The Anti-cancer Effect of Vitamin D: What Do the Randomized Trials Show? View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2010-02-24

AUTHORS

Joan M. Lappe , Robert P. Heaney

ABSTRACT

One of the most exciting roles of vitamin D is its potential for preventing or slowing the development of cancer. The inverse association between sunlight exposure and malignancy has been recognized for decades, and numerous epidemiological studies support the inverse association of cancer and vitamin D. In vitro and in vivo studies have provided understanding of an underlying mechanism for the vitamin D effect. However, recently there has been increased intensity in vitamin D/cancer research after publication of a randomized trial that found that vitamin D3 and calcium reduced the risk of all-type cancer by 60–77%. The only other randomized trial had conflicting results. In this chapter, we evaluate the strength of those randomized trials and the associated hypothesis that adequate vitamin D status reduces incident cancer rate. We also describe present estimates of serum 25-hydroxyvitamin D [25(OH)D] needed to prevent cancer and propose doses of vitamin D3 supplementation needed to maintain those 25(OH)D levels. More... »

PAGES

841-850

Book

TITLE

Vitamin D

ISBN

978-1-60327-300-8
978-1-60327-303-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-60327-303-9_45

DOI

http://dx.doi.org/10.1007/978-1-60327-303-9_45

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031276252


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Creighton University, 68131, Omaha, NE, USA", 
          "id": "http://www.grid.ac/institutes/grid.254748.8", 
          "name": [
            "Creighton University, 68131, Omaha, NE, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lappe", 
        "givenName": "Joan M.", 
        "id": "sg:person.0714345342.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714345342.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Creighton University, 68131, Omaha, NE, USA", 
          "id": "http://www.grid.ac/institutes/grid.254748.8", 
          "name": [
            "Creighton University, 68131, Omaha, NE, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heaney", 
        "givenName": "Robert P.", 
        "id": "sg:person.0645437522.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645437522.96"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2010-02-24", 
    "datePublishedReg": "2010-02-24", 
    "description": "One of the most exciting roles of vitamin D is its potential for preventing or slowing the development of cancer. The inverse association between sunlight exposure and malignancy has been recognized for decades, and numerous epidemiological studies support the inverse association of cancer and vitamin D. In vitro and in vivo studies have provided understanding of an underlying mechanism for the vitamin D effect. However, recently there has been increased intensity in vitamin D/cancer research after publication of a randomized trial that found that vitamin D3 and calcium reduced the risk of all-type cancer by 60\u201377%. The only other randomized trial had conflicting results. In this chapter, we evaluate the strength of those randomized trials and the associated hypothesis that adequate vitamin D status reduces incident cancer rate. We also describe present estimates of serum 25-hydroxyvitamin D [25(OH)D] needed to prevent cancer and propose doses of vitamin D3 supplementation needed to maintain those 25(OH)D levels.", 
    "editor": [
      {
        "familyName": "Holick", 
        "givenName": "Michael F.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-60327-303-9_45", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-60327-300-8", 
        "978-1-60327-303-9"
      ], 
      "name": "Vitamin D", 
      "type": "Book"
    }, 
    "keywords": [
      "vitamin D", 
      "inverse association", 
      "adequate vitamin D status", 
      "incident cancer rates", 
      "vitamin D3 supplementation", 
      "vitamin D status", 
      "vitamin D effects", 
      "Numerous epidemiological studies", 
      "anti-cancer effects", 
      "development of cancer", 
      "D status", 
      "D3 supplementation", 
      "vitamin D.", 
      "type cancer", 
      "vitamin D3", 
      "cancer rates", 
      "epidemiological studies", 
      "trial show", 
      "cancer", 
      "vivo studies", 
      "conflicting results", 
      "sunlight exposure", 
      "trials", 
      "underlying mechanism", 
      "D effects", 
      "cancer research", 
      "association", 
      "exciting role", 
      "malignancy", 
      "doses", 
      "supplementation", 
      "D3", 
      "risk", 
      "vitro", 
      "study", 
      "exposure", 
      "calcium", 
      "status", 
      "effect", 
      "D.", 
      "levels", 
      "role", 
      "rate", 
      "hypothesis", 
      "mechanism", 
      "publications", 
      "development", 
      "potential", 
      "decades", 
      "results", 
      "understanding", 
      "intensity", 
      "research", 
      "estimates", 
      "present estimates", 
      "chapter", 
      "associated hypotheses", 
      "show", 
      "strength"
    ], 
    "name": "The Anti-cancer Effect of Vitamin D: What Do the Randomized Trials Show?", 
    "pagination": "841-850", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031276252"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-60327-303-9_45"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-60327-303-9_45", 
      "https://app.dimensions.ai/details/publication/pub.1031276252"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-08-04T17:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/chapter/chapter_384.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-1-60327-303-9_45"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-60327-303-9_45'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-60327-303-9_45'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-60327-303-9_45'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-60327-303-9_45'


 

This table displays all metadata directly associated to this object as RDF triples.

