Membranoproliferative or Mesangiocapillary Glomulonephritis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2008

AUTHORS

Montserrat M. Díaz , Laia Sans , Yolanda Arce , José Ballarin

ABSTRACT

Membranoproliferative glomerulonephritis (MPGN), also called mesangiocapillary glomerulonephritis, is a complex and uncommon cause of glomerular disease. Its name describes the most relevant histological characteristics of this entity: thickening of glomerular basement membrane due to immune complexes deposition and cell proliferation caused by mesangial cell and influx of inflammatory cells, mainly monocytes. Identification of circulating antibodies against some complement substrates supports the autoimmune pathogenesis of this disease. MPGN accounts for 4–5% of all glomerular diseases. The outcome is usually poor; the estimated renal survival ranges from 60 to 65% after 10–15 years from the initial renal biopsy, regardless of treatment. Signs of prognostic value are: nephrotic syndrome, renal impairment, high blood pressure, crescents and tubulointerstitial involvement in biopsy. Corticosteroids are the only treatment that has shown prognostic improvement of this disease in children, not in adults. More... »

PAGES

503-506

Book

TITLE

Diagnostic Criteria in Autoimmune Diseases

ISBN

978-1-60327-427-2
978-1-60327-285-8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-60327-285-8_92

DOI

http://dx.doi.org/10.1007/978-1-60327-285-8_92

DIMENSIONS

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