Use of Zebrafish to Dissect Gene Programs Regulating Hematopoietic Stem Cells View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2009

AUTHORS

Colleen E. Albacker , Leonard I. Zon

ABSTRACT

Hematopoietic stem cells (HSCs) are responsible for creating each cellular component of the vertebrate blood system. However, HSCs must also self-renew to maintain their own population so that the blood system always has the capacity to be reconstituted. This balance of HSCs producing more HSCs as well as differentiated blood cells is regulated by several extrinsic pathways. The Cdx/Hox pathway has been shown to have a role in regulating embryonic stem cells, with the zebrafish caudal genes cdx4 and cdx1a acting upstream of the Hox clusters to aid in the formation of blood. The Notch pathway has been shown in mice and zebrafish to be a positive regulator of HSC self-renewal; experiments in fish revealed that this pathway signals through the HSC transcription factor runx1 to do so. Lastly, the action of prostaglandin E2 was found to positively regulate HSCs, and treatment with this compound leads to increased recovery kinetics of the hematopoietic system upon acute injury or transplantation. This knowledge is currently being applied in the clinic as a means to increase the success rates of umbilical cord blood transplantations in adult patients. More... »

PAGES

101-110

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-60327-227-8_9

DOI

http://dx.doi.org/10.1007/978-1-60327-227-8_9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017338701


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