125 TRIPLES      22 PREDICATES      82 URIs      75 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-60327-303-9_45 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N0ba892086f09402a95050aa75706df81
4 schema:datePublished 2010-02-24
5 schema:datePublishedReg 2010-02-24
6 schema:description One of the most exciting roles of vitamin D is its potential for preventing or slowing the development of cancer. The inverse association between sunlight exposure and malignancy has been recognized for decades, and numerous epidemiological studies support the inverse association of cancer and vitamin D. In vitro and in vivo studies have provided understanding of an underlying mechanism for the vitamin D effect. However, recently there has been increased intensity in vitamin D/cancer research after publication of a randomized trial that found that vitamin D3 and calcium reduced the risk of all-type cancer by 60–77%. The only other randomized trial had conflicting results. In this chapter, we evaluate the strength of those randomized trials and the associated hypothesis that adequate vitamin D status reduces incident cancer rate. We also describe present estimates of serum 25-hydroxyvitamin D [25(OH)D] needed to prevent cancer and propose doses of vitamin D3 supplementation needed to maintain those 25(OH)D levels.
7 schema:editor N12f7609ef5434893a3d3c371669198b7
8 schema:genre chapter
9 schema:isAccessibleForFree false
10 schema:isPartOf Ne28d61c4ab944c25a430f3f88cf112cd
11 schema:keywords D effects
12 D status
13 D.
14 D3
15 D3 supplementation
16 Numerous epidemiological studies
17 adequate vitamin D status
18 anti-cancer effects
19 associated hypotheses
20 association
21 calcium
22 cancer
23 cancer rates
24 cancer research
25 chapter
26 conflicting results
27 decades
28 development
29 development of cancer
30 doses
31 effect
32 epidemiological studies
33 estimates
34 exciting role
35 exposure
36 hypothesis
37 incident cancer rates
38 intensity
39 inverse association
40 levels
41 malignancy
42 mechanism
43 potential
44 present estimates
45 publications
46 rate
47 research
48 results
49 risk
50 role
51 show
52 status
53 strength
54 study
55 sunlight exposure
56 supplementation
57 trial show
58 trials
59 type cancer
60 underlying mechanism
61 understanding
62 vitamin D
63 vitamin D effects
64 vitamin D status
65 vitamin D.
66 vitamin D3
67 vitamin D3 supplementation
68 vitro
69 vivo studies
70 schema:name The Anti-cancer Effect of Vitamin D: What Do the Randomized Trials Show?
71 schema:pagination 841-850
72 schema:productId N647ba257536648c7bbd18c3427ced6ee
73 Nf924eac1cd284eb18dba8cb9d4a12155
74 schema:publisher Na5f080da02934039af62246adad23c8f
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031276252
76 https://doi.org/10.1007/978-1-60327-303-9_45
77 schema:sdDatePublished 2022-08-04T17:20
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher Nfb6328fab45948a9ba451c9c75567c59
80 schema:url https://doi.org/10.1007/978-1-60327-303-9_45
81 sgo:license sg:explorer/license/
82 sgo:sdDataset chapters
83 rdf:type schema:Chapter
84 N0ba892086f09402a95050aa75706df81 rdf:first sg:person.0714345342.23
85 rdf:rest N41b4b068e679453493bedb1a08ea771b
86 N12f7609ef5434893a3d3c371669198b7 rdf:first N166bcdb6f4fd442c80ad0d5ce4d0cadc
87 rdf:rest rdf:nil
88 N166bcdb6f4fd442c80ad0d5ce4d0cadc schema:familyName Holick
89 schema:givenName Michael F.
90 rdf:type schema:Person
91 N41b4b068e679453493bedb1a08ea771b rdf:first sg:person.0645437522.96
92 rdf:rest rdf:nil
93 N647ba257536648c7bbd18c3427ced6ee schema:name doi
94 schema:value 10.1007/978-1-60327-303-9_45
95 rdf:type schema:PropertyValue
96 Na5f080da02934039af62246adad23c8f schema:name Springer Nature
97 rdf:type schema:Organisation
98 Ne28d61c4ab944c25a430f3f88cf112cd schema:isbn 978-1-60327-300-8
99 978-1-60327-303-9
100 schema:name Vitamin D
101 rdf:type schema:Book
102 Nf924eac1cd284eb18dba8cb9d4a12155 schema:name dimensions_id
103 schema:value pub.1031276252
104 rdf:type schema:PropertyValue
105 Nfb6328fab45948a9ba451c9c75567c59 schema:name Springer Nature - SN SciGraph project
106 rdf:type schema:Organization
107 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
108 schema:name Medical and Health Sciences
109 rdf:type schema:DefinedTerm
110 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
111 schema:name Oncology and Carcinogenesis
112 rdf:type schema:DefinedTerm
113 sg:person.0645437522.96 schema:affiliation grid-institutes:grid.254748.8
114 schema:familyName Heaney
115 schema:givenName Robert P.
116 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645437522.96
117 rdf:type schema:Person
118 sg:person.0714345342.23 schema:affiliation grid-institutes:grid.254748.8
119 schema:familyName Lappe
120 schema:givenName Joan M.
121 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714345342.23
122 rdf:type schema:Person
123 grid-institutes:grid.254748.8 schema:alternateName Creighton University, 68131, Omaha, NE, USA
124 schema:name Creighton University, 68131, Omaha, NE, USA
125 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...