity, potency, and efficacy for almost every type of GPCR. However, to maximize success it is prudent to ensure that (i) the most suitable assay formats are identified, (ii) they are configured optimally to detect the desired compound activity, and (iii) that they form a basis for predicting clinical effects. To achieve this, an understanding of the pathways and mechanisms of receptor activation relevant to the disease mechanism, as well as the benefits and/or limitations of the specific techniques, is key.", 
    "editor": [
      {
        "familyName": "Leifert", 
        "givenName": "Wayne R.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-60327-317-6_3", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-60327-316-9", 
        "978-1-60327-317-6"
      ], 
      "name": "G Protein-Coupled Receptors in Drug Discovery", 
      "type": "Book"
    }, 
    "keywords": [
      "suitable assay formats", 
      "protein-coupled receptors", 
      "clinical effects", 
      "types of GPCRs", 
      "Drug Administration", 
      "receptor activation", 
      "disease mechanisms", 
      "successful drug discovery", 
      "GPCRs", 
      "compound activity", 
      "drug discovery", 
      "pathway", 
      "administration", 
      "receptors", 
      "drugs", 
      "screening technologies", 
      "efficacy", 
      "specific techniques", 
      "potency", 
      "activation", 
      "assay formats", 
      "mechanism", 
      "pharmaceutical industry", 
      "compound affinity", 
      "modulator", 
      "food", 
      "key areas", 
      "activity", 
      "wide variety", 
      "benefits", 
      "effect", 
      "affinity", 
      "types", 
      "success", 
      "discovery", 
      "area", 
      "variety", 
      "understanding", 
      "limitations", 
      "basis", 
      "technique", 
      "measurements", 
      "format", 
      "technology", 
      "industry", 
      "plate-based screening technologies"
    ], 
    "name": "GPCR Signaling: Understanding the Pathway to Successful Drug Discovery", 
    "pagination": "39-50", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1051997479"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-60327-317-6_3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19513640"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-60327-317-6_3", 
      "https://app.dimensions.ai/details/publication/pub.1051997479"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-01-01T19:26", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/chapter/chapter_55.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-1-60327-317-6_3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-60327-317-6_3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-60327-317-6_3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-60327-317-6_3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-60327-317-6_3'


 

This table displays all metadata directly associated to this object as RDF triples.

152 TRIPLES      23 PREDICATES      80 URIs      71 LITERALS      14 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-60327-317-6_3 schema:about N692f692002c64cee88735ecf166beca7
2 N6cb64409008241dabdbab75921b192eb
3 N9c2ec324791b4725897e6709ff437cb4
4 Nd2ba35889ba44812a1afb5889ecb8443
5 Ndce60855eef04532bd62c87d840f89e5
6 Nff0fea36d43043a3987305389684d78f
7 anzsrc-for:03
8 anzsrc-for:0399
9 anzsrc-for:06
10 anzsrc-for:0601
11 schema:author N64363adafe924345bf4db71708639edd
12 schema:datePublished 2009-04-30
13 schema:datePublishedReg 2009-04-30
14 schema:description Modulators of G protein-coupled receptors (GPCRs) form a key area for the pharmaceutical industry, representing ˜27% of all Food and Drug Administration (FDA)-approved drugs. Consequently, there are a wide variety of in vitro plate-based screening technologies that enable the measurement of compound affinity, potency, and efficacy for almost every type of GPCR. However, to maximize success it is prudent to ensure that (i) the most suitable assay formats are identified, (ii) they are configured optimally to detect the desired compound activity, and (iii) that they form a basis for predicting clinical effects. To achieve this, an understanding of the pathways and mechanisms of receptor activation relevant to the disease mechanism, as well as the benefits and/or limitations of the specific techniques, is key.
15 schema:editor Nd03668bf71024dc3a0b2fae731dc9b37
16 schema:genre chapter
17 schema:inLanguage en
18 schema:isAccessibleForFree false
19 schema:isPartOf Ne542c4e809014e249ed906bd0f4c0427
20 schema:keywords Drug Administration
21 GPCRs
22 activation
23 activity
24 administration
25 affinity
26 area
27 assay formats
28 basis
29 benefits
30 clinical effects
31 compound activity
32 compound affinity
33 discovery
34 disease mechanisms
35 drug discovery
36 drugs
37 effect
38 efficacy
39 food
40 format
41 industry
42 key areas
43 limitations
44 measurements
45 mechanism
46 modulator
47 pathway
48 pharmaceutical industry
49 plate-based screening technologies
50 potency
51 protein-coupled receptors
52 receptor activation
53 receptors
54 screening technologies
55 specific techniques
56 success
57 successful drug discovery
58 suitable assay formats
59 technique
60 technology
61 types
62 types of GPCRs
63 understanding
64 variety
65 wide variety
66 schema:name GPCR Signaling: Understanding the Pathway to Successful Drug Discovery
67 schema:pagination 39-50
68 schema:productId N7191e0f610174fa9a1ec11689140c4d1
69 Na5435ac587274066aa454f72a5725307
70 Nd5530371e7f148c6a83dc99263c6a95e
71 schema:publisher N384d0f8f651c4816b55a76f7c3f100e6
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051997479
73 https://doi.org/10.1007/978-1-60327-317-6_3
74 schema:sdDatePublished 2022-01-01T19:26
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher N9b6c8bb17461463290574dae34158c55
77 schema:url https://doi.org/10.1007/978-1-60327-317-6_3
78 sgo:license sg:explorer/license/
79 sgo:sdDataset chapters
80 rdf:type schema:Chapter
81 N384d0f8f651c4816b55a76f7c3f100e6 schema:name Springer Nature
82 rdf:type schema:Organisation
83 N64363adafe924345bf4db71708639edd rdf:first sg:person.0755070252.32
84 rdf:rest Nf469bf88549d42e1af1c852a13435af5
85 N692f692002c64cee88735ecf166beca7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Combinatorial Chemistry Techniques
87 rdf:type schema:DefinedTerm
88 N6cb64409008241dabdbab75921b192eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Animals
90 rdf:type schema:DefinedTerm
91 N7191e0f610174fa9a1ec11689140c4d1 schema:name pubmed_id
92 schema:value 19513640
93 rdf:type schema:PropertyValue
94 N9b6c8bb17461463290574dae34158c55 schema:name Springer Nature - SN SciGraph project
95 rdf:type schema:Organization
96 N9c2ec324791b4725897e6709ff437cb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Humans
98 rdf:type schema:DefinedTerm
99 Na0d2a7fa958745c7b3c31082b4386a25 schema:familyName Leifert
100 schema:givenName Wayne R.
101 rdf:type schema:Person
102 Na5435ac587274066aa454f72a5725307 schema:name doi
103 schema:value 10.1007/978-1-60327-317-6_3
104 rdf:type schema:PropertyValue
105 Nd03668bf71024dc3a0b2fae731dc9b37 rdf:first Na0d2a7fa958745c7b3c31082b4386a25
106 rdf:rest rdf:nil
107 Nd2ba35889ba44812a1afb5889ecb8443 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Receptors, G-Protein-Coupled
109 rdf:type schema:DefinedTerm
110 Nd5530371e7f148c6a83dc99263c6a95e schema:name dimensions_id
111 schema:value pub.1051997479
112 rdf:type schema:PropertyValue
113 Ndce60855eef04532bd62c87d840f89e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Signal Transduction
115 rdf:type schema:DefinedTerm
116 Ne542c4e809014e249ed906bd0f4c0427 schema:isbn 978-1-60327-316-9
117 978-1-60327-317-6
118 schema:name G Protein-Coupled Receptors in Drug Discovery
119 rdf:type schema:Book
120 Nf469bf88549d42e1af1c852a13435af5 rdf:first sg:person.01034573516.52
121 rdf:rest rdf:nil
122 Nff0fea36d43043a3987305389684d78f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Drug Discovery
124 rdf:type schema:DefinedTerm
125 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
126 schema:name Chemical Sciences
127 rdf:type schema:DefinedTerm
128 anzsrc-for:0399 schema:inDefinedTermSet anzsrc-for:
129 schema:name Other Chemical Sciences
130 rdf:type schema:DefinedTerm
131 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
132 schema:name Biological Sciences
133 rdf:type schema:DefinedTerm
134 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
135 schema:name Biochemistry and Cell Biology
136 rdf:type schema:DefinedTerm
137 sg:person.01034573516.52 schema:affiliation grid-institutes:grid.415598.4
138 schema:familyName Hill
139 schema:givenName Stephen J.
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034573516.52
141 rdf:type schema:Person
142 sg:person.0755070252.32 schema:affiliation grid-institutes:grid.418566.8
143 schema:familyName Williams
144 schema:givenName Christine
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755070252.32
146 rdf:type schema:Person
147 grid-institutes:grid.415598.4 schema:alternateName Institute of Cell Signalling, Queen’s Medical Centre, Nottingham, UK
148 schema:name Institute of Cell Signalling, Queen’s Medical Centre, Nottingham, UK
149 rdf:type schema:Organization
150 grid-institutes:grid.418566.8 schema:alternateName Director HTS CoE, Pfizer Global Research and Development, Sandwich, Kent, UK
151 schema:name Director HTS CoE, Pfizer Global Research and Development, Sandwich, Kent, UK
152 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